lisinopril-7403 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the lisinopril-7403 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD6 abhydrolase domain containing 6
ADRBK1 adrenergic, beta, receptor kinase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOE apolipoprotein E
AR androgen receptor
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC88C coiled-coil domain containing 88C
CFLAR CASP8 and FADD-like apoptosis regulator
CHKB choline kinase beta
CLCN2 chloride channel, voltage-sensitive 2
CLTA clathrin, light chain A
COL5A1 collagen, type V, alpha 1
CSPP1 centrosome and spindle pole associated protein 1
DOCK9 dedicator of cytokinesis 9
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EED embryonic ectoderm development
F8 coagulation factor VIII, procoagulant component
FAM149B1 family with sequence similarity 149, member B1
FAM188A family with sequence similarity 188, member A
FAM65A family with sequence similarity 65, member A
FBXL5 F-box and leucine-rich repeat protein 5
FCMR Fc fragment of IgM receptor
FGFR1 fibroblast growth factor receptor 1
FOXN3 forkhead box N3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GFER growth factor, augmenter of liver regeneration
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR137 G protein-coupled receptor 137
HPS4 Hermansky-Pudlak syndrome 4
IGHA1 immunoglobulin heavy constant alpha 1
IL4R interleukin 4 receptor
INSR insulin receptor
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KDM5A lysine (K)-specific demethylase 5A
KDM8 lysine (K)-specific demethylase 8
KLHL26 kelch-like family member 26
KRT19P2 keratin 19 pseudogene 2
LPCAT3 lysophosphatidylcholine acyltransferase 3
MPPE1 metallophosphoesterase 1
MPZL1 myelin protein zero-like 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MZF1 myeloid zinc finger 1
NDE1 nudE neurodevelopment protein 1
NDRG2 NDRG family member 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NOS1 nitric oxide synthase 1 (neuronal)
NUMA1 nuclear mitotic apparatus protein 1
OAZ2 ornithine decarboxylase antizyme 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PAPPA2 pappalysin 2
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCD1 phospholipase C, delta 1
PLSCR3 phospholipid scramblase 3
POM121 POM121 transmembrane nucleoporin
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRMT2 protein arginine methyltransferase 2
PROS1 protein S (alpha)
PSD3 pleckstrin and Sec7 domain containing 3
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RANBP17 RAN binding protein 17
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBKS ribokinase
RPAIN RPA interacting protein
RPH3A rabphilin 3A
RTEL1 regulator of telomere elongation helicase 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
SYNGR1 synaptogyrin 1
TLR5 toll-like receptor 5
TMPRSS2 transmembrane protease, serine 2
TTC9 tetratricopeptide repeat domain 9
TUBA4B tubulin, alpha 4b
UBE3B ubiquitin protein ligase E3B
UPP1 uridine phosphorylase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VLDLR very low density lipoprotein receptor
WDR62 WD repeat domain 62
WSCD1 WSC domain containing 1
XDH xanthine dehydrogenase
XK X-linked Kx blood group
YY2 YY2 transcription factor
ZNF212 zinc finger protein 212
ZNF506 zinc finger protein 506
ZNF609 zinc finger protein 609
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACVR2B activin A receptor, type IIB
ACYP2 acylphosphatase 2, muscle type
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGAP11A Rho GTPase activating protein 11A
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARL15 ADP-ribosylation factor-like 15
ATAD5 ATPase family, AAA domain containing 5
AUH AU RNA binding protein/enoyl-CoA hydratase
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF132 chromosome 14 open reading frame 132
C17ORF70 chromosome 17 open reading frame 70
CAMTA1 calmodulin binding transcription activator 1
CAPN15 calpain 15
CASD1 CAS1 domain containing 1
CLSPN claspin
CPTP ceramide-1-phosphate transfer protein
DDIT3 DNA-damage-inducible transcript 3
DGKD diacylglycerol kinase, delta 130kDa
ECSIT ECSIT signalling integrator
EVPL envoplakin
FAM86C1 family with sequence similarity 86, member C1
FBXL15 F-box and leucine-rich repeat protein 15
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLI3 GLI family zinc finger 3
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPHN gephyrin
GRAMD3 GRAM domain containing 3
HIRA histone cell cycle regulator
HP1BP3 heterochromatin protein 1, binding protein 3
IL17RA interleukin 17 receptor A
INSIG2 insulin induced gene 2
IRAK4 interleukin-1 receptor-associated kinase 4
KCNK15 potassium channel, two pore domain subfamily K, member 15
KIAA0895 KIAA0895
KRT13 keratin 13, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00115 long intergenic non-protein coding RNA 115
LOC100272216 uncharacterized LOC100272216
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC49 leucine rich repeat containing 49
LRRC8E leucine rich repeat containing 8 family, member E
MAP1S microtubule-associated protein 1S
MFSD12 major facilitator superfamily domain containing 12
MMP9 matrix metallopeptidase 9
NR2C2 nuclear receptor subfamily 2, group C, member 2
OGFRL1 opioid growth factor receptor-like 1
PCDHB3 protocadherin beta 3
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QTRT1 queuine tRNA-ribosyltransferase 1
RGS19 regulator of G-protein signaling 19
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF141 ring finger protein 141
RNF25 ring finger protein 25
SH2D4A SH2 domain containing 4A
SIK1 salt-inducible kinase 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNIP1 Smad nuclear interacting protein 1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNUPN snurportin 1
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPIDR scaffolding protein involved in DNA repair
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TCTN2 tectonic family member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPST1 tyrosylprotein sulfotransferase 1
TRAF2 TNF receptor-associated factor 2
TRAF5 TNF receptor-associated factor 5
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USP36 ubiquitin specific peptidase 36
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASP vasodilator-stimulated phosphoprotein
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR76 WD repeat domain 76
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZMAT5 zinc finger, matrin-type 5
ZNF189 zinc finger protein 189
ZSCAN9 zinc finger and SCAN domain containing 9