lens epithelium Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Cuboidal epithelium covering the lens. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001873)
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Genes

379 proteins co-occuring with the tissue lens epithelium in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
CRYAA crystallin, alpha A 2.63412
CRYGS crystallin, gamma S 2.2794
CRYAB crystallin, alpha B 2.04926
MIP major intrinsic protein of lens fiber 1.92267
PSIP1 PC4 and SFRS1 interacting protein 1 1.89461
CRYBB1 crystallin, beta B1 1.87805
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.87185
ELANE elastase, neutrophil expressed 1.85791
FOXE3 forkhead box E3 1.71539
GJA8 gap junction protein, alpha 8, 50kDa 1.66007
FGF1 fibroblast growth factor 1 (acidic) 1.50528
GJA1 gap junction protein, alpha 1, 43kDa 1.50103
TGFB1 transforming growth factor, beta 1 1.46542
GJA3 gap junction protein, alpha 3, 46kDa 1.44218
TGFB2 transforming growth factor, beta 2 1.43524
BFSP2 beaded filament structural protein 2, phakinin 1.41353
FYCO1 FYVE and coiled-coil domain containing 1 1.40846
CRYBB2 crystallin, beta B2 1.39192
FN1 fibronectin 1 1.38322
FGF2 fibroblast growth factor 2 (basic) 1.3686
MSRB1 methionine sulfoxide reductase B1 1.28861
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.27157
PAX6 paired box 6 1.2671
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.12615
DNAH8 dynein, axonemal, heavy chain 8 1.11995
PRDX6 peroxiredoxin 6 1.09429
GLRX2 glutaredoxin 2 1.09164
PCNA proliferating cell nuclear antigen 1.09076
CRYBA2 crystallin, beta A2 1.07309
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.06294
CDC34 cell division cycle 34 1.03478
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.02513
LENEP lens epithelial protein 1.01549
BAX BCL2-associated X protein 1.01025
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.00763
SMAD2 SMAD family member 2 1.0037
PROX1 prospero homeobox 1 0.984991
TMEM114 transmembrane protein 114 0.978917
DNTT DNA nucleotidylexotransferase 0.961175
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.946087
GSR glutathione reductase 0.943505
CRYGD crystallin, gamma D 0.933624
IGF1 insulin-like growth factor 1 (somatomedin C) 0.932337
LAMA3 laminin, alpha 3 0.928906
USP35 ubiquitin specific peptidase 35 0.906256
CAT catalase 0.904978
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.887133
HSF4 heat shock transcription factor 4 0.8601
FGFR1 fibroblast growth factor receptor 1 0.857995
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.846225
UBE2A ubiquitin-conjugating enzyme E2A 0.836156
ANXA5 annexin A5 0.826942
LTBP1 latent transforming growth factor beta binding protein 1 0.823175
SMAD4 SMAD family member 4 0.81565
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.794792
SOX1 SRY (sex determining region Y)-box 1 0.793959
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.787716
JUN jun proto-oncogene 0.777325
SRP68 signal recognition particle 68kDa 0.774834
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.774419
GPX1 glutathione peroxidase 1 0.768197
DNASE2B deoxyribonuclease II beta 0.767783
MLEC malectin 0.749579
SLC16A12 solute carrier family 16, member 12 0.726507
ADAM9 ADAM metallopeptidase domain 9 0.726097
FBN1 fibrillin 1 0.721577
INS insulin 0.71583
CRYBB3 crystallin, beta B3 0.706402
TJP1 tight junction protein 1 0.705993
SMAD3 SMAD family member 3 0.696172
SOD2 superoxide dismutase 2, mitochondrial 0.685143
MMP2 matrix metallopeptidase 2 0.680248
BFSP1 beaded filament structural protein 1, filensin 0.679433
ANO8 anoctamin 8 0.676172
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.669657
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.66925
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.659897
UBE2B ubiquitin-conjugating enzyme E2B 0.655024
MSRA methionine sulfoxide reductase A 0.652589
GPX5 glutathione peroxidase 5 0.650966
TXN thioredoxin 0.648532
GPX4 glutathione peroxidase 4 0.647316
NXNL1 nucleoredoxin-like 1 0.646911
FTL ferritin, light polypeptide 0.642048
GPR137B G protein-coupled receptor 137B 0.637999
PEX7 peroxisomal biogenesis factor 7 0.634358
FTH1 ferritin, heavy polypeptide 1 0.633953
HSF2 heat shock transcription factor 2 0.629506
FOS FBJ murine osteosarcoma viral oncogene homolog 0.625465
CAV1 caveolin 1, caveolae protein, 22kDa 0.624658
KEAP1 kelch-like ECH-associated protein 1 0.621024
ILK integrin-linked kinase 0.617393
GJC1 gap junction protein, gamma 1, 45kDa 0.61699
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.616586
AKAP2 A kinase (PRKA) anchor protein 2 0.61578
PHRF1 PHD and ring finger domains 1 0.614571
BCL2 B-cell CLL/lymphoma 2 0.612958
CARD17 caspase recruitment domain family, member 17 0.60893
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.608527
PRDX3 peroxiredoxin 3 0.606112
TERT telomerase reverse transcriptase 0.600479
TBK1 TANK-binding kinase 1 0.597263
METTL3 methyltransferase like 3 0.593247
DMPK dystrophia myotonica-protein kinase 0.591641
CRYBA4 crystallin, beta A4 0.590839
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.586828
FAM46D family with sequence similarity 46, member D 0.578416
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.576015
AQP5 aquaporin 5 0.574816
LOXL1 lysyl oxidase-like 1 0.574416
TBATA thymus, brain and testes associated 0.572818
GLRX glutaredoxin (thioltransferase) 0.568823
CIB2 calcium and integrin binding family member 2 0.56603
TGFB3 transforming growth factor, beta 3 0.558457
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.55607
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.553286
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.55249
NID1 nidogen 1 0.551298
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.547724
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.546136
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.531879
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.531089
ATF4 activating transcription factor 4 0.529508
CETN3 centrin, EF-hand protein, 3 0.529113
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.522011
EPHA2 EPH receptor A2 0.517678
UBE2H ubiquitin-conjugating enzyme E2H 0.517678
TP53 tumor protein p53 0.516497
ATP11A ATPase, class VI, type 11A 0.51571
WNT8B wingless-type MMTV integration site family, member 8B 0.512957
CDK5 cyclin-dependent kinase 5 0.511778
TF transferrin 0.507457
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.506279
MSRB3 methionine sulfoxide reductase B3 0.502357
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.501965
PITX3 paired-like homeodomain 3 0.501182
CAPN10 calpain 10 0.497657
RPL21 ribosomal protein L21 0.494528
SPRY2 sprouty homolog 2 (Drosophila) 0.493745
TET1 tet methylcytosine dioxygenase 1 0.492963
CRYBA1 crystallin, beta A1 0.491791
CCDC80 coiled-coil domain containing 80 0.490619
FGFR2 fibroblast growth factor receptor 2 0.483596
LUM lumican 0.481259
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.479702
ANO3 anoctamin 3 0.479312
CTRL chymotrypsin-like 0.474646
SRP72 signal recognition particle 72kDa 0.474258
HSPA4 heat shock 70kDa protein 4 0.47348
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.472315
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.470375
EAF2 ELL associated factor 2 0.46766
MRPL13 mitochondrial ribosomal protein L13 0.462626
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.460305
LGSN lengsin, lens protein with glutamine synthetase domain 0.458759
TGM2 transglutaminase 2 0.457987
TXNRD1 thioredoxin reductase 1 0.452969
VCL vinculin 0.452584
SIX3 SIX homeobox 3 0.450657
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.445268
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.443347
ENO1 enolase 1, (alpha) 0.439507
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.437589
SHROOM3 shroom family member 3 0.432225
CTGF connective tissue growth factor 0.431077
SNPH syntaphilin 0.427636
CHKB choline kinase beta 0.426872
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.425344
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.425344
MAF1 MAF1 homolog (S. cerevisiae) 0.422673
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.414293
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.411251
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.41087
UBE2T ubiquitin-conjugating enzyme E2T 0.408972
MSRB2 methionine sulfoxide reductase B2 0.408592
MGST1 microsomal glutathione S-transferase 1 0.408592
AQP3 aquaporin 3 (Gill blood group) 0.408212
MMP9 matrix metallopeptidase 9 0.406315
CRYGC crystallin, gamma C 0.404797
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.40328
PROS1 protein S (alpha) 0.402523
SEBOX SEBOX homeobox 0.40025
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.399492
GLB1 galactosidase, beta 1 0.392309
TGFBR1 transforming growth factor, beta receptor 1 0.387027
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.383637
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.382884
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.380627
PARP1 poly (ADP-ribose) polymerase 1 0.380251
LIM2 lens intrinsic membrane protein 2, 19kDa 0.379123
AQP12A aquaporin 12A 0.37687
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.37687
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.376119
GSTA4 glutathione S-transferase alpha 4 0.370121
ERCC2 excision repair cross-complementation group 2 0.368624
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.367129
FGF4 fibroblast growth factor 4 0.361155
CAPN2 calpain 2, (m/II) large subunit 0.360036
ATG4B autophagy related 4B, cysteine peptidase 0.358174
ATF6 activating transcription factor 6 0.352598
MKL2 MKL/myocardin-like 2 0.352227
NCK2 NCK adaptor protein 2 0.351485
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.351114
PASK PAS domain containing serine/threonine kinase 0.348148
ITGB4 integrin, beta 4 0.347408
BCAR1 breast cancer anti-estrogen resistance 1 0.345928
FOXP2 forkhead box P2 0.345558
HK1 hexokinase 1 0.344818
AXL AXL receptor tyrosine kinase 0.340388
MIOX myo-inositol oxygenase 0.340388
CCNDBP1 cyclin D-type binding-protein 1 0.338545
MGST2 microsomal glutathione S-transferase 2 0.338177
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.33744
KDM5B lysine (K)-specific demethylase 5B 0.337072
TNC tenascin C 0.330827
FGFR3 fibroblast growth factor receptor 3 0.33046
AQP1 aquaporin 1 (Colton blood group) 0.330094
SDC2 syndecan 2 0.328628
NQO1 NAD(P)H dehydrogenase, quinone 1 0.324605
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.324239
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.322779
CCND1 cyclin D1 0.319498
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.317315
GSTA2 glutathione S-transferase alpha 2 0.317315
GSTA1 glutathione S-transferase alpha 1 0.31332
CD44 CD44 molecule (Indian blood group) 0.312957
ANO6 anoctamin 6 0.312232
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.312232
ADGRL3 adhesion G protein-coupled receptor L3 0.310059
TGM1 transglutaminase 1 0.310059
NKD1 naked cuticle homolog 1 (Drosophila) 0.308251
KLF6 Kruppel-like factor 6 0.307889
HSPB1 heat shock 27kDa protein 1 0.305722
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.305001
ASPH aspartate beta-hydroxylase 0.304279
ETNK1 ethanolamine kinase 1 0.302838
NRL neural retina leucine zipper 0.292793
STAT1 signal transducer and activator of transcription 1, 91kDa 0.291365
CELF2 CUGBP, Elav-like family member 2 0.290652
MUT methylmalonyl CoA mutase 0.289582
NUMA1 nuclear mitotic apparatus protein 1 0.289582
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.288514
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.286026
ATG3 autophagy related 3 0.280717
TEN1 TEN1 CST complex subunit 0.279659
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.278603
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.275444
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.275094
CUL1 cullin 1 0.274744
HIST1H2AJ histone cluster 1, H2aj 0.274045
HIST1H2AD histone cluster 1, H2ad 0.274045
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.274045
HIST1H2AH histone cluster 1, H2ah 0.273696
H2AFJ H2A histone family, member J 0.272997
SOX3 SRY (sex determining region Y)-box 3 0.272649
ACPP acid phosphatase, prostate 0.2723
H2AFY2 H2A histone family, member Y2 0.270909
HIST1H2AM histone cluster 1, H2am 0.269174
H2AFB2 H2A histone family, member B2 0.268828
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.268828
H2AFB1 H2A histone family, member B1 0.268828
H2AFV H2A histone family, member V 0.268482
IL1A interleukin 1, alpha 0.268137
HIST1H2AG histone cluster 1, H2ag 0.267791
CRYZ crystallin, zeta (quinone reductase) 0.267791
MIR26B microRNA 26b 0.267791
GADD45A growth arrest and DNA-damage-inducible, alpha 0.266757
BCAR3 breast cancer anti-estrogen resistance 3 0.266069
PYCR1 pyrroline-5-carboxylate reductase 1 0.264011
AQP10 aquaporin 10 0.264011
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.263669
FOXO4 forkhead box O4 0.263327
HIST1H2AB histone cluster 1, H2ab 0.262645
HIST1H2AE histone cluster 1, H2ae 0.262645
NOG noggin 0.261964
BNC1 basonuclin 1 0.261284
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.260606
GSTA3 glutathione S-transferase alpha 3 0.259591
STK39 serine threonine kinase 39 0.259254
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.258917
TGS1 trimethylguanosine synthase 1 0.256568
SFRP2 secreted frizzled-related protein 2 0.255234
KRT3 keratin 3, type II 0.25457
ITGB8 integrin, beta 8 0.252919
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.25259
POMP proteasome maturation protein 0.251934
WNT8A wingless-type MMTV integration site family, member 8A 0.249653
AQP11 aquaporin 11 0.249653
ITGB6 integrin, beta 6 0.249329
KLK15 kallikrein-related peptidase 15 0.249329
BCL2L1 BCL2-like 1 0.247399
CDC42 cell division cycle 42 0.247079
AGPS alkylglycerone phosphate synthase 0.246442
TXNIP thioredoxin interacting protein 0.246124
H2AFY H2A histone family, member Y 0.245491
FBN2 fibrillin 2 0.244545
SCRIB scribbled planar cell polarity protein 0.244232
NBN nibrin 0.243294
THBS1 thrombospondin 1 0.23961
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.239307
DNM2 dynamin 2 0.235167
IDO1 indoleamine 2,3-dioxygenase 1 0.235167
KRT8 keratin 8, type II 0.23459
UBE2I ubiquitin-conjugating enzyme E2I 0.234302
HMOX1 heme oxygenase 1 0.233731
ADAM23 ADAM metallopeptidase domain 23 0.232317
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.232039
MLXIPL MLX interacting protein-like 0.231482
ITGB7 integrin, beta 7 0.231482
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.229839
H2AFX H2A histone family, member X 0.226667
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.226411
PANX1 pannexin 1 0.224893
HIPK2 homeodomain interacting protein kinase 2 0.224893
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.224645
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.22246
CA2 carbonic anhydrase II 0.22246
MEIS2 Meis homeobox 2 0.221989
PXDN peroxidasin 0.219707
CDK8 cyclin-dependent kinase 8 0.217554
SMAD7 SMAD family member 7 0.217346
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.21673
SPAG7 sperm associated antigen 7 0.216528
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.21573
ZEB2 zinc finger E-box binding homeobox 2 0.215534
HMGA1 high mobility group AT-hook 1 0.214576
GLO1 glyoxalase I 0.214388
AQP4 aquaporin 4 0.214017
PTTG1 pituitary tumor-transforming 1 0.21365
PLEC plectin 0.213471
VIM vimentin 0.212761
MIRLET7C microRNA let-7c 0.212586
MIR184 microRNA 184 0.210603
BIN3 bridging integrator 3 0.206009
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.197679
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.197253
GDF15 growth differentiation factor 15 0.196126
GRAP2 GRB2-related adaptor protein 2 0.195886
MIR31 microRNA 31 0.195526
ACOT7 acyl-CoA thioesterase 7 0.194711
MIR222 microRNA 222 0.194433
SPPL3 signal peptide peptidase like 3 0.193998
CHKA choline kinase alpha 0.193416
RYR1 ryanodine receptor 1 (skeletal) 0.192433
HPGDS hematopoietic prostaglandin D synthase 0.191976
NPTXR neuronal pentraxin receptor 0.191415
NPR3 natriuretic peptide receptor 3 0.19079
TPT1 tumor protein, translationally-controlled 1 0.190645
UBB ubiquitin B 0.190132
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.190112
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.18931
AREG amphiregulin 0.188359
TPI1 triosephosphate isomerase 1 0.188091
GSS glutathione synthetase 0.186812
YY1 YY1 transcription factor 0.184835
MBNL1 muscleblind-like splicing regulator 1 0.179408
SIX5 SIX homeobox 5 0.177885
HEPH hephaestin 0.175668
WNT3A wingless-type MMTV integration site family, member 3A 0.175541
DAXX death-domain associated protein 0.172708
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.170347
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.169707
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.161346
EGFR epidermal growth factor receptor 0.161093
FPR1 formyl peptide receptor 1 0.159418
CD6 CD6 molecule 0.158027
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.157163
NLE1 notchless homolog 1 (Drosophila) 0.155665
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.154106
NPPC natriuretic peptide C 0.151114
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.151114
ANXA2 annexin A2 0.15077
LMNA lamin A/C 0.150655
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.150421
CDK2 cyclin-dependent kinase 2 0.149176
ITGA6 integrin, alpha 6 0.147831
CAST calpastatin 0.147519
CALD1 caldesmon 1 0.146254
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.145868