lateral sclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs. (Human Disease Ontology, DOID_230)
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Genes

55 genes co-occuring with the disease lateral sclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 2.69916
TARDBP TAR DNA binding protein 1.26429
PLEK pleckstrin 1.23603
C9ORF72 chromosome 9 open reading frame 72 1.19186
FIG4 FIG4 phosphoinositide 5-phosphatase 1.15198
UXT ubiquitously-expressed, prefoldin-like chaperone 1.11645
SOD2 superoxide dismutase 2, mitochondrial 1.1009
ERLIN2 ER lipid raft associated 2 1.07152
FUS FUS RNA binding protein 1.00794
TNPO1 transportin 1 0.997814
EEA1 early endosome antigen 1 0.97254
LMNB1 lamin B1 0.924213
MCF2 MCF.2 cell line derived transforming sequence 0.911022
UBQLN2 ubiquilin 2 0.904032
SPAST spastin 0.888848
PLS1 plastin 1 0.866321
SIGMAR1 sigma non-opioid intracellular receptor 1 0.852811
VDAC2 voltage-dependent anion channel 2 0.826178
TMEM106B transmembrane protein 106B 0.816745
MNDA myeloid cell nuclear differentiation antigen 0.786394
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.745985
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.715618
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.714811
ADNP activity-dependent neuroprotector homeobox 0.699919
LONP1 lon peptidase 1, mitochondrial 0.626495
ATXN2 ataxin 2 0.604591
MASP2 mannan-binding lectin serine peptidase 2 0.565666
SETX senataxin 0.557897
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.548583
CDK5 cyclin-dependent kinase 5 0.507273
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.505739
SOD1 superoxide dismutase 1, soluble 0.457109
GPR162 G protein-coupled receptor 162 0.453716
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.431144
CRYAA crystallin, alpha A 0.397471
PNMA2 paraneoplastic Ma antigen 2 0.37629
LAX1 lymphocyte transmembrane adaptor 1 0.346409
CST3 cystatin C 0.334315
DES desmin 0.307033
MSTN myostatin 0.30631
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.30342
ANG angiogenin, ribonuclease, RNase A family, 5 0.297651
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.290821
MGAM maltase-glucoamylase 0.257005
MPZ myelin protein zero 0.246098
MUSK muscle, skeletal, receptor tyrosine kinase 0.241196
SP1 Sp1 transcription factor 0.233878
CALB1 calbindin 1, 28kDa 0.198709
MAPT microtubule-associated protein tau 0.191719
PVALB parvalbumin 0.191719
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.18621
HEXA hexosaminidase A (alpha polypeptide) 0.163938
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.162908
CDK1 cyclin-dependent kinase 1 0.159124
FLNA filamin A, alpha 0.158097