lacrimal apparatus disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

391 genes co-occuring with the disease lacrimal apparatus disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DCXR dicarbonyl/L-xylulose reductase 2.65239
LTF lactotransferrin 1.39214
HSPG2 heparan sulfate proteoglycan 2 1.32498
DNASE1L1 deoxyribonuclease I-like 1 1.3193
BPIFA2 BPI fold containing family A, member 2 1.3145
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 1.30969
PRR4 proline rich 4 (lacrimal) 1.29483
TNF tumor necrosis factor 1.26342
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.2495
LYZ lysozyme 1.24602
LCN1 lipocalin 1 1.21955
AQP5 aquaporin 5 1.18066
CD4 CD4 molecule 1.11015
LACRT lacritin 1.10973
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.05807
AATF apoptosis antagonizing transcription factor 1.04041
IL1B interleukin 1, beta 0.983057
S100A7 S100 calcium binding protein A7 0.958287
GJB6 gap junction protein, beta 6, 30kDa 0.916787
TLR4 toll-like receptor 4 0.881882
MUC4 mucin 4, cell surface associated 0.868368
MMP9 matrix metallopeptidase 9 0.851992
IL6 interleukin 6 0.836427
PRSS21 protease, serine, 21 (testisin) 0.799513
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.796642
IRAK4 interleukin-1 receptor-associated kinase 4 0.780251
MUC16 mucin 16, cell surface associated 0.773296
S100A9 S100 calcium binding protein A9 0.768393
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.766759
MUC7 mucin 7, secreted 0.762271
VSIG4 V-set and immunoglobulin domain containing 4 0.750864
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.745578
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.741517
PKD2L2 polycystic kidney disease 2-like 2 0.735838
SPRR1B small proline-rich protein 1B 0.732596
CD79A CD79a molecule, immunoglobulin-associated alpha 0.714811
MUC1 mucin 1, cell surface associated 0.71078
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.694702
ARSI arylsulfatase family, member I 0.692296
TGFB1 transforming growth factor, beta 1 0.683892
KLK13 kallikrein-related peptidase 13 0.683093
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.675112
ADSL adenylosuccinate lyase 0.673518
IL1A interleukin 1, alpha 0.67113
CCL2 chemokine (C-C motif) ligand 2 0.666755
S100A8 S100 calcium binding protein A8 0.664769
LYNX1 Ly6/neurotoxin 1 0.648928
IVL involucrin 0.648533
STAB1 stabilin 1 0.629242
SH2D1A SH2 domain containing 1A 0.629242
JAK2 Janus kinase 2 0.624535
HMGB1 high mobility group box 1 0.624535
FLG filaggrin 0.624143
CD40 CD40 molecule, TNF receptor superfamily member 5 0.616703
IFNA4 interferon, alpha 4 0.614747
TTR transthyretin 0.613965
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.608494
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.604591
PADI1 peptidyl arginine deiminase, type I 0.594454
PMVK phosphomevalonate kinase 0.590169
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 0.590169
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.588612
CADM1 cell adhesion molecule 1 0.574217
FASLG Fas ligand (TNF superfamily, member 6) 0.573439
CCL20 chemokine (C-C motif) ligand 20 0.57305
TFF3 trefoil factor 3 (intestinal) 0.570329
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.568775
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.5645
DNTT DNA nucleotidylexotransferase 0.559062
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.555568
ICAM1 intercellular adhesion molecule 1 0.552851
TRIM21 tripartite motif containing 21 0.550522
CXCR3 chemokine (C-X-C motif) receptor 3 0.548195
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 0.540829
RGPD1 RANBP2-like and GRIP domain containing 1 0.534635
HLA-C major histocompatibility complex, class I, C 0.531154
TLR5 toll-like receptor 5 0.528449
AGFG2 ArfGAP with FG repeats 2 0.523816
CXCL10 chemokine (C-X-C motif) ligand 10 0.521502
NBAS neuroblastoma amplified sequence 0.516879
TLR3 toll-like receptor 3 0.508041
SPRR1A small proline-rich protein 1A 0.50459
APOF apolipoprotein F 0.494648
MED4 mediator complex subunit 4 0.493503
ITSN2 intersectin 2 0.479047
FN1 fibronectin 1 0.475634
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.470711
SPRR2A small proline-rich protein 2A 0.470332
MYD88 myeloid differentiation primary response 88 0.467684
AOAH acyloxyacyl hydrolase (neutrophil) 0.466172
DGKQ diacylglycerol kinase, theta 110kDa 0.463905
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 0.461639
JUNB jun B proto-oncogene 0.458241
TLR2 toll-like receptor 2 0.456732
AQP3 aquaporin 3 (Gill blood group) 0.456355
MAPK8 mitogen-activated protein kinase 8 0.452208
PADI3 peptidyl arginine deiminase, type III 0.449571
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.448064
LOR loricrin 0.447687
MSR1 macrophage scavenger receptor 1 0.4443
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.441666
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.437154
EYA1 EYA transcriptional coactivator and phosphatase 1 0.436778
PHIP pleckstrin homology domain interacting protein 0.434899
IL1R1 interleukin 1 receptor, type I 0.434524
CD274 CD274 molecule 0.430017
EDA ectodysplasin A 0.429642
MMP21 matrix metallopeptidase 21 0.428516
RAB10 RAB10, member RAS oncogene family 0.42739
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.425514
LAX1 lymphocyte transmembrane adaptor 1 0.421016
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.418019
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.417644
KLF4 Kruppel-like factor 4 (gut) 0.416896
RANGAP1 Ran GTPase activating protein 1 0.411283
CCL4 chemokine (C-C motif) ligand 4 0.410909
TNPO3 transportin 3 0.406051
PSIP1 PC4 and SFRS1 interacting protein 1 0.405678
CD40LG CD40 ligand 0.401945
CXCL9 chemokine (C-X-C motif) ligand 9 0.399707
DSG3 desmoglein 3 0.398216
E2F7 E2F transcription factor 7 0.398216
RNASE7 ribonuclease, RNase A family, 7 0.39598
SASH1 SAM and SH3 domain containing 1 0.394491
LIPI lipase, member I 0.393001
MARVELD2 MARVEL domain containing 2 0.392629
CCL17 chemokine (C-C motif) ligand 17 0.387051
DEFA6 defensin, alpha 6, Paneth cell-specific 0.387051
CCL13 chemokine (C-C motif) ligand 13 0.384079
LDLR low density lipoprotein receptor 0.383708
ALB albumin 0.374068
SCARF1 scavenger receptor class F, member 1 0.373698
TADA3 transcriptional adaptor 3 0.372217
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.371107
MUC2 mucin 2, oligomeric mucus/gel-forming 0.36741
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.366671
IL17A interleukin 17A 0.363347
CA6 carbonic anhydrase VI 0.357814
RAB27B RAB27B, member RAS oncogene family 0.351923
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.351555
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.349349
NAT10 N-acetyltransferase 10 (GCN5-related) 0.348246
STAB2 stabilin 2 0.347511
CST4 cystatin S 0.345308
ILVBL ilvB (bacterial acetolactate synthase)-like 0.342372
SCARB2 scavenger receptor class B, member 2 0.340173
IL10 interleukin 10 0.337975
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.328469
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.328105
AREG amphiregulin 0.327375
CCR7 chemokine (C-C motif) receptor 7 0.32701
CD36 CD36 molecule (thrombospondin receptor) 0.325187
CD68 CD68 molecule 0.324823
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.317909
CCR6 chemokine (C-C motif) receptor 6 0.316092
AVIL advillin 0.313552
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 0.309566
PPAN-P2RY11 PPAN-P2RY11 readthrough 0.309566
MEGF6 multiple EGF-like-domains 6 0.309204
OCLN occludin 0.30631
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.305948
XCL1 chemokine (C motif) ligand 1 0.303059
TRIP12 thyroid hormone receptor interactor 12 0.301976
CTSZ cathepsin Z 0.295492
NGF nerve growth factor (beta polypeptide) 0.294413
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.292975
CD200 CD200 molecule 0.292257
MMP2 matrix metallopeptidase 2 0.289027
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.28831
SCARB1 scavenger receptor class B, member 1 0.285802
FAM83H family with sequence similarity 83, member H 0.285086
KRT10 keratin 10, type I 0.282582
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.27794
SOD2 superoxide dismutase 2, mitochondrial 0.274376
FKBP2 FK506 binding protein 2, 13kDa 0.274021
MAPK14 mitogen-activated protein kinase 14 0.272597
KRT1 keratin 1, type II 0.272241
AIRE autoimmune regulator 0.268687
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.267622
MMP1 matrix metallopeptidase 1 0.263014
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.263014
JUN jun proto-oncogene 0.262306
XDH xanthine dehydrogenase 0.259477
NELFCD negative elongation factor complex member C/D 0.25877
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.257005
XCR1 chemokine (C motif) receptor 1 0.257005
FFAR4 free fatty acid receptor 4 0.251366
TBX21 T-box 21 0.251015
FOXP3 forkhead box P3 0.249608
DKK4 dickkopf WNT signaling pathway inhibitor 4 0.249257
KDM6B lysine (K)-specific demethylase 6B 0.248554
CCL7 chemokine (C-C motif) ligand 7 0.245396
PRG4 proteoglycan 4 0.244345
TGM3 transglutaminase 3 0.243295
TANK TRAF family member-associated NFKB activator 0.242245
MMP13 matrix metallopeptidase 13 0.240497
FAM167A family with sequence similarity 167, member A 0.240148
TLR9 toll-like receptor 9 0.23945
VIL1 villin 1 0.237009
RPLP0 ribosomal protein, large, P0 0.236312
IL1RN interleukin 1 receptor antagonist 0.235616
RREB1 ras responsive element binding protein 1 0.233183
RANBP2 RAN binding protein 2 0.232836
TOLLIP toll interacting protein 0.220081
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.219398
SCGB1D1 secretoglobin, family 1D, member 1 0.219057
ARG1 arginase 1 0.216332
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.213959
SCGB2A1 secretoglobin, family 2A, member 1 0.210253
DEFA5 defensin, alpha 5, Paneth cell-specific 0.207578
IL17C interleukin 17C 0.206913
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.204593
TWIST2 twist family bHLH transcription factor 2 0.200982
HDAC11 histone deacetylase 11 0.200982
GLDC glycine dehydrogenase (decarboxylating) 0.200982
TF transferrin 0.199681
E2F6 E2F transcription factor 6 0.198064
ICAM3 intercellular adhesion molecule 3 0.19582
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.194548
ICA1 islet cell autoantigen 1, 69kDa 0.194548
KRT12 keratin 12, type I 0.193915
ADSS adenylosuccinate synthase 0.193915
MAPK9 mitogen-activated protein kinase 9 0.193285
EXT1 exostosin glycosyltransferase 1 0.192657
KRT14 keratin 14, type I 0.191097
TLR1 toll-like receptor 1 0.190786
UCN urocortin 0.190476
FRMD6 FERM domain containing 6 0.190476
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.189244
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.188938
PIP prolactin-induced protein 0.188326
CCL3 chemokine (C-C motif) ligand 3 0.187113
CTSS cathepsin S 0.18591
TSPO translocator protein (18kDa) 0.183835
ADCY9 adenylate cyclase 9 0.183248
IRF5 interferon regulatory factor 5 0.182666
TLR7 toll-like receptor 7 0.182086
FABP7 fatty acid binding protein 7, brain 0.181222
CLCN2 chloride channel, voltage-sensitive 2 0.180367
GAS1 growth arrest-specific 1 0.17952
MPO myeloperoxidase 0.177029
PRF1 perforin 1 (pore forming protein) 0.176485
CXCR5 chemokine (C-X-C motif) receptor 5 0.176215
SLURP1 secreted LY6/PLAUR domain containing 1 0.175146
IGF1 insulin-like growth factor 1 (somatomedin C) 0.175146
PKD2L1 polycystic kidney disease 2-like 1 0.174093
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.173057
CPVL carboxypeptidase, vitellogenic-like 0.172799
CD209 CD209 molecule 0.172544
CXCL11 chemokine (C-X-C motif) ligand 11 0.172544
CORO1A coronin, actin binding protein, 1A 0.172038
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.172038
NPR1 natriuretic peptide receptor 1 0.170544
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.170299
ZMYND10 zinc finger, MYND-type containing 10 0.170299
GUCY2C guanylate cyclase 2C 0.170054
SHB Src homology 2 domain containing adaptor protein B 0.168148
PNMA1 paraneoplastic Ma antigen 1 0.165874
TP63 tumor protein p63 0.164571
CARD8 caspase recruitment domain family, member 8 0.164571
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.164149
THY1 Thy-1 cell surface antigen 0.163938
CCL5 chemokine (C-C motif) ligand 5 0.161912
SFTPD surfactant protein D 0.161716
IRF3 interferon regulatory factor 3 0.161716
TIMP1 TIMP metallopeptidase inhibitor 1 0.161331
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.160761
PDCD1LG2 programmed cell death 1 ligand 2 0.160387
IRAK3 interleukin-1 receptor-associated kinase 3 0.160203
DCT dopachrome tautomerase 0.142903
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.141464
FLNA filamin A, alpha 0.135269
MAEA macrophage erythroblast attacher 0.132735
IL21 interleukin 21 0.132335
AZU1 azurocidin 1 0.130251
DEFB4A defensin, beta 4A 0.129167
DEFB1 defensin, beta 1 0.128903
SIX5 SIX homeobox 5 0.125776
PTPRJ protein tyrosine phosphatase, receptor type, J 0.125462
SIX1 SIX homeobox 1 0.123702
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.123506
BPI bactericidal/permeability-increasing protein 0.121863
IGLV2-14 immunoglobulin lambda variable 2-14 0.121587
CRP C-reactive protein, pentraxin-related 0.119186
MUT methylmalonyl CoA mutase 0.118343
CLU clusterin 0.117716
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.114447
HES5 hes family bHLH transcription factor 5 0.112337
PTGDR2 prostaglandin D2 receptor 2 0.112126
IGHV4-39 immunoglobulin heavy variable 4-39 0.111154
CLDN1 claudin 1 0.111081
TADA1 transcriptional adaptor 1 0.110058
SOCS3 suppressor of cytokine signaling 3 0.11002
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.109886
CLDN7 claudin 7 0.109694
ACE2 angiotensin I converting enzyme 2 0.108609
RHO rhodopsin 0.108491
TBX2 T-box 2 0.106382
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.106258
PIGR polymeric immunoglobulin receptor 0.106216
RBP1 retinol binding protein 1, cellular 0.106029
MMP8 matrix metallopeptidase 8 0.105904
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.10552
RNASEH2A ribonuclease H2, subunit A 0.105264
SSB Sjogren syndrome antigen B (autoantigen La) 0.104533
CRYZ crystallin, zeta (quinone reductase) 0.104445
SIGLEC10 sialic acid binding Ig-like lectin 10 0.103964
CENPB centromere protein B, 80kDa 0.103723
IGHV5-51 immunoglobulin heavy variable 5-51 0.103478
AICDA activation-induced cytidine deaminase 0.103186
CHRM3 cholinergic receptor, muscarinic 3 0.10276
PRRC2A proline-rich coiled-coil 2A 0.102581
SIX3 SIX homeobox 3 0.1024
SOCS2 suppressor of cytokine signaling 2 0.101871
PRDX6 peroxiredoxin 6 0.101664
TXNL4B thioredoxin-like 4B 0.10132
CAMP cathelicidin antimicrobial peptide 0.101133
NMT1 N-myristoyltransferase 1 0.100851
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.099594
S100A6 S100 calcium binding protein A6 0.099281
BMP6 bone morphogenetic protein 6 0.099185
SP6 Sp6 transcription factor 0.095858
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.094781
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.094441
AQP4 aquaporin 4 0.094049
HAND1 heart and neural crest derivatives expressed 1 0.093945
TOP3A topoisomerase (DNA) III alpha 0.092968
GATA3 GATA binding protein 3 0.092009
RAG1 recombination activating gene 1 0.090433
HLA-DMA major histocompatibility complex, class II, DM alpha 0.089964
CD80 CD80 molecule 0.089716
GGT1 gamma-glutamyltransferase 1 0.089661
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.087565
FTH1 ferritin, heavy polypeptide 1 0.087138
FTL ferritin, light polypeptide 0.087138
JAK3 Janus kinase 3 0.085737
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.08516
KITLG KIT ligand 0.084959
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.084786
BCL6 B-cell CLL/lymphoma 6 0.082526
TG thyroglobulin 0.082467
LRP5 low density lipoprotein receptor-related protein 5 0.080919
KMT2A lysine (K)-specific methyltransferase 2A 0.080919
VCAM1 vascular cell adhesion molecule 1 0.076457
AARS alanyl-tRNA synthetase 0.076396
SALL1 spalt-like transcription factor 1 0.075841
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.075811
IFNL1 interferon, lambda 1 0.075718
ANG angiogenin, ribonuclease, RNase A family, 5 0.075657
CCL22 chemokine (C-C motif) ligand 22 0.075534
GLB1 galactosidase, beta 1 0.075472
BCAN brevican 0.075256
PTPRC protein tyrosine phosphatase, receptor type, C 0.075132
LY75 lymphocyte antigen 75 0.074666
FADD Fas (TNFRSF6)-associated via death domain 0.074449
PLK2 polo-like kinase 2 0.074449
APOLD1 apolipoprotein L domain containing 1 0.0742
TSLP thymic stromal lymphopoietin 0.074014
NPTXR neuronal pentraxin receptor 0.073983
C3AR1 complement component 3a receptor 1 0.073579
KRT5 keratin 5, type II 0.072954
IQGAP1 IQ motif containing GTPase activating protein 1 0.072798
TNIP1 TNFAIP3 interacting protein 1 0.072704
PRKD1 protein kinase D1 0.072673
CCL27 chemokine (C-C motif) ligand 27 0.072673
MIRLET7B microRNA let-7b 0.072143
GLUL glutamate-ammonia ligase 0.072111
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.072111
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.071954
TAC1 tachykinin, precursor 1 0.071923
CTGF connective tissue growth factor 0.071891
C3 complement component 3 0.071703
CRHR2 corticotropin releasing hormone receptor 2 0.071388
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.071357
PNP purine nucleoside phosphorylase 0.071294
MT3 metallothionein 3 0.071074
BAX BCL2-associated X protein 0.071012
IGFBP7 insulin-like growth factor binding protein 7 0.071012
MRI1 methylthioribose-1-phosphate isomerase 1 0.07098
GPBAR1 G protein-coupled bile acid receptor 1 0.07098
POU5F1B POU class 5 homeobox 1B 0.070855
RAB3D RAB3D, member RAS oncogene family 0.070698
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.070478
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.070415
CCNB1 cyclin B1 0.07032
NRTN neurturin 0.070226
KRT15 keratin 15, type I 0.070226
SCAI suppressor of cancer cell invasion 0.070194
LGALS9 lectin, galactoside-binding, soluble, 9 0.070194
BOC BOC cell adhesion associated, oncogene regulated 0.070036
HBEGF heparin-binding EGF-like growth factor 0.069973