leukaemia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.|A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)|A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. (Experimental Factor Ontology, EFO_0000565)
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Genes

191 genes co-occuring with the biological term leukaemia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGO2 argonaute RISC catalytic component 2
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX12 arachidonate 12-lipoxygenase
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP8 aquaporin 8
ARL11 ADP-ribosylation factor-like 11
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC8 baculoviral IAP repeat containing 8
BLNK B-cell linker
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
BST2 bone marrow stromal cell antigen 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD180 CD180 molecule
CD38 CD38 molecule
CD70 CD70 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CKAP2 cytoskeleton associated protein 2
CNR2 cannabinoid receptor 2 (macrophage)
COL18A1 collagen, type XVIII, alpha 1
CREBBP CREB binding protein
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DEFA4 defensin, alpha 4, corticostatin
DEFT1P defensin, theta 1 pseudogene
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
EIF4E eukaryotic translation initiation factor 4E
ELANE elastase, neutrophil expressed
ENG endoglin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOXO1 forkhead box O1
FTO fat mass and obesity associated
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HEMGN hemogen
HIC1 hypermethylated in cancer 1
HLA-A major histocompatibility complex, class I, A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGH immunoglobulin heavy locus
IGK immunoglobulin kappa locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF4 interferon regulatory factor 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDM5A lysine (K)-specific demethylase 5A
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
KRAS Kirsten rat sarcoma viral oncogene homolog
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LMO2 LIM domain only 2 (rhombotin-like 1)
MADD MAP-kinase activating death domain
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MIR181A1 microRNA 181a-1
MIR181A2 microRNA 181a-2
MIR221 microRNA 221
MIR222 microRNA 222
MIR335 microRNA 335
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NF2 neurofibromin 2 (merlin)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PADI2 peptidyl arginine deiminase, type II
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGF placental growth factor
PGR progesterone receptor
PML promyelocytic leukemia
PRAME preferentially expressed antigen in melanoma
PRDM12 PR domain containing 12
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRL prolactin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD51 RAD51 recombinase
RHOA ras homolog family member A
RHOU ras homolog family member U
ROR1 receptor tyrosine kinase-like orphan receptor 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELL selectin L
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPT6 septin 6
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC19A1 solute carrier family 19 (folate transporter), member 1
SPI1 Spi-1 proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TERC telomerase RNA component
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TRIB2 tribbles pseudokinase 2
TRIP12 thyroid hormone receptor interactor 12
TTR transthyretin
ULBP2 UL16 binding protein 2
USF2 upstream transcription factor 2, c-fos interacting
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa