large cell carcinoma cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A group of lung cancers in which the cells are large and look abnormal. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002059)
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Genes

256 proteins co-occuring with the tissue large cell carcinoma cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 2.05568
USP25 ubiquitin specific peptidase 25 1.55358
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 1.391
MED19 mediator complex subunit 19 1.33681
MIRLET7C microRNA let-7c 1.03785
NPC2 Niemann-Pick disease, type C2 0.818576
PDE4A phosphodiesterase 4A, cAMP-specific 0.808134
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.747102
HMGA1 high mobility group AT-hook 1 0.675765
TOP3A topoisomerase (DNA) III alpha 0.67495
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.589635
SRSF1 serine/arginine-rich splicing factor 1 0.57042
TP53 tumor protein p53 0.568424
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.548676
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.535438
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.514687
ACTB actin, beta 0.507457
RTN1 reticulon 1 0.503926
ACTG1 actin gamma 1 0.488276
ADPGK ADP-dependent glucokinase 0.488042
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.48087
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.473636
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.470763
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.450118
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.444884
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.437205
TYMP thymidine phosphorylase 0.424199
GSTM2 glutathione S-transferase mu 2 (muscle) 0.407073
NKX2-1 NK2 homeobox 1 0.396844
BAX BCL2-associated X protein 0.378898
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.375368
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.363393
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.345854
HRAS Harvey rat sarcoma viral oncogene homolog 0.324605
PARP1 poly (ADP-ribose) polymerase 1 0.32132
RNF111 ring finger protein 111 0.314191
BIRC5 baculoviral IAP repeat containing 5 0.308684
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.303126
BCL2L1 BCL2-like 1 0.30219
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.301974
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.29673
FAM133A family with sequence similarity 133, member A 0.294009
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.288585
H2AFX H2A histone family, member X 0.28312
CCPG1 cell cycle progression 1 0.280788
TAGLN2 transgelin 2 0.279025
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.274604
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.274394
CDCA7L cell division cycle associated 7-like 0.272509
ANXA5 annexin A5 0.26655
TOP1 topoisomerase (DNA) I 0.259456
CERS2 ceramide synthase 2 0.2559
BCL2 B-cell CLL/lymphoma 2 0.254504
WBSCR22 Williams Beuren syndrome chromosome region 22 0.252787
DIABLO diablo, IAP-binding mitochondrial protein 0.25213
SESN2 sestrin 2 0.245554
CAV1 caveolin 1, caveolae protein, 22kDa 0.241561
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.236098
EGFR epidermal growth factor receptor 0.233959
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 0.233845
TSPYL5 TSPY-like 5 0.232374
TP53I3 tumor protein p53 inducible protein 3 0.229085
DDIT3 DNA-damage-inducible transcript 3 0.228604
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.226565
CTSB cathepsin B 0.221291
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.220923
TSPYL4 TSPY-like 4 0.220468
CCNB1 cyclin B1 0.220197
SEBOX SEBOX homeobox 0.219928
KIAA1524 KIAA1524 0.2187
CDK4 cyclin-dependent kinase 4 0.215341
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.213944
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.209069
PTEN phosphatase and tensin homolog 0.208175
MDM4 MDM4, p53 regulator 0.206739
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.204708
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.203692
FADD Fas (TNFRSF6)-associated via death domain 0.202888
CDK1 cyclin-dependent kinase 1 0.202701
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.20195
ROMO1 reactive oxygen species modulator 1 0.20129
ATG5 autophagy related 5 0.200902
EML4 echinoderm microtubule associated protein like 4 0.200752
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.20073
CCAR1 cell division cycle and apoptosis regulator 1 0.200545
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.200092
RARG retinoic acid receptor, gamma 0.199901
SKIL SKI-like proto-oncogene 0.199736
PDIA4 protein disulfide isomerase family A, member 4 0.199673
HDAC4 histone deacetylase 4 0.199657
MDC1 mediator of DNA-damage checkpoint 1 0.199641
BECN1 beclin 1, autophagy related 0.199019
TUBA1B tubulin, alpha 1b 0.198614
HDAC9 histone deacetylase 9 0.198473
MIR98 microRNA 98 0.198462
DDIT4 DNA-damage-inducible transcript 4 0.198389
ZNF148 zinc finger protein 148 0.19815
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.198145
PLK2 polo-like kinase 2 0.197937
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.197834
CDC25C cell division cycle 25C 0.197764
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.197683
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.197616
SARS seryl-tRNA synthetase 0.197616
AMBP alpha-1-microglobulin/bikunin precursor 0.19757
FHIT fragile histidine triad 0.197467
DUSP1 dual specificity phosphatase 1 0.197434
FBXO17 F-box protein 17 0.197418
CLSPN claspin 0.197377
DCK deoxycytidine kinase 0.197012
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.196894
RUNX3 runt-related transcription factor 3 0.196894
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.196556
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.196548
KRAS Kirsten rat sarcoma viral oncogene homolog 0.196512
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.196484
CDC25B cell division cycle 25B 0.196396
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.196372
GADD45A growth arrest and DNA-damage-inducible, alpha 0.196087
TOPBP1 topoisomerase (DNA) II binding protein 1 0.195987
FAF1 Fas (TNFRSF6) associated factor 1 0.195895
CCND1 cyclin D1 0.195793
ATM ATM serine/threonine kinase 0.195775
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.195767
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.19547
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.195416
IL17RA interleukin 17 receptor A 0.195353
FASLG Fas ligand (TNF superfamily, member 6) 0.195058
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.195002
DRD5 dopamine receptor D5 0.19482
DKK4 dickkopf WNT signaling pathway inhibitor 4 0.194654
CA4 carbonic anhydrase IV 0.194549
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.194464
COL18A1 collagen, type XVIII, alpha 1 0.194352
XBP1 X-box binding protein 1 0.194248
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.193936
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.193898
IGFBP3 insulin-like growth factor binding protein 3 0.193844
TRAF4 TNF receptor-associated factor 4 0.193789
CDK2 cyclin-dependent kinase 2 0.193622
RARB retinoic acid receptor, beta 0.193622
AXIN1 axin 1 0.193464
NQO1 NAD(P)H dehydrogenase, quinone 1 0.193349
CTNND1 catenin (cadherin-associated protein), delta 1 0.193349
MVD mevalonate (diphospho) decarboxylase 0.193349
OCA2 oculocutaneous albinism II 0.193268
THAP1 THAP domain containing, apoptosis associated protein 1 0.193163
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.192996
DDB2 damage-specific DNA binding protein 2, 48kDa 0.192936
BACE2 beta-site APP-cleaving enzyme 2 0.192875
SFRP1 secreted frizzled-related protein 1 0.19279
HK2 hexokinase 2 0.192765
VDAC2 voltage-dependent anion channel 2 0.192691
HDAC3 histone deacetylase 3 0.192629
GDF15 growth differentiation factor 15 0.192591
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.192579
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.192375
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.19235
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.192181
AKAP12 A kinase (PRKA) anchor protein 12 0.192129
MGMT O-6-methylguanine-DNA methyltransferase 0.192102
TGFBR3 transforming growth factor, beta receptor III 0.192036
FDXR ferredoxin reductase 0.191889
PTK6 protein tyrosine kinase 6 0.191726
INHBA inhibin, beta A 0.191726
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.191643
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.191608
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.191349
GSK3A glycogen synthase kinase 3 alpha 0.191349
RXRA retinoid X receptor, alpha 0.191263
CFLAR CASP8 and FADD-like apoptosis regulator 0.19122
STK38 serine/threonine kinase 38 0.191177
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.191162
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.19106
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.191031
BIRC2 baculoviral IAP repeat containing 2 0.191009
ADAM8 ADAM metallopeptidase domain 8 0.190943
HDAC8 histone deacetylase 8 0.190628
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.190489
IL24 interleukin 24 0.190104
UBC ubiquitin C 0.189984
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.189967
YY1 YY1 transcription factor 0.189967
PLK1 polo-like kinase 1 0.189902
BMPR1B bone morphogenetic protein receptor, type IB 0.189886
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.189821
RPS27A ribosomal protein S27a 0.189796
EIF4H eukaryotic translation initiation factor 4H 0.189738
EIF4B eukaryotic translation initiation factor 4B 0.189247
CRYZ crystallin, zeta (quinone reductase) 0.18923
UBB ubiquitin B 0.189116
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.188823
MMP7 matrix metallopeptidase 7 0.188805
CCNE2 cyclin E2 0.188805
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.188769
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.188769
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.188569
TCTEX1D4 Tctex1 domain containing 4 0.188439
HYOU1 hypoxia up-regulated 1 0.18843
PNMA1 paraneoplastic Ma antigen 1 0.188175
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.188127
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.187905
DNTT DNA nucleotidylexotransferase 0.187767
ACTC1 actin, alpha, cardiac muscle 1 0.187385
CCND3 cyclin D3 0.187365
CDKN2A cyclin-dependent kinase inhibitor 2A 0.187043
TOP2B topoisomerase (DNA) II beta 180kDa 0.186948
EGR1 early growth response 1 0.186819
ADM2 adrenomedullin 2 0.186733
TIMELESS timeless circadian clock 0.18669
ERCC4 excision repair cross-complementation group 4 0.186581
TXNL1 thioredoxin-like 1 0.186493
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.186326
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.186247
CAT catalase 0.186224
CHEK1 checkpoint kinase 1 0.186179
SIL1 SIL1 nucleotide exchange factor 0.186156
TUBB4B tubulin, beta 4B class IVb 0.185856
ERCC5 excision repair cross-complementation group 5 0.185856
CXCL3 chemokine (C-X-C motif) ligand 3 0.185833
IGF1R insulin-like growth factor 1 receptor 0.185739
MIR21 microRNA 21 0.185258
SNW1 SNW domain containing 1 0.183809
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.181455
HDAC1 histone deacetylase 1 0.181168
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.18025
CD59 CD59 molecule, complement regulatory protein 0.179186
MMP2 matrix metallopeptidase 2 0.178967
SFN stratifin 0.178946
CLIC4 chloride intracellular channel 4 0.178435
GSTP1 glutathione S-transferase pi 1 0.177553
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.177464
CETN2 centrin, EF-hand protein, 2 0.175486
MET MET proto-oncogene, receptor tyrosine kinase 0.175179
YBX3 Y box binding protein 3 0.173741
SBDS Shwachman-Bodian-Diamond syndrome 0.171403
CLIC1 chloride intracellular channel 1 0.169565
YARS tyrosyl-tRNA synthetase 0.167537
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.16722
H3F3A H3 histone, family 3A 0.166735
H3F3B H3 histone, family 3B (H3.3B) 0.166735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.166571
AMER1 APC membrane recruitment protein 1 0.161945
DYNLT1 dynein, light chain, Tctex-type 1 0.160564
GMNN geminin, DNA replication inhibitor 0.160407
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.159499
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.159174
CDK6 cyclin-dependent kinase 6 0.159119
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.158952
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.158729
TYRO3 TYRO3 protein tyrosine kinase 0.158673
PKM pyruvate kinase, muscle 0.157366
WWOX WW domain containing oxidoreductase 0.157133
CXCL12 chemokine (C-X-C motif) ligand 12 0.156422
WIF1 WNT inhibitory factor 1 0.156123
BAD BCL2-associated agonist of cell death 0.155573