kidney failure Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. (Human Disease Ontology, DOID_1074)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:1074
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Genes

276 genes associated with the disease kidney failure in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
OSBPL1A oxysterol binding protein-like 1A 1.34818
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 1.31709
SHROOM3 shroom family member 3 1.31088
ADCY5 adenylate cyclase 5 1.25589
HMGA2 high mobility group AT-hook 2 1.24634
DTWD2 DTW domain containing 2 1.23249
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.17795
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 1.10395
GAREM GRB2 associated, regulator of MAPK1 1.10318
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.958374
ALMS1P Alstrom syndrome 1 pseudogene 0.958374
BCAS3 breast carcinoma amplified sequence 3 0.958374
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 0.917276
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 0.871531
GCKR glucokinase (hexokinase 4) regulator 0.826983
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.805161
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.784143
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.727555
WDR72 WD repeat domain 72 0.722796
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.697114
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 0.621333
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.583815
DACH1 dachshund family transcription factor 1 0.583815
ATXN2 ataxin 2 0.576592
GRIP1 glutamate receptor interacting protein 1 0.574628
MAP3K15 mitogen-activated protein kinase kinase kinase 15 0.572704
LCORL ligand dependent nuclear receptor corepressor-like 0.570922
CEP89 centrosomal protein 89kDa 0.570922
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.564311
GRM1 glutamate receptor, metabotropic 1 0.547225
PTPRE protein tyrosine phosphatase, receptor type, E 0.547225
SMYD3 SET and MYND domain containing 3 0.536492
TBX2 T-box 2 0.523865
UMOD uromodulin 0.516381
MYH9 myosin, heavy chain 9, non-muscle 0.511865
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 0.496271
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.493349
CDK12 cyclin-dependent kinase 12 0.484181
ADRB1 adrenoceptor beta 1 0.482571
PHACTR1 phosphatase and actin regulator 1 0.478722
WDR37 WD repeat domain 37 0.477278
RNF185 ring finger protein 185 0.471463
FRMD4A FERM domain containing 4A 0.471322
LIMK2 LIM domain kinase 2 0.470155
ALMS1 Alstrom syndrome protein 1 0.469658
INO80 INO80 complex subunit 0.468295
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 0.466639
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.459663
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.459061
PDE4D phosphodiesterase 4D, cAMP-specific 0.458904
LARGE like-glycosyltransferase 0.456271
SGK1 serum/glucocorticoid regulated kinase 1 0.453673
HSDL2 hydroxysteroid dehydrogenase like 2 0.446778
DOK6 docking protein 6 0.445948
PDZRN3 PDZ domain containing ring finger 3 0.444585
CHN2 chimerin 2 0.443666
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.442803
FBXL20 F-box and leucine-rich repeat protein 20 0.440638
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.437349
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.433661
KIRREL3 kin of IRRE like 3 (Drosophila) 0.432907
GRIK2 glutamate receptor, ionotropic, kainate 2 0.432762
PVT1 Pvt1 oncogene (non-protein coding) 0.430311
GAS2 growth arrest-specific 2 0.430311
ZBTB20 zinc finger and BTB domain containing 20 0.42969
KIAA1958 KIAA1958 0.425751
CENPM centromere protein M 0.425585
CARS cysteinyl-tRNA synthetase 0.425341
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.42331
STEAP1B STEAP family member 1B 0.422054
PTPRM protein tyrosine phosphatase, receptor type, M 0.422054
SPATS2L spermatogenesis associated, serine-rich 2-like 0.421782
SORBS1 sorbin and SH3 domain containing 1 0.420617
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.419335
PCSK2 proprotein convertase subtilisin/kexin type 2 0.419335
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.419335
NRG1 neuregulin 1 0.414949
ELMO1 engulfment and cell motility 1 0.413127
PRR5L proline rich 5 like 0.41311
SH3BP4 SH3-domain binding protein 4 0.411526
TENM4 teneurin transmembrane protein 4 0.410651
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.409312
UNC5C unc-5 homolog C (C. elegans) 0.40869
CDC6 cell division cycle 6 0.408213
NTNG2 netrin G2 0.406589
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.404761
C6ORF10 chromosome 6 open reading frame 10 0.404129
WDR20 WD repeat domain 20 0.403132
LOC100132891 0.403132
LOC100294145 uncharacterized LOC100294145 0.403132
TBC1D22A TBC1 domain family, member 22A 0.400815
TBC1D14 TBC1 domain family, member 14 0.400248
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.399626
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.398956
PDE5A phosphodiesterase 5A, cGMP-specific 0.398956
MXRA7 matrix-remodelling associated 7 0.398385
GRM4 glutamate receptor, metabotropic 4 0.397971
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.397436
PRRC2A proline-rich coiled-coil 2A 0.396908
FAM134B family with sequence similarity 134, member B 0.39618
SMYD2 SET and MYND domain containing 2 0.394164
KAZN kazrin, periplakin interacting protein 0.392306
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.391259
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.390324
NCALD neurocalcin delta 0.387883
MARCH11 membrane-associated ring finger (C3HC4) 11 0.387883
MACF1 microtubule-actin crosslinking factor 1 0.387155
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.38703
CNTN1 contactin 1 0.386824
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.386579
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.386458
ILDR1 immunoglobulin-like domain containing receptor 1 0.386219
COL11A2 collagen, type XI, alpha 2 0.38614
FAM189A1 family with sequence similarity 189, member A1 0.385483
ISM1 isthmin 1, angiogenesis inhibitor 0.385446
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.385146
IL12RB1 interleukin 12 receptor, beta 1 0.385109
DNAH11 dynein, axonemal, heavy chain 11 0.385072
TBC1D31 TBC1 domain family, member 31 0.384888
MSRA methionine sulfoxide reductase A 0.384888
NTN1 netrin 1 0.384175
MRPL48 mitochondrial ribosomal protein L48 0.382855
FGF12 fibroblast growth factor 12 0.382566
MTUS1 microtubule associated tumor suppressor 1 0.382352
OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.382001
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.381932
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.381759
SYT1 synaptotagmin I 0.38142
NTM neurotrimin 0.381086
BEND5 BEN domain containing 5 0.381086
MYO5B myosin VB 0.380214
STK3 serine/threonine kinase 3 0.379232
TMEM63C transmembrane protein 63C 0.379203
NRXN1 neurexin 1 0.379143
SCOC short coiled-coil protein 0.378907
SH2D4A SH2 domain containing 4A 0.378877
LOC645513 uncharacterized LOC645513 0.378615
RXRB retinoid X receptor, beta 0.377824
RNF17 ring finger protein 17 0.377769
ZNF202 zinc finger protein 202 0.377769
FOXO3 forkhead box O3 0.377306
GAP43 growth associated protein 43 0.377225
LOC284661 uncharacterized LOC284661 0.37696
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.376802
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.376261
NRXN3 neurexin 3 0.37616
NEGR1 neuronal growth regulator 1 0.375884
ELAVL4 ELAV like neuron-specific RNA binding protein 4 0.375686
ESRRG estrogen-related receptor gamma 0.375588
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.375201
FABP2 fatty acid binding protein 2, intestinal 0.374963
ZMIZ1 zinc finger, MIZ-type containing 1 0.374728
CA10 carbonic anhydrase X 0.373863
NBN nibrin 0.37384
KIAA1549L KIAA1549-like 0.37384
UBE2J1 ubiquitin-conjugating enzyme E2, J1 0.373598
DNAH5 dynein, axonemal, heavy chain 5 0.373337
IL21R interleukin 21 receptor 0.373272
GOLGA1 golgin A1 0.373207
GRID2 glutamate receptor, ionotropic, delta 2 0.372931
IPO11 importin 11 0.372889
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.372889
SH3GL2 SH3-domain GRB2-like 2 0.372328
PEX7 peroxisomal biogenesis factor 7 0.372328
SAR1A secretion associated, Ras related GTPase 1A 0.372328
TNRC6B trinucleotide repeat containing 6B 0.372247
PCDH9 protocadherin 9 0.372206
FAM217A family with sequence similarity 217, member A 0.371904
CERS6 ceramide synthase 6 0.371529
VWDE von Willebrand factor D and EGF domains 0.371432
OPCML opioid binding protein/cell adhesion molecule-like 0.371354
ADD1 adducin 1 (alpha) 0.3712
ISG20 interferon stimulated exonuclease gene 20kDa 0.371085
SIK3 SIK family kinase 3 0.370556
CTIF CBP80/20-dependent translation initiation factor 0.370362
CADM4 cell adhesion molecule 4 0.36998
LOC63930 uncharacterized LOC63930 0.36942
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.369237
ZNF714 zinc finger protein 714 0.369056
ACSS3 acyl-CoA synthetase short-chain family member 3 0.368523
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.368523
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.3675
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.367172
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.367009
MACROD2 MACRO domain containing 2 0.367009
KRT35 keratin 35, type I 0.366848
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.366689
KRT2 keratin 2, type II 0.366531
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.365311
ALPK1 alpha-kinase 1 0.364167
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.364028
CFAP61 cilia and flagella associated protein 61 0.363891
SDK1 sidekick cell adhesion molecule 1 0.363891
SH2D4B SH2 domain containing 4B 0.363755
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.362572
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.362572
CDH8 cadherin 8, type 2 0.362445
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.362319
NEB nebulin 0.36087
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.36087
CDH13 cadherin 13 0.360525
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.360411
GRAMD3 GRAM domain containing 3 0.359206
EPB41 erythrocyte membrane protein band 4.1 0.3591
RGS6 regulator of G-protein signaling 6 0.358683
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.358683
LRP1B low density lipoprotein receptor-related protein 1B 0.357876
TLE3 transducin-like enhancer of split 3 0.357293
BID BH3 interacting domain death agonist 0.357293
MUC4 mucin 4, cell surface associated 0.357198
RAI14 retinoic acid induced 14 0.357092
NELL1 NEL-like 1 (chicken) 0.356986
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.356777
ZNF697 zinc finger protein 697 0.356365
EYA1 EYA transcriptional coactivator and phosphatase 1 0.356263
CRBN cereblon 0.355466
KRT33B keratin 33B, type I 0.3547
CTNND2 catenin (cadherin-associated protein), delta 2 0.35442
FMN2 formin 2 0.353962
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.353513
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.353337
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.353249
AGBL1 ATP/GTP binding protein-like 1 0.353249
MMS22L MMS22-like, DNA repair protein 0.353162
SIDT2 SID1 transmembrane family, member 2 0.353162
MGC27382 uncharacterized MGC27382 0.352988
KRTAP16-1 keratin associated protein 16-1 0.352646
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.351652
RABGAP1L RAB GTPase activating protein 1-like 0.35149
WDR1 WD repeat domain 1 0.351331
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.350937
PLCD3 phospholipase C, delta 3 0.350551
SCG3 secretogranin III 0.350097
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.350097
DNAH12 dynein, axonemal, heavy chain 12 0.349726
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene 0.349653
RRBP1 ribosome binding protein 1 0.349507
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.348723
WWOX WW domain containing oxidoreductase 0.348377
EXOSC3 exosome component 3 0.348308
PARD6B par-6 family cell polarity regulator beta 0.348308
SV2C synaptic vesicle glycoprotein 2C 0.348037
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.347835
ANK2 ankyrin 2, neuronal 0.347243
WDR17 WD repeat domain 17 0.347243
ACOX3 acyl-CoA oxidase 3, pristanoyl 0.347113
UNC13C unc-13 homolog C (C. elegans) 0.347113
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.346985
C3ORF67 chromosome 3 open reading frame 67 0.346479
PQBP1 polyglutamine binding protein 1 0.345268
FAM107B family with sequence similarity 107, member B 0.344519
PTN pleiotrophin 0.344463
ADD3 adducin 3 (gamma) 0.344406
YPEL1 yippee-like 1 (Drosophila) 0.34435
F9 coagulation factor IX 0.344183
FHOD3 formin homology 2 domain containing 3 0.342788
BAG1 BCL2-associated athanogene 0.342428
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.342428
THBS4 thrombospondin 4 0.338905
TELO2 telomere maintenance 2 0.337461
TMPO thymopoietin 0.337413
BMPR1B bone morphogenetic protein receptor, type IB 0.33647
ZNF180 zinc finger protein 180 0.332967
ITGA1 integrin, alpha 1 0.331885
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 0.331511
VWF von Willebrand factor 0.327449
SGK223 homolog of rat pragma of Rnd2 0.325193
C4ORF33 chromosome 4 open reading frame 33 0.3249
ALS2CL ALS2 C-terminal like 0.323978
COL5A1 collagen, type V, alpha 1 0.323484
COL4A1 collagen, type IV, alpha 1 0.323484
PRUNE prune exopolyphosphatase 0.323179
GRHL2 grainyhead-like 2 (Drosophila) 0.323179
NRG4 neuregulin 4 0.323179
BMP5 bone morphogenetic protein 5 0.321709
CHD9 chromodomain helicase DNA binding protein 9 0.321284