lansoprazole-3529 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lansoprazole-3529 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADRA1A adrenoceptor alpha 1A
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APOM apolipoprotein M
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARMC4 armadillo repeat containing 4
ARTN artemin
ATAT1 alpha tubulin acetyltransferase 1
ATF6B activating transcription factor 6 beta
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC134 coiled-coil domain containing 134
CCDC85B coiled-coil domain containing 85B
CD83 CD83 molecule
CD8A CD8a molecule
CD93 CD93 molecule
CDC25C cell division cycle 25C
COL1A1 collagen, type I, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTBP2 C-terminal binding protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
ESRRA estrogen-related receptor alpha
FADS2 fatty acid desaturase 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FOXN3 forkhead box N3
FXYD2 FXYD domain containing ion transport regulator 2
FZD1 frizzled class receptor 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPM6A glycoprotein M6A
GPR157 G protein-coupled receptor 157
HAMP hepcidin antimicrobial peptide
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HFE hemochromatosis
HLA-C major histocompatibility complex, class I, C
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
ICOSLG inducible T-cell co-stimulator ligand
IQCG IQ motif containing G
KIAA1456 KIAA1456
KLHL22 kelch-like family member 22
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMAN1 lectin, mannose-binding, 1
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MATN1 matrilin 1, cartilage matrix protein
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCOR2 nuclear receptor corepressor 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PCDHGA10 protocadherin gamma subfamily A, 10
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLEC plectin
POMT2 protein-O-mannosyltransferase 2
PPP5C protein phosphatase 5, catalytic subunit
PROL1 proline rich, lacrimal 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCAN3 RCAN family member 3
RGR retinal G protein coupled receptor
RHOH ras homolog family member H
RIN1 Ras and Rab interactor 1
RND1 Rho family GTPase 1
RND2 Rho family GTPase 2
RPS3A ribosomal protein S3A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
RYR2 ryanodine receptor 2 (cardiac)
SDC3 syndecan 3
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIRT3 sirtuin 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMAD6 SMAD family member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPN sialophorin
ST5 suppression of tumorigenicity 5
STARD8 StAR-related lipid transfer (START) domain containing 8
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMC6 transmembrane channel-like 6
TMEM63A transmembrane protein 63A
TMPRSS4 transmembrane protease, serine 4
TRIL TLR4 interactor with leucine-rich repeats
TRIM3 tripartite motif containing 3
VIPR1 vasoactive intestinal peptide receptor 1
VN1R1 vomeronasal 1 receptor 1
ZER1 zyg-11 related, cell cycle regulator
ZIC3 Zic family member 3
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ASPN asporin
BCORL1 BCL6 corepressor-like 1
C17ORF80 chromosome 17 open reading frame 80
C8ORF60 chromosome 8 open reading frame 60
CCDC25 coiled-coil domain containing 25
CCDC69 coiled-coil domain containing 69
CCP110 centriolar coiled coil protein 110kDa
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CDR2L cerebellar degeneration-related protein 2-like
CFAP44 cilia and flagella associated protein 44
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCA1 chloride channel accessory 1
CLK1 CDC-like kinase 1
CLSPN claspin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRLF1 cytokine receptor-like factor 1
CRY2 cryptochrome circadian clock 2
CUEDC1 CUE domain containing 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
EPHA2 EPH receptor A2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM46C family with sequence similarity 46, member C
FANCE Fanconi anemia, complementation group E
FLNC filamin C, gamma
FRMD1 FERM domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALK1 galactokinase 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
HIST1H2AL histone cluster 1, H2al
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPN hepsin
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IRAK4 interleukin-1 receptor-associated kinase 4
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KLK5 kallikrein-related peptidase 5
LARP6 La ribonucleoprotein domain family, member 6
LAX1 lymphocyte transmembrane adaptor 1
LHX6 LIM homeobox 6
LYRM9 LYR motif containing 9
MAGEA3 melanoma antigen family A3
METTL2B methyltransferase like 2B
MFSD11 major facilitator superfamily domain containing 11
NAV2 neuron navigator 2
NNAT neuronatin
NPM3 nucleophosmin/nucleoplasmin 3
OCLM oculomedin
PALM paralemmin
PDE8B phosphodiesterase 8B
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POM121 POM121 transmembrane nucleoporin
PROS1 protein S (alpha)
PVRL3 poliovirus receptor-related 3
RAB3A RAB3A, member RAS oncogene family
RNF170 ring finger protein 170
RNF43 ring finger protein 43
ROM1 retinal outer segment membrane protein 1
RUSC2 RUN and SH3 domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SCD5 stearoyl-CoA desaturase 5
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SKI SKI proto-oncogene
SLC12A8 solute carrier family 12, member 8
SP1 Sp1 transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SULT4A1 sulfotransferase family 4A, member 1
TARP TCR gamma alternate reading frame protein
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMEM51 transmembrane protein 51
TRAIP TRAF interacting protein
TSC22D4 TSC22 domain family, member 4
TSGA10 testis specific, 10
USB1 U6 snRNA biogenesis 1
WDR91 WD repeat domain 91
XK X-linked Kx blood group
ZNF16 zinc finger protein 16
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34
ZNF37BP zinc finger protein 37B, pseudogene
ZNF444 zinc finger protein 444
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747
ZSCAN26 zinc finger and SCAN domain containing 26