letrozole-4824 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the letrozole-4824 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
AHI1 Abelson helper integration site 1
AMPD1 adenosine monophosphate deaminase 1
ARF1 ADP-ribosylation factor 1
ARNT aryl hydrocarbon receptor nuclear translocator
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BMP5 bone morphogenetic protein 5
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CALU calumenin
CAPN7 calpain 7
CAPRIN1 cell cycle associated protein 1
CCNE2 cyclin E2
CDK2 cyclin-dependent kinase 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COMMD10 COMM domain containing 10
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGCR2 DiGeorge syndrome critical region gene 2
DPY19L1P1 DPY19L1 pseudogene 1
DTNA dystrobrevin, alpha
ELK1 ELK1, member of ETS oncogene family
ENO1 enolase 1, (alpha)
FAS Fas cell surface death receptor
FH fumarate hydratase
FKBP1A FK506 binding protein 1A, 12kDa
GDI2 GDP dissociation inhibitor 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXA4 homeobox A4
HSF1 heat shock transcription factor 1
HSPA4 heat shock 70kDa protein 4
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFT27 intraflagellar transport 27
IL17RC interleukin 17 receptor C
ITGA6 integrin, alpha 6
KCTD20 potassium channel tetramerization domain containing 20
KLF3 Kruppel-like factor 3 (basic)
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MST1 macrophage stimulating 1
MTUS1 microtubule associated tumor suppressor 1
NADK NAD kinase
NLE1 notchless homolog 1 (Drosophila)
NOTCH2 notch 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUMA1 nuclear mitotic apparatus protein 1
NXT2 nuclear transport factor 2-like export factor 2
OCRL oculocerebrorenal syndrome of Lowe
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNX pecanex homolog (Drosophila)
PICALM phosphatidylinositol binding clathrin assembly protein
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
POT1 protection of telomeres 1
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRPF4B pre-mRNA processing factor 4B
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB35 RAB35, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RNF122 ring finger protein 122
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAMP1 secretory carrier membrane protein 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC23A Sec23 homolog A (S. cerevisiae)
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOS2 son of sevenless homolog 2 (Drosophila)
SPAG9 sperm associated antigen 9
SQLE squalene epoxidase
SRSF1 serine/arginine-rich splicing factor 1
SSBP2 single-stranded DNA binding protein 2
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D5 TBC1 domain family, member 5
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFDP1 transcription factor Dp-1
TM2D1 TM2 domain containing 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX4 TOX high mobility group box family member 4
TTC38 tetratricopeptide repeat domain 38
TUBGCP5 tubulin, gamma complex associated protein 5
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VAMP3 vesicle-associated membrane protein 3
WDR1 WD repeat domain 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNK1 WNK lysine deficient protein kinase 1
WWOX WW domain containing oxidoreductase
YIPF4 Yip1 domain family, member 4
ZMYND11 zinc finger, MYND-type containing 11
ZNF589 zinc finger protein 589
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACPP acid phosphatase, prostate
AFAP1 actin filament associated protein 1
ALPK1 alpha-kinase 1
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CDON cell adhesion associated, oncogene regulated
CEP97 centrosomal protein 97kDa
CNR2 cannabinoid receptor 2 (macrophage)
CORT cortistatin
CPED1 cadherin-like and PC-esterase domain containing 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EDAR ectodysplasin A receptor
EMID1 EMI domain containing 1
ENO2 enolase 2 (gamma, neuronal)
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FAM131A family with sequence similarity 131, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO46 F-box protein 46
FLCN folliculin
FLJ21369 uncharacterized protein FLJ21369
FLJ22184
GRPR gastrin-releasing peptide receptor
GRTP1 growth hormone regulated TBC protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIST1H4D histone cluster 1, H4d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
IDI2-AS1 IDI2 antisense RNA 1
INO80D INO80 complex subunit D
JMJD4 jumonji domain containing 4
KCTD17 potassium channel tetramerization domain containing 17
KIF13A kinesin family member 13A
KLF13 Kruppel-like factor 13
KLHL29 kelch-like family member 29
LAX1 lymphocyte transmembrane adaptor 1
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
LTBP2 latent transforming growth factor beta binding protein 2
LTC4S leukotriene C4 synthase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBTD1 mbt domain containing 1
MFGE8 milk fat globule-EGF factor 8 protein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MTSS1L metastasis suppressor 1-like
MUC3B mucin 3B, cell surface associated
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RIN2 Ras and Rab interactor 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RNF43 ring finger protein 43
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP2 RNA polymerase II associated protein 2
RPL10L ribosomal protein L10-like
SCGB2A2 secretoglobin, family 2A, member 2
SCHIP1 schwannomin interacting protein 1
SCN1B sodium channel, voltage gated, type I beta subunit
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A2 solute carrier family 17, member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPIDR scaffolding protein involved in DNA repair
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCP10 t-complex 10
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TLR5 toll-like receptor 5
TMEM212 transmembrane protein 212
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS2 tensin 2
TPCN1 two pore segment channel 1
UBTD1 ubiquitin domain containing 1
UPK2 uroplakin 2
USB1 U6 snRNA biogenesis 1
ZC3H3 zinc finger CCCH-type containing 3
ZNF134 zinc finger protein 134
ZNF365 zinc finger protein 365
ZNF580 zinc finger protein 580
ZNF721 zinc finger protein 721
ZNF747 zinc finger protein 747