leydig cell hyperplasia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased number of interstitial cells of the seminiferous tubules that secrete testosterone (Mammalian Phenotype Ontology, MP_0001152)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001152
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Genes

36 gene mutations causing the leydig cell hyperplasia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AMH anti-Mullerian hormone
AMHR2 anti-Mullerian hormone receptor, type II
AR androgen receptor
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BCL2L2 BCL2-like 2
BMP8B bone morphogenetic protein 8b
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLCN2 chloride channel, voltage-sensitive 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DHH desert hedgehog
E2F6 E2F transcription factor 6
EGR4 early growth response 4
FANCA Fanconi anemia, complementation group A
FANCG Fanconi anemia, complementation group G
FANCM Fanconi anemia, complementation group M
ING2 inhibitor of growth family, member 2
KIF18A kinesin family member 18A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LHCGR luteinizing hormone/choriogonadotropin receptor
MAP7 microtubule-associated protein 7
MEN1 multiple endocrine neoplasia I
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PTDSS2 phosphatidylserine synthase 2
SAFB scaffold attachment factor B
SIX5 SIX homeobox 5
STAR steroidogenic acute regulatory protein
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
ZBTB16 zinc finger and BTB domain containing 16