leukocyte differentiation Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. (Gene Ontology, GO_0002521)
External Link http://amigo.geneontology.org/amigo/term/GO:0002521
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Genes

250 genes participating in the leukocyte differentiation biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
AICDA activation-induced cytidine deaminase
ANXA1 annexin A1
APC adenomatous polyposis coli
ATP11C ATPase, class VI, type 11C
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AXL AXL receptor tyrosine kinase
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
BATF basic leucine zipper transcription factor, ATF-like
BATF2 basic leucine zipper transcription factor, ATF-like 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BLK BLK proto-oncogene, Src family tyrosine kinase
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBFB core-binding factor, beta subunit
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD86 CD86 molecule
CD8A CD8a molecule
CDC42 cell division cycle 42
CDK6 cyclin-dependent kinase 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHD7 chromodomain helicase DNA binding protein 7
CHUK conserved helix-loop-helix ubiquitous kinase
CLCF1 cardiotrophin-like cytokine factor 1
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCLRE1C DNA cross-link repair 1C
DCSTAMP dendrocyte expressed seven transmembrane protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFNA2 ephrin-A2
EFNA4 ephrin-A4
EGR1 early growth response 1
EOMES eomesodermin
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADD Fas (TNFRSF6)-associated via death domain
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FOXP1 forkhead box P1
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GAB2 GRB2-associated binding protein 2
GAB3 GRB2-associated binding protein 3
GAS6 growth arrest-specific 6
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA3 GATA binding protein 3
GIMAP1 GTPase, IMAP family member 1
GLI3 GLI family zinc finger 3
GLO1 glyoxalase I
GPC3 glypican 3
GPR183 G protein-coupled receptor 183
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HHEX hematopoietically expressed homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNK interferon, kappa
IFNW1 interferon, omega 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL11 interleukin 11
IL12B interleukin 12B
IL15 interleukin 15
IL17C interleukin 17C
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IL25 interleukin 25
IL31RA interleukin 31 receptor A
IL4 interleukin 4
IL7R interleukin 7 receptor
IREB2 iron-responsive element binding protein 2
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITK IL2-inducible T-cell kinase
JAG2 jagged 2
JAGN1 jagunal homolog 1 (Drosophila)
JAK3 Janus kinase 3
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIG4 ligase IV, DNA, ATP-dependent
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LRRC8A leucine rich repeat containing 8 family, member A
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MAPK14 mitogen-activated protein kinase 14
MED1 mediator complex subunit 1
MEF2C myocyte enhancer factor 2C
MERTK MER proto-oncogene, tyrosine kinase
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MSH2 mutS homolog 2
MT1G metallothionein 1G
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NCOR1 nuclear receptor corepressor 1
NFAM1 NFAT activating protein with ITAM motif 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NHEJ1 nonhomologous end-joining factor 1
NKAP NFKB activating protein
NKX2-3 NK2 homeobox 3
NOTCH2 notch 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OCSTAMP osteoclast stimulatory transmembrane protein
ONECUT1 one cut homeobox 1
OSTM1 osteopetrosis associated transmembrane protein 1
PARP1 poly (ADP-ribose) polymerase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PDE1B phosphodiesterase 1B, calmodulin-dependent
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PKNOX1 PBX/knotted 1 homeobox 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POLM polymerase (DNA directed), mu
POU1F1 POU class 1 homeobox 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRTN3 proteinase 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RIPK3 receptor-interacting serine-threonine kinase 3
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPS6 ribosomal protein S6
RRAS related RAS viral (r-ras) oncogene homolog
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX2 runt-related transcription factor 2
SATB1 SATB homeobox 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SHH sonic hedgehog
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TAL1 T-cell acute lymphocytic leukemia 1
TBX21 T-box 21
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THOC5 THO complex 5
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TP53 tumor protein p53
TPD52 tumor protein D52
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TUSC2 tumor suppressor candidate 2
TXK TXK tyrosine kinase
TYRO3 TYRO3 protein tyrosine kinase
UBD ubiquitin D
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPRBP Vpr (HIV-1) binding protein
WNT1 wingless-type MMTV integration site family, member 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM1 zinc finger protein, FOG family member 1
ZNF683 zinc finger protein 683