leukemia Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.|A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)|A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. (Experimental Factor Ontology, EFO_0000565)
Similar Terms
Downloads & Tools

Genes

181 proteins co-occuring with the biological term leukemia in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACIN1 apoptotic chromatin condensation inducer 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
ANXA2 annexin A2
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATXN1 ataxin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BID BH3 interacting domain death agonist
BLM Bloom syndrome, RecQ helicase-like
BTK Bruton agammaglobulinemia tyrosine kinase
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD28 CD28 molecule
CD300A CD300a molecule
CD300LF CD300 molecule-like family member f
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF6 eukaryotic translation initiation factor 6
EP300 E1A binding protein p300
EPHB6 EPH receptor B6
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
EZR ezrin
FANCG Fanconi anemia, complementation group G
FBXO5 F-box protein 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FES FES proto-oncogene, tyrosine kinase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3 fms-related tyrosine kinase 3
FOXL2 forkhead box L2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GSK3B glycogen synthase kinase 3 beta
GUK1 guanylate kinase 1
H2AFX H2A histone family, member X
HIST1H2BB histone cluster 1, H2bb
HIST1H3A histone cluster 1, H3a
HMGA1 high mobility group AT-hook 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA9 homeobox A9
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RA interleukin 2 receptor, alpha
IL6ST interleukin 6 signal transducer
INPPL1 inositol polyphosphate phosphatase-like 1
IRF8 interferon regulatory factor 8
JAK2 Janus kinase 2
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KMT2A lysine (K)-specific methyltransferase 2A
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIFR leukemia inhibitory factor receptor alpha
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LMNB1 lamin B1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MED28 mediator complex subunit 28
MET MET proto-oncogene, receptor tyrosine kinase
MITF microphthalmia-associated transcription factor
MKL1 megakaryoblastic leukemia (translocation) 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL12B myosin, light chain 12B, regulatory
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSMR oncostatin M receptor
PCBP2 poly(rC) binding protein 2
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PGM1 phosphoglucomutase 1
PHF8 PHD finger protein 8
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCG1 phospholipase C, gamma 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PXN paxillin
RAD51 RAD51 recombinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RMDN3 regulator of microtubule dynamics 3
RPA2 replication protein A2, 32kDa
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
SATB1 SATB homeobox 1
SET SET nuclear proto-oncogene
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP2 SH3-domain binding protein 2
SNAP23 synaptosomal-associated protein, 23kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF10 serine/arginine-rich splicing factor 10
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STMN1 stathmin 1
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TAL2 T-cell acute lymphocytic leukemia 2
THOC5 THO complex 5
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
VAV1 vav 1 guanine nucleotide exchange factor
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YAP1 Yes-associated protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB16 zinc finger and BTB domain containing 16