larynx cancer Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A respiratory system cancer that is located_in the larynx. (Human Disease Ontology, DOID_2596)
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Genes

381 genes co-occuring with the disease larynx cancer in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PDPN podoplanin 2.00056
TP53 tumor protein p53 1.61754
GGNBP2 gametogenetin binding protein 2 1.37948
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 1.30314
PCNA proliferating cell nuclear antigen 1.28523
BIRC5 baculoviral IAP repeat containing 5 1.23343
CCND1 cyclin D1 1.22432
EGFR epidermal growth factor receptor 1.15965
GSTT1 glutathione S-transferase theta 1 1.13205
GSTTP1 glutathione S-transferase theta pseudogene 1 1.13205
CDKN2A cyclin-dependent kinase inhibitor 2A 1.05471
CAMSAP1 calmodulin regulated spectrin-associated protein 1 1.04335
MYCT1 myc target 1 1.04293
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.03872
GSTM1 glutathione S-transferase mu 1 1.02397
MIS18BP1 MIS18 binding protein 1 1.02102
NBL1 neuroblastoma 1, DAN family BMP antagonist 1.01427
TFG TRK-fused gene 1.00583
DHRS11 dehydrogenase/reductase (SDR family) member 11 0.958287
STOML2 stomatin (EPB72)-like 2 0.956614
MMP2 matrix metallopeptidase 2 0.947852
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 0.947019
VEGFC vascular endothelial growth factor C 0.915963
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.915551
GSTM3 glutathione S-transferase mu 3 (brain) 0.903621
BCL2 B-cell CLL/lymphoma 2 0.899514
RPL24 ribosomal protein L24 0.8741
EIF4E eukaryotic translation initiation factor 4E 0.860999
CD6 CD6 molecule 0.850764
CD82 CD82 molecule 0.841753
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 0.836837
PROM1 prominin 1 0.813462
CD44 CD44 molecule (Indian blood group) 0.806077
CTSD cathepsin D 0.800333
TERT telomerase reverse transcriptase 0.792131
MIR93 microRNA 93 0.784345
GSTA1 glutathione S-transferase alpha 1 0.778204
ZNF706 zinc finger protein 706 0.777795
PTEN phosphatase and tensin homolog 0.772479
MIR21 microRNA 21 0.771661
FHIT fragile histidine triad 0.758601
GSTA3 glutathione S-transferase alpha 3 0.756156
GSTA2 glutathione S-transferase alpha 2 0.754934
GSTA4 glutathione S-transferase alpha 4 0.753713
MKI67 marker of proliferation Ki-67 0.735027
ZFX zinc finger protein, X-linked 0.729357
MMP9 matrix metallopeptidase 9 0.724098
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.716021
FOXN3 forkhead box N3 0.710378
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.705144
BAX BCL2-associated X protein 0.695103
ZNF135 zinc finger protein 135 0.694301
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.692296
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.684292
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.6791
ENG endoglin 0.673518
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.672722
TCHP trichoplein, keratin filament binding 0.66596
BRMS1 breast cancer metastasis suppressor 1 0.6608
BRMS1L breast cancer metastasis-suppressor 1-like 0.659611
FLT4 fms-related tyrosine kinase 4 0.658422
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.652089
LCE3D late cornified envelope 3D 0.651694
HPGDS hematopoietic prostaglandin D synthase 0.650508
OAF OAF homolog (Drosophila) 0.647348
RPL31 ribosomal protein L31 0.638676
SH3GL2 SH3-domain GRB2-like 2 0.638282
ECM1 extracellular matrix protein 1 0.629242
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.608494
TGM3 transglutaminase 3 0.607323
ZMYND11 zinc finger, MYND-type containing 11 0.58939
PRR20E proline rich 20E 0.588222
PRR20C proline rich 20C 0.588222
CALML3 calmodulin-like 3 0.581606
COPS5 COP9 signalosome subunit 5 0.577327
S100A2 S100 calcium binding protein A2 0.573828
KIF14 kinesin family member 14 0.567609
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.56722
PRR20A proline rich 20A 0.565666
FSCN3 fascin actin-bundling protein 3, testicular 0.565277
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.564112
EGFL7 EGF-like-domain, multiple 7 0.561781
ILK integrin-linked kinase 0.553239
MIR203A microRNA 203a 0.552463
CHSY3 chondroitin sulfate synthase 3 0.552075
STK17A serine/threonine kinase 17a 0.543542
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.538506
FSCN2 fascin actin-bundling protein 2, retinal 0.537731
VEGFA vascular endothelial growth factor A 0.537344
ELAVL1 ELAV like RNA binding protein 1 0.535796
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.531928
ACAN aggrecan 0.526904
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.52536
PLAU plasminogen activator, urokinase 0.517265
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.514956
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.508424
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.505739
MCM7 minichromosome maintenance complex component 7 0.504973
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.499231
LY6D lymphocyte antigen 6 complex, locus D 0.495793
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.494648
GJB5 gap junction protein, beta 5, 31.1kDa 0.489311
CD200R1 CD200 receptor 1 0.484364
LGALS8 lectin, galactoside-binding, soluble, 8 0.483604
CHD5 chromodomain helicase DNA binding protein 5 0.481705
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.480186
IFNA17 interferon, alpha 17 0.479047
DKKL1 dickkopf-like 1 0.47753
MTDH metadherin 0.477151
VCAN versican 0.472982
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.468819
MMP8 matrix metallopeptidase 8 0.458241
NCL nucleolin 0.457109
MCM2 minichromosome maintenance complex component 2 0.455978
MIR19A microRNA 19a 0.452962
CDK2 cyclin-dependent kinase 2 0.451454
HMGB1 high mobility group box 1 0.450701
FSCN1 fascin actin-bundling protein 1 0.440162
PCDH17 protocadherin 17 0.439786
GSTP1 glutathione S-transferase pi 1 0.43753
TIMP1 TIMP metallopeptidase inhibitor 1 0.430393
TSPO translocator protein (18kDa) 0.428516
MET MET proto-oncogene, receptor tyrosine kinase 0.426265
MMP1 matrix metallopeptidase 1 0.422515
ANG angiogenin, ribonuclease, RNase A family, 5 0.421765
KRT13 keratin 13, type I 0.418768
S100A3 S100 calcium binding protein A3 0.413901
ITGA8 integrin, alpha 8 0.413901
BCAR3 breast cancer anti-estrogen resistance 3 0.407919
RHOQ ras homolog family member Q 0.407545
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.405305
DCN decorin 0.403064
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.396725
S100A11 S100 calcium binding protein A11 0.394118
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.393746
BSG basigin (Ok blood group) 0.393001
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.386679
CCL19 chemokine (C-C motif) ligand 19 0.386308
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.385193
MAGEA9 melanoma antigen family A9 0.384451
MAGEA9B melanoma antigen family A9B 0.384451
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.383708
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.383708
EZR ezrin 0.379256
KRT31 keratin 31, type I 0.378514
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.374809
RBP1 retinol binding protein 1, cellular 0.374438
RPE ribulose-5-phosphate-3-epimerase 0.374438
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.369628
ERBB2 erb-b2 receptor tyrosine kinase 2 0.369258
GSTM4 glutathione S-transferase mu 4 0.364454
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.358551
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.357446
MAL mal, T-cell differentiation protein 0.354868
IFNA21 interferon, alpha 21 0.351923
GPR176 G protein-coupled receptor 176 0.350084
LVRN laeverin 0.350084
ITGAV integrin, alpha V 0.349349
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.347144
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.346777
LGALS3 lectin, galactoside-binding, soluble, 3 0.346042
TADA3 transcriptional adaptor 3 0.345675
SP140 SP140 nuclear body protein 0.344207
ANXA5 annexin A5 0.34384
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.343473
EMILIN1 elastin microfibril interfacer 1 0.340906
AHNAK AHNAK nucleoprotein 0.336144
HBA1 hemoglobin, alpha 1 0.336144
RARB retinoic acid receptor, beta 0.335778
ULBP3 UL16 binding protein 3 0.333949
YARS tyrosyl-tRNA synthetase 0.32993
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 0.3292
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.3292
USP22 ubiquitin specific peptidase 22 0.324094
KRT8 keratin 8, type II 0.322273
DAPK1 death-associated protein kinase 1 0.321909
CD83 CD83 molecule 0.315003
HBA2 hemoglobin, alpha 2 0.315003
CCL21 chemokine (C-C motif) ligand 21 0.315003
CA9 carbonic anhydrase IX 0.307757
PCCA propionyl CoA carboxylase, alpha polypeptide 0.302337
PFDN4 prefoldin subunit 4 0.302337
MTA1 metastasis associated 1 0.302337
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.301615
CCR6 chemokine (C-C motif) receptor 6 0.300894
CCR7 chemokine (C-C motif) receptor 7 0.300894
SOX2 SRY (sex determining region Y)-box 2 0.299452
ADAM12 ADAM metallopeptidase domain 12 0.299092
GCAT glycine C-acetyltransferase 0.298371
RHOB ras homolog family member B 0.297651
RUNX3 runt-related transcription factor 3 0.290103
MUS81 MUS81 structure-specific endonuclease subunit 0.282582
CD200 CD200 molecule 0.282225
MLH1 mutL homolog 1 0.280082
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.27687
OGN osteoglycin 0.276158
STC2 stanniocalcin 2 0.274732
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.270464
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.269753
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.268332
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.267977
S100A4 S100 calcium binding protein A4 0.265849
MFAP2 microfibrillar-associated protein 2 0.264785
MCM4 minichromosome maintenance complex component 4 0.264785
TIMP2 TIMP metallopeptidase inhibitor 2 0.25983
HLA-A major histocompatibility complex, class I, A 0.25877
CTCF CCCTC-binding factor (zinc finger protein) 0.258417
SOCS1 suppressor of cytokine signaling 1 0.258417
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.257005
S100A8 S100 calcium binding protein A8 0.254888
PLAGL2 pleiomorphic adenoma gene-like 2 0.254888
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.254183
S100A7 S100 calcium binding protein A7 0.254183
RECQL5 RecQ protein-like 5 0.252422
CD4 CD4 molecule 0.25207
MT1E metallothionein 1E 0.249608
CD34 CD34 molecule 0.248203
FN1 fibronectin 1 0.24715
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.245747
BAG1 BCL2-associated athanogene 0.245396
CCL20 chemokine (C-C motif) ligand 20 0.242945
RPL22 ribosomal protein L22 0.242245
CA1 carbonic anhydrase I 0.240847
TRAF3 TNF receptor-associated factor 3 0.238054
TNC tenascin C 0.238054
BMF Bcl2 modifying factor 0.237706
FOXM1 forkhead box M1 0.236312
NDRG1 N-myc downstream regulated 1 0.226262
AMY1B amylase, alpha 1B (salivary) 0.221793
AMY1A amylase, alpha 1A (salivary) 0.221793
AMY1C amylase, alpha 1C (salivary) 0.221793
HDAC6 histone deacetylase 6 0.22145
HLA-C major histocompatibility complex, class I, C 0.220766
IRF6 interferon regulatory factor 6 0.219057
PGRMC1 progesterone receptor membrane component 1 0.219057
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.217693
ITGA6 integrin, alpha 6 0.217012
ACTB actin, beta 0.217012
PDE8B phosphodiesterase 8B 0.216672
BCL2L1 BCL2-like 1 0.216332
SRY sex determining region Y 0.215992
PTK6 protein tyrosine kinase 6 0.215314
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.214975
DUSP4 dual specificity phosphatase 4 0.214636
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.212945
CD109 CD109 molecule 0.211597
MMP12 matrix metallopeptidase 12 0.211597
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.211261
TFRC transferrin receptor 0.211261
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.210253
TMPRSS13 transmembrane protease, serine 13 0.210253
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.209918
CXCR4 chemokine (C-X-C motif) receptor 4 0.20658
FRY furry homolog (Drosophila) 0.205916
CAPN10 calpain 10 0.204593
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.203604
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.203275
DNTT DNA nucleotidylexotransferase 0.203275
IFNA2 interferon, alpha 2 0.203275
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.202946
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.20229
FOXP3 forkhead box P3 0.197742
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.1936
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.191408
ACTG1 actin gamma 1 0.190786
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.190786
LAMB2 laminin, beta 2 (laminin S) 0.18591
TENM1 teneurin transmembrane protein 1 0.185612
COL14A1 collagen, type XIV, alpha 1 0.185016
AURKA aurora kinase A 0.183835
SENP1 SUMO1/sentrin specific peptidase 1 0.183541
CSN1S1 casein alpha s1 0.183541
MMP20 matrix metallopeptidase 20 0.180937
CCNG2 cyclin G2 0.180652
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.179802
KRT4 keratin 4, type II 0.178403
CTSB cathepsin B 0.177301
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.176215
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.175146
CSTB cystatin B (stefin B) 0.174617
ATM ATM serine/threonine kinase 0.173832
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.173832
AQP1 aquaporin 1 (Colton blood group) 0.173314
PDCD5 programmed cell death 5 0.173057
TGFB1 transforming growth factor, beta 1 0.172291
COX5A cytochrome c oxidase subunit Va 0.170299
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.168381
ZYX zyxin 0.167682
HSPA4 heat shock 70kDa protein 4 0.166995
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.166768
PCDH11Y protocadherin 11 Y-linked 0.164571
MCM3 minichromosome maintenance complex component 3 0.163523
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.162505
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.160021
OXA1L oxidase (cytochrome c) assembly 1-like 0.15948
PGR progesterone receptor 0.158605
CD27 CD27 molecule 0.158097
HPD 4-hydroxyphenylpyruvate dioxygenase 0.143286
PIDD1 p53-induced death domain protein 1 0.142125
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.140012
ACOT13 acyl-CoA thioesterase 13 0.139386
THBS2 thrombospondin 2 0.138425
DGCR8 DGCR8 microprocessor complex subunit 0.138138
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.137321
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.136677
ETV4 ets variant 4 0.135948
TXNL4B thioredoxin-like 4B 0.133621
KRT16 keratin 16, type I 0.133376
TIMP4 TIMP metallopeptidase inhibitor 4 0.133337
MMP10 matrix metallopeptidase 10 0.132499
CTSL cathepsin L 0.130611
CNN1 calponin 1, basic, smooth muscle 0.129917
TAGLN transgelin 0.124646
CD9 CD9 molecule 0.124137
ENO1 enolase 1, (alpha) 0.123846
MMP7 matrix metallopeptidase 7 0.12
TPBG trophoblast glycoprotein 0.117396
ACPP acid phosphatase, prostate 0.117127
CTCFL CCCTC-binding factor (zinc finger protein)-like 0.116257
GP5 glycoprotein V (platelet) 0.115593
SATB2 SATB homeobox 2 0.115337
ITGB8 integrin, beta 8 0.114633
HMGA2 high mobility group AT-hook 2 0.114404
CCNG1 cyclin G1 0.113946
ADCY6 adenylate cyclase 6 0.113439
PCDH11X protocadherin 11 X-linked 0.113321
LST1 leukocyte specific transcript 1 0.113262
ING1 inhibitor of growth family, member 1 0.113125
HTN3 histatin 3 0.112746
KRT19 keratin 19, type I 0.1111
CD2 CD2 molecule 0.108803
RXRA retinoid X receptor, alpha 0.107843
NOS2 nitric oxide synthase 2, inducible 0.106475
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.106211
CFD complement factor D (adipsin) 0.102698
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.088061
COL17A1 collagen, type XVII, alpha 1 0.086556
MLH3 mutL homolog 3 0.08636
CCNB1 cyclin B1 0.085928
ZFY zinc finger protein, Y-linked 0.085728
PXN paxillin 0.085462
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.085196
MYBPC1 myosin binding protein C, slow type 0.085163
MST1 macrophage stimulating 1 0.085129
SATB1 SATB homeobox 1 0.084996
ENO2 enolase 2 (gamma, neuronal) 0.084797
INPPL1 inositol polyphosphate phosphatase-like 1 0.083718
TAPBP TAP binding protein (tapasin) 0.083684
MGMT O-6-methylguanine-DNA methyltransferase 0.083041
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.082358
PLK2 polo-like kinase 2 0.082153
F8 coagulation factor VIII, procoagulant component 0.081914
KLK11 kallikrein-related peptidase 11 0.081744
GSTM2 glutathione S-transferase mu 2 (muscle) 0.081675
MAPK3 mitogen-activated protein kinase 3 0.08164
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.081606
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.081537
ARHGAP1 Rho GTPase activating protein 1 0.081364
BST2 bone marrow stromal cell antigen 2 0.080328
CCND3 cyclin D3 0.078794
IGFBP7 insulin-like growth factor binding protein 7 0.078374
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.078303
MUC1 mucin 1, cell surface associated 0.078056
A4GALT alpha 1,4-galactosyltransferase 0.077352
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.077211
HRAS Harvey rat sarcoma viral oncogene homolog 0.077211
ENDOG endonuclease G 0.077141
KLK4 kallikrein-related peptidase 4 0.076787
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.076751
BTG2 BTG family, member 2 0.076716
MIR10A microRNA 10a 0.07668
CCNA1 cyclin A1 0.076609
STC1 stanniocalcin 1 0.076573
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.076431
COL4A2 collagen, type IV, alpha 2 0.076182
CFL1 cofilin 1 (non-muscle) 0.075685
KRT9 keratin 9, type I 0.07565
ERBB3 erb-b2 receptor tyrosine kinase 3 0.075614
PRKCZ protein kinase C, zeta 0.075294
BIRC7 baculoviral IAP repeat containing 7 0.074721
RERE arginine-glutamic acid dipeptide (RE) repeats 0.074613