lansoprazole-7306 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lansoprazole-7306 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGAP26 Rho GTPase activating protein 26
ARHGAP6 Rho GTPase activating protein 6
ASTN2 astrotactin 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C4BPA complement component 4 binding protein, alpha
CA6 carbonic anhydrase VI
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCNO cyclin O
CD6 CD6 molecule
CDC14A cell division cycle 14A
CDK3 cyclin-dependent kinase 3
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CIB2 calcium and integrin binding family member 2
COL11A2 collagen, type XI, alpha 2
CPN2 carboxypeptidase N, polypeptide 2
CTNND2 catenin (cadherin-associated protein), delta 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSTYK dual serine/threonine and tyrosine protein kinase
DVL3 dishevelled segment polarity protein 3
DZIP1 DAZ interacting zinc finger protein 1
EGFR epidermal growth factor receptor
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERAP1 endoplasmic reticulum aminopeptidase 1
ESRRG estrogen-related receptor gamma
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO21 F-box protein 21
GAB1 GRB2-associated binding protein 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGT1 gamma-glutamyltransferase 1
GPC1 glypican 1
GPR107 G protein-coupled receptor 107
GREB1L growth regulation by estrogen in breast cancer-like
HAMP hepcidin antimicrobial peptide
HAP1 huntingtin-associated protein 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1E histone cluster 1, H1e
HLA-DOA major histocompatibility complex, class II, DO alpha
HOMER3 homer scaffolding protein 3
HOXA4 homeobox A4
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ING4 inhibitor of growth family, member 4
ITGA10 integrin, alpha 10
ITGB8 integrin, beta 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIMK2 LIM domain kinase 2
LINC00341 long intergenic non-protein coding RNA 341
LRP1 low density lipoprotein receptor-related protein 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NAAA N-acylethanolamine acid amidase
NEO1 neogenin 1
NNMT nicotinamide N-methyltransferase
NRF1 nuclear respiratory factor 1
NT5M 5',3'-nucleotidase, mitochondrial
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PDGFB platelet-derived growth factor beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX6 peroxisomal biogenesis factor 6
PIP prolactin-induced protein
PLIN2 perilipin 2
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRKCE protein kinase C, epsilon
RIMBP2 RIMS binding protein 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D2A SH2 domain containing 2A
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPTAN1 spectrin, alpha, non-erythrocytic 1
SS18 synovial sarcoma translocation, chromosome 18
STAC SH3 and cysteine rich domain
STS steroid sulfatase (microsomal), isozyme S
TADA2A transcriptional adaptor 2A
TJAP1 tight junction associated protein 1 (peripheral)
TUBA4B tubulin, alpha 4b
UBXN1 UBX domain protein 1
ULK2 unc-51 like autophagy activating kinase 2
XYLB xylulokinase homolog (H. influenzae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF609 zinc finger protein 609
ZNF747 zinc finger protein 747
ZNF821 zinc finger protein 821
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ACOT8 acyl-CoA thioesterase 8
AHDC1 AT hook, DNA binding motif, containing 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANXA10 annexin A10
ANXA2P3 annexin A2 pseudogene 3
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATG2A autophagy related 2A
AVEN apoptosis, caspase activation inhibitor
BCOR BCL6 corepressor
BOLA1 bolA family member 1
C19ORF54 chromosome 19 open reading frame 54
C3ORF52 chromosome 3 open reading frame 52
CACTIN cactin, spliceosome C complex subunit
CINP cyclin-dependent kinase 2 interacting protein
COQ4 coenzyme Q4
CTSD cathepsin D
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK1 delta-like 1 homolog (Drosophila)
ELOVL4 ELOVL fatty acid elongase 4
ERF Ets2 repressor factor
FAM160B2 family with sequence similarity 160, member B2
FBXO2 F-box protein 2
FBXW4 F-box and WD repeat domain containing 4
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGD6 FYVE, RhoGEF and PH domain containing 6
FXN frataxin
GMIP GEM interacting protein
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HAUS6 HAUS augmin-like complex, subunit 6
HHLA3 HERV-H LTR-associating 3
HOXC13 homeobox C13
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPB8 heat shock 22kDa protein 8
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF2 interferon regulatory factor 2
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KIAA0894 KIAA0894 protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX6 LIM homeobox 6
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAP9 microtubule-associated protein 9
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL2B methyltransferase like 2B
MXD3 MAX dimerization protein 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NLK nemo-like kinase
NT5DC3 5'-nucleotidase domain containing 3
OLFML2A olfactomedin-like 2A
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYOX1L prenylcysteine oxidase 1 like
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTDSS2 phosphatidylserine synthase 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF121 ring finger protein 121
RPUSD2 RNA pseudouridylate synthase domain containing 2
SAMHD1 SAM domain and HD domain 1
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG9 SMG9 nonsense mediated mRNA decay factor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNHG20 small nucleolar RNA host gene 20
SNX16 sorting nexin 16
SPAG4 sperm associated antigen 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRBD1 S1 RNA binding domain 1
STAR steroidogenic acute regulatory protein
THBS3 thrombospondin 3
TKFC triokinase/FMN cyclase
TM7SF2 transmembrane 7 superfamily member 2
TNNI3 troponin I type 3 (cardiac)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPST2 tyrosylprotein sulfotransferase 2
TRAIP TRAF interacting protein
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN1 tetraspanin 1
USP27X ubiquitin specific peptidase 27, X-linked
USP6 ubiquitin specific peptidase 6
WDR37 WD repeat domain 37
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB44 zinc finger and BTB domain containing 44
ZNF580 zinc finger protein 580