lactobionic acid-6605 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the lactobionic acid-6605 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
AFF1 AF4/FMR2 family, member 1
AKR1C2 aldo-keto reductase family 1, member C2
ANK2 ankyrin 2, neuronal
AREG amphiregulin
ARHGAP28 Rho GTPase activating protein 28
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATG10 autophagy related 10
C3ORF36 chromosome 3 open reading frame 36
CCDC30 coiled-coil domain containing 30
CCL27 chemokine (C-C motif) ligand 27
CD160 CD160 molecule
CDC14A cell division cycle 14A
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CLCN6 chloride channel, voltage-sensitive 6
CLTC clathrin, heavy chain (Hc)
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLC1 DLC1 Rho GTPase activating protein
DUOX1 dual oxidase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDNRA endothelin receptor type A
EFCAB11 EF-hand calcium binding domain 11
EPAS1 endothelial PAS domain protein 1
ESRRG estrogen-related receptor gamma
EYA3 EYA transcriptional coactivator and phosphatase 3
FKRP fukutin related protein
FLT1 fms-related tyrosine kinase 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GLRA2 glycine receptor, alpha 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPM6A glycoprotein M6A
GREM1 gremlin 1, DAN family BMP antagonist
GYPB glycophorin B (MNS blood group)
HES2 hes family bHLH transcription factor 2
HIST1H2BN histone cluster 1, H2bn
IGHA1 immunoglobulin heavy constant alpha 1
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
ING2 inhibitor of growth family, member 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIME1 Lck interacting transmembrane adaptor 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LTB4R leukotriene B4 receptor
MBD2 methyl-CpG binding domain protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MOBP myelin-associated oligodendrocyte basic protein
MPZ myelin protein zero
MYBPC3 myosin binding protein C, cardiac
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NEU3 sialidase 3 (membrane sialidase)
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRG1 neuregulin 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDPN podoplanin
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLXNB1 plexin B1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRDM2 PR domain containing 2, with ZNF domain
PRUNE2 prune homolog 2 (Drosophila)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RGCC regulator of cell cycle
RUNX1 runt-related transcription factor 1
SCN2B sodium channel, voltage gated, type II beta subunit
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SHH sonic hedgehog
SLC17A2 solute carrier family 17, member 2
SLC6A16 solute carrier family 6, member 16
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SNED1 sushi, nidogen and EGF-like domains 1
SPTB spectrin, beta, erythrocytic
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSX3 synovial sarcoma, X breakpoint 3
STMN3 stathmin-like 3
STS steroid sulfatase (microsomal), isozyme S
TACR1 tachykinin receptor 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D2 TBC1 domain family, member 2
THRA thyroid hormone receptor, alpha
TMEM53 transmembrane protein 53
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
UGT8 UDP glycosyltransferase 8
VCAN versican
XDH xanthine dehydrogenase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YIPF4 Yip1 domain family, member 4
YY2 YY2 transcription factor
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFAP1 actin filament associated protein 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ASAP1-IT1 ASAP1 intronic transcript 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C11ORF30 chromosome 11 open reading frame 30
C22ORF29 chromosome 22 open reading frame 29
C4ORF19 chromosome 4 open reading frame 19
CCDC68 coiled-coil domain containing 68
CD79B CD79b molecule, immunoglobulin-associated beta
CHM choroideremia (Rab escort protein 1)
CIR1 corepressor interacting with RBPJ, 1
CISH cytokine inducible SH2-containing protein
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COQ4 coenzyme Q4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST1 cystatin SN
DBF4B DBF4 zinc finger B
DNAH17 dynein, axonemal, heavy chain 17
DNMBP dynamin binding protein
DOLPP1 dolichyldiphosphatase 1
ERCC2 excision repair cross-complementation group 2
FANCC Fanconi anemia, complementation group C
FANCE Fanconi anemia, complementation group E
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR1 G protein-coupled receptor 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRAMD1C GRAM domain containing 1C
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIST1H2AK histone cluster 1, H2ak
HIST2H2AA3 histone cluster 2, H2aa3
HLX H2.0-like homeobox
HOXC8 homeobox C8
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFNA14 interferon, alpha 14
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL15RA interleukin 15 receptor, alpha
IL4R interleukin 4 receptor
IRF2BP1 interferon regulatory factor 2 binding protein 1
LMNB1 lamin B1
LMO7 LIM domain 7
LY96 lymphocyte antigen 96
LYRM9 LYR motif containing 9
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM4 MDM4, p53 regulator
MGC12488
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH1 notch 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAX9 paired box 9
PDE8B phosphodiesterase 8B
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNB3 plexin B3
POLM polymerase (DNA directed), mu
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRF1 perforin 1 (pore forming protein)
RPP25 ribonuclease P/MRP 25kDa subunit
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SIPA1 signal-induced proliferation-associated 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SRD5A3 steroid 5 alpha-reductase 3
STAC SH3 and cysteine rich domain
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
STK16 serine/threonine kinase 16
STK25 serine/threonine kinase 25
TAOK1 TAO kinase 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEAD3 TEA domain family member 3
TEX40 testis expressed 40
TOM1 target of myb1 (chicken)
TUBA4B tubulin, alpha 4b
ULBP2 UL16 binding protein 2
UNC93B1 unc-93 homolog B1 (C. elegans)
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
ZBTB39 zinc finger and BTB domain containing 39
ZFP30 ZFP30 zinc finger protein
ZNF253 zinc finger protein 253
ZNF549 zinc finger protein 549
ZNF675 zinc finger protein 675
ZNRD1-AS1 ZNRD1 antisense RNA 1