lincomycin-2380 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the lincomycin-2380 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADARB1 adenosine deaminase, RNA-specific, B1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGAP35 Rho GTPase activating protein 35
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB2 arrestin, beta 2
ATP10A ATPase, class V, type 10A
C19ORF66 chromosome 19 open reading frame 66
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC106 coiled-coil domain containing 106
CCSER2 coiled-coil serine-rich protein 2
CDH8 cadherin 8, type 2
CIB2 calcium and integrin binding family member 2
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRMP1 collapsin response mediator protein 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CUL4B cullin 4B
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DFNA5 deafness, autosomal dominant 5
E2F4 E2F transcription factor 4, p107/p130-binding
EEA1 early endosome antigen 1
EPX eosinophil peroxidase
FAM63B family with sequence similarity 63, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FOXC1 forkhead box C1
FST follistatin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GOSR2 golgi SNAP receptor complex member 2
HHLA3 HERV-H LTR-associating 3
HIPK3 homeodomain interacting protein kinase 3
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HNF1B HNF1 homeobox B
HPCAL4 hippocalcin like 4
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
ICK intestinal cell (MAK-like) kinase
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IGLJ3 immunoglobulin lambda joining 3
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPP5K inositol polyphosphate-5-phosphatase K
KHK ketohexokinase (fructokinase)
MAP2K5 mitogen-activated protein kinase kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKL2 MKL/myocardin-like 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MRPS18C mitochondrial ribosomal protein S18C
MTMR8 myotubularin related protein 8
MYLK myosin light chain kinase
MYO1B myosin IB
NAP1L2 nucleosome assembly protein 1-like 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NMT2 N-myristoyltransferase 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH4 notch 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCG1 phospholipase C, gamma 1
PRDM12 PR domain containing 12
PROCR protein C receptor, endothelial
PRR14L proline rich 14-like
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RANBP3 RAN binding protein 3
RB1 retinoblastoma 1
RBM26 RNA binding motif protein 26
RBM34 RNA binding motif protein 34
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RECQL5 RecQ protein-like 5
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
RWDD3 RWD domain containing 3
SAFB scaffold attachment factor B
SCAMP5 secretory carrier membrane protein 5
SELPLG selectin P ligand
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35G2 solute carrier family 35, member G2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRR1A small proline-rich protein 1A
SUGP1 SURP and G patch domain containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMP2 TIMP metallopeptidase inhibitor 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
USP2 ubiquitin specific peptidase 2
VWA1 von Willebrand factor A domain containing 1
ZNF609 zinc finger protein 609
ZNF668 zinc finger protein 668

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACP6 acid phosphatase 6, lysophosphatidic
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD40 ankyrin repeat domain 40
ARMC6 armadillo repeat containing 6
ASB13 ankyrin repeat and SOCS box containing 13
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAHD1 bromo adjacent homology domain containing 1
BCORL1 BCL6 corepressor-like 1
BHLHE41 basic helix-loop-helix family, member e41
C1ORF95 chromosome 1 open reading frame 95
C22ORF46 chromosome 22 open reading frame 46
C3 complement component 3
C5AR1 complement component 5a receptor 1
CAPN5 calpain 5
CASZ1 castor zinc finger 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDA cytidine deaminase
CDK20 cyclin-dependent kinase 20
CECR1 cat eye syndrome chromosome region, candidate 1
CISH cytokine inducible SH2-containing protein
CPNE7 copine VII
CPTP ceramide-1-phosphate transfer protein
CRY2 cryptochrome circadian clock 2
CTAGE9 CTAGE family, member 9
DDN dendrin
DGAT1 diacylglycerol O-acyltransferase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOC2A double C2-like domains, alpha
DOK3 docking protein 3
EMILIN2 elastin microfibril interfacer 2
ERCC4 excision repair cross-complementation group 4
F5 coagulation factor V (proaccelerin, labile factor)
FAM50B family with sequence similarity 50, member B
FBXL15 F-box and leucine-rich repeat protein 15
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCHO1 FCH domain only 1
FHOD1 formin homology 2 domain containing 1
GEMIN8 gem (nuclear organelle) associated protein 8
GLCE glucuronic acid epimerase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR27 G protein-coupled receptor 27
GPR65 G protein-coupled receptor 65
GRIP2 glutamate receptor interacting protein 2
HAMP hepcidin antimicrobial peptide
HIST1H2AJ histone cluster 1, H2aj
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCTD20 potassium channel tetramerization domain containing 20
KLK15 kallikrein-related peptidase 15
KLK5 kallikrein-related peptidase 5
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAX1 lymphocyte transmembrane adaptor 1
LIG4 ligase IV, DNA, ATP-dependent
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP5 low density lipoprotein receptor-related protein 5
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTMR12 myotubularin related protein 12
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
NOD1 nucleotide-binding oligomerization domain containing 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
POLM polymerase (DNA directed), mu
POM121 POM121 transmembrane nucleoporin
POR P450 (cytochrome) oxidoreductase
PQLC2 PQ loop repeat containing 2
PTCD2 pentatricopeptide repeat domain 2
PYCRL pyrroline-5-carboxylate reductase-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RPAP2 RNA polymerase II associated protein 2
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SNRPN small nuclear ribonucleoprotein polypeptide N
SOX12 SRY (sex determining region Y)-box 12
TBC1D2 TBC1 domain family, member 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TKFC triokinase/FMN cyclase
TMC7 transmembrane channel-like 7
TMEM254 transmembrane protein 254
TMEM53 transmembrane protein 53
TRAIP TRAF interacting protein
TSPAN32 tetraspanin 32
TXLNG taxilin gamma
UCN urocortin
USB1 U6 snRNA biogenesis 1
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VNN2 vanin 2
YIPF1 Yip1 domain family, member 1
ZFP37 ZFP37 zinc finger protein
ZNF276 zinc finger protein 276
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862