levcycloserine-4346 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the levcycloserine-4346 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADL acyl-CoA dehydrogenase, long chain
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ADAM29 ADAM metallopeptidase domain 29
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADRA1A adrenoceptor alpha 1A
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATP11A ATPase, class VI, type 11A
BARX2 BARX homeobox 2
BCL2 B-cell CLL/lymphoma 2
BMP15 bone morphogenetic protein 15
BRDT bromodomain, testis-specific
BTBD7 BTB (POZ) domain containing 7
C11ORF1 chromosome 11 open reading frame 1
C11ORF30 chromosome 11 open reading frame 30
CCDC33 coiled-coil domain containing 33
CD200 CD200 molecule
CD47 CD47 molecule
CDH8 cadherin 8, type 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP41 centrosomal protein 41kDa
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL4A6 collagen, type IV, alpha 6
CTNS cystinosin, lysosomal cystine transporter
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAH7 dynein, axonemal, heavy chain 7
DOC2B double C2-like domains, beta
DOCK6 dedicator of cytokinesis 6
DUSP9 dual specificity phosphatase 9
EFS embryonal Fyn-associated substrate
EMC3 ER membrane protein complex subunit 3
FGF21 fibroblast growth factor 21
FLT3 fms-related tyrosine kinase 3
FRMD1 FERM domain containing 1
GAS7 growth arrest-specific 7
GFER growth factor, augmenter of liver regeneration
GPER1 G protein-coupled estrogen receptor 1
GPR135 G protein-coupled receptor 135
GRM2 glutamate receptor, metabotropic 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H2BB histone cluster 1, H2bb
ICOSLG inducible T-cell co-stimulator ligand
IL37 interleukin 37
JAM3 junctional adhesion molecule 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT4 keratin 4, type II
LIMK1 LIM domain kinase 1
LINC00216 long intergenic non-protein coding RNA 216
LMO1 LIM domain only 1 (rhombotin 1)
MAN1C1 mannosidase, alpha, class 1C, member 1
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MC5R melanocortin 5 receptor
MIIP migration and invasion inhibitory protein
MOBP myelin-associated oligodendrocyte basic protein
MXD4 MAX dimerization protein 4
NKX2-5 NK2 homeobox 5
PCDHGA8 protocadherin gamma subfamily A, 8
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PGLYRP4 peptidoglycan recognition protein 4
PLAC4 placenta-specific 4
PLK3 polo-like kinase 3
PLSCR4 phospholipid scramblase 4
PRODH2 proline dehydrogenase (oxidase) 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRB protein tyrosine phosphatase, receptor type, B
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELN reelin
SHOX2 short stature homeobox 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC30A10 solute carrier family 30, member 10
SLC35G2 solute carrier family 35, member G2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSX3 synovial sarcoma, X breakpoint 3
STAB2 stabilin 2
STOM stomatin
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNE1 spectrin repeat containing, nuclear envelope 1
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TBKBP1 TBK1 binding protein 1
TBL1Y transducin (beta)-like 1, Y-linked
TBX3 T-box 3
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDRD12 tudor domain containing 12
TEX13B testis expressed 13B
TGFBR1 transforming growth factor, beta receptor 1
TNS1 tensin 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
YPEL1 yippee-like 1 (Drosophila)
ZC3H13 zinc finger CCCH-type containing 13
ZNF235 zinc finger protein 235
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ANXA2P3 annexin A2 pseudogene 3
ARPIN actin-related protein 2/3 complex inhibitor
ARRB1 arrestin, beta 1
BCORL1 BCL6 corepressor-like 1
C14ORF79 chromosome 14 open reading frame 79
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNO cyclin O
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH18 cadherin 18, type 2
CGA glycoprotein hormones, alpha polypeptide
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLSTN2 calsyntenin 2
CRIP1 cysteine-rich protein 1 (intestinal)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DIXDC1 DIX domain containing 1
DNASE1L2 deoxyribonuclease I-like 2
DOCK1 dedicator of cytokinesis 1
DPY19L1P1 DPY19L1 pseudogene 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL7 EGF-like-domain, multiple 7
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHX2 epoxide hydrolase 2, cytoplasmic
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBRS fibrosin
FBXO2 F-box protein 2
FER fer (fps/fes related) tyrosine kinase
FHOD1 formin homology 2 domain containing 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKRP fukutin related protein
FLJ11710 uncharacterized protein FLJ11710
FSTL1 follistatin-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS2 growth arrest-specific 2
GFI1 growth factor independent 1 transcription repressor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH3 G patch domain containing 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GREB1L growth regulation by estrogen in breast cancer-like
HDAC7 histone deacetylase 7
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H3B histone cluster 1, H3b
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC4 homeobox C4
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0319L KIAA0319-like
KLHL26 kelch-like family member 26
LONRF3 LON peptidase N-terminal domain and ring finger 3
LYRM9 LYR motif containing 9
MBTD1 mbt domain containing 1
MFAP2 microfibrillar-associated protein 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NPTX1 neuronal pentraxin I
OLFML2A olfactomedin-like 2A
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PICK1 protein interacting with PRKCA 1
PLAC1 placenta-specific 1
RAB40C RAB40C, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RUFY2 RUN and FYVE domain containing 2
S100A7 S100 calcium binding protein A7
SAYSD1 SAYSVFN motif domain containing 1
SLPI secretory leukocyte peptidase inhibitor
SND1-IT1 SND1 intronic transcript 1
SOAT2 sterol O-acyltransferase 2
STRA6 stimulated by retinoic acid 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCP10 t-complex 10
TDRD1 tudor domain containing 1
TH tyrosine hydroxylase
TPSG1 tryptase gamma 1
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA4B tubulin, alpha 4b
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
ZBTB6 zinc finger and BTB domain containing 6
ZFHX4 zinc finger homeobox 4
ZNF286A zinc finger protein 286A
ZNF446 zinc finger protein 446
ZNF532 zinc finger protein 532
ZNF551 zinc finger protein 551