ligase Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

307 proteins co-occuring with the biological term ligase in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC1 anaphase promoting complex subunit 1
APLF aprataxin and PNKP like factor
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARRB1 arrestin, beta 1
ATF4 activating transcription factor 4
ATG13 autophagy related 13
ATM ATM serine/threonine kinase
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BCAR1 breast cancer anti-estrogen resistance 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARD9 caspase recruitment domain family, member 9
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCDC50 coiled-coil domain containing 50
CCDC6 coiled-coil domain containing 6
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC34 cell division cycle 34
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLCN2 chloride channel, voltage-sensitive 2
CREBBP CREB binding protein
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRTC2 CREB regulated transcription coactivator 2
CRYAB crystallin, alpha B
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUL3 cullin 3
CUL5 cullin 5
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAXX death-domain associated protein
DCLRE1C DNA cross-link repair 1C
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPTOR DEP domain containing MTOR-interacting protein
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
EP300 E1A binding protein p300
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ESRRG estrogen-related receptor gamma
EXOSC9 exosome component 9
FBXL2 F-box and leucine-rich repeat protein 2
FBXO4 F-box protein 4
FBXO43 F-box protein 43
FBXO5 F-box protein 5
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FGD1 FYVE, RhoGEF and PH domain containing 1
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRM5 glutamate receptor, metabotropic 5
GSK3B glycogen synthase kinase 3 beta
GTF2IRD1 GTF2I repeat domain containing 1
H2AFX H2A histone family, member X
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIST1H3A histone cluster 1, H3a
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1RL1 interleukin 1 receptor-like 1
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
ITCH itchy E3 ubiquitin protein ligase
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KATNA1 katanin p60 (ATPase containing) subunit A 1
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KMT2A lysine (K)-specific methyltransferase 2A
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAK male germ cell-associated kinase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MID1 midline 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOD1 myogenic differentiation 1
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NF2 neurofibromin 2 (merlin)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NGFR nerve growth factor receptor
NHEJ1 nonhomologous end-joining factor 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NRIP1 nuclear receptor interacting protein 1
OCLN occludin
ODF1 outer dense fiber of sperm tails 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PCGF1 polycomb group ring finger 1
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PELI1 pellino E3 ubiquitin protein ligase 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIAS1 protein inhibitor of activated STAT, 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINK1 PTEN induced putative kinase 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLCG1 phospholipase C, gamma 1
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTTG1 pituitary tumor-transforming 1
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG2 recombination activating gene 2
RANGAP1 Ran GTPase activating protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBL2 retinoblastoma-like 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RHOT1 ras homolog family member T1
RHOT2 ras homolog family member T2
RICTOR RPTOR independent companion of MTOR, complex 2
RIPK2 receptor-interacting serine-threonine kinase 2
RLIM ring finger protein, LIM domain interacting
RNF2 ring finger protein 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
RPA2 replication protein A2, 32kDa
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
SATB1 SATB homeobox 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SGK1 serum/glucocorticoid regulated kinase 1
SGK3 serum/glucocorticoid regulated kinase family, member 3
SH2B2 SH2B adaptor protein 2
SH3GL2 SH3-domain GRB2-like 2
SH3RF1 SH3 domain containing ring finger 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIK2 salt-inducible kinase 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SP1 Sp1 transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TELO2 telomere maintenance 2
TLN1 talin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TRIM21 tripartite motif containing 21
TRIM32 tripartite motif containing 32
TSC2 tuberous sclerosis 2
TTC3 tetratricopeptide repeat domain 3
TTI1 TELO2 interacting protein 1
TXN thioredoxin
UBA1 ubiquitin-like modifier activating enzyme 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
ULK1 unc-51 like autophagy activating kinase 1
USP10 ubiquitin specific peptidase 10
USP37 ubiquitin specific peptidase 37
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR77 WD repeat domain 77
WEE1 WEE1 G2 checkpoint kinase
WRN Werner syndrome, RecQ helicase-like
WWTR1 WW domain containing transcription regulator 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YAP1 Yes-associated protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3HC1 zinc finger, C3HC-type containing 1
ZFYVE28 zinc finger, FYVE domain containing 28