ketotifen-7199 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ketotifen-7199 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACSL4 acyl-CoA synthetase long-chain family member 4
AHCYL2 adenosylhomocysteinase-like 2
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
C10ORF88 chromosome 10 open reading frame 88
C19ORF73 chromosome 19 open reading frame 73
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCNO cyclin O
CDC14A cell division cycle 14A
CEP290 centrosomal protein 290kDa
CLASP2 cytoplasmic linker associated protein 2
CLDN1 claudin 1
COPA coatomer protein complex, subunit alpha
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPD carboxypeptidase D
CPQ carboxypeptidase Q
CTNND2 catenin (cadherin-associated protein), delta 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DICER1 dicer 1, ribonuclease type III
DVL2 dishevelled segment polarity protein 2
EBF2 early B-cell factor 2
EDNRA endothelin receptor type A
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
F8 coagulation factor VIII, procoagulant component
FAM169A family with sequence similarity 169, member A
FAS Fas cell surface death receptor
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPC4 glypican 4
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPS1 Hermansky-Pudlak syndrome 1
ISG20 interferon stimulated exonuclease gene 20kDa
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA0485 uncharacterized LOC57235
KIAA0930 KIAA0930
LIMK1 LIM domain kinase 1
LRRC61 leucine rich repeat containing 61
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NDE1 nudE neurodevelopment protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NIPAL2 NIPA-like domain containing 2
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARD6A par-6 family cell polarity regulator alpha
PDE4DIP phosphodiesterase 4D interacting protein
PEX11A peroxisomal biogenesis factor 11 alpha
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIBF1 progesterone immunomodulatory binding factor 1
PKNOX1 PBX/knotted 1 homeobox 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PRPH peripherin
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTBP3 polypyrimidine tract binding protein 3
QKI QKI, KH domain containing, RNA binding
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP9 retinoblastoma binding protein 9
RBL1 retinoblastoma-like 1
RCAN1 regulator of calcineurin 1
RHOQ ras homolog family member Q
RNASEH2B ribonuclease H2, subunit B
RNF6 ring finger protein (C3H2C3 type) 6
SDC2 syndecan 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFXN3 sideroflexin 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOD2 superoxide dismutase 2, mitochondrial
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D17 TBC1 domain family, member 17
TEP1 telomerase-associated protein 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB2 transforming growth factor, beta 2
THBD thrombomodulin
THOC5 THO complex 5
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
VDAC3 voltage-dependent anion channel 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHD1 bromo adjacent homology domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BICD1 bicaudal D homolog 1 (Drosophila)
C11ORF80 chromosome 11 open reading frame 80
C7ORF43 chromosome 7 open reading frame 43
CASD1 CAS1 domain containing 1
CDADC1 cytidine and dCMP deaminase domain containing 1
CEP131 centrosomal protein 131kDa
COL9A2 collagen, type IX, alpha 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DSPP dentin sialophosphoprotein
EPHA2 EPH receptor A2
FGF23 fibroblast growth factor 23
FGGY FGGY carbohydrate kinase domain containing
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAN gigaxonin
GPX2 glutathione peroxidase 2
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HPS6 Hermansky-Pudlak syndrome 6
IDI2-AS1 IDI2 antisense RNA 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRX4 iroquois homeobox 4
KIF16B kinesin family member 16B
KREMEN2 kringle containing transmembrane protein 2
KRT31 keratin 31, type I
LAMA3 laminin, alpha 3
LOC390998 ribosomal protein L10 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC37A2 leucine rich repeat containing 37, member A2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1S microtubule-associated protein 1S
MED15 mediator complex subunit 15
MED9 mediator complex subunit 9
MEIS1 Meis homeobox 1
MITF microphthalmia-associated transcription factor
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NOTCH1 notch 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUP62CL nucleoporin 62kDa C-terminal like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
ORAI3 ORAI calcium release-activated calcium modulator 3
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCAN3 RCAN family member 3
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
SAV1 salvador family WW domain containing protein 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCAMP5 secretory carrier membrane protein 5
SETD1A SET domain containing 1A
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNX15 sorting nexin 15
SOWAHC sosondowah ankyrin repeat domain family member C
SOX12 SRY (sex determining region Y)-box 12
SPATA7 spermatogenesis associated 7
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SREK1IP1 SREK1-interacting protein 1
STRN striatin, calmodulin binding protein
TCTA T-cell leukemia translocation altered
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TLN1 talin 1
TMEM104 transmembrane protein 104
TNS2 tensin 2
TPST1 tyrosylprotein sulfotransferase 1
TRAPPC12 trafficking protein particle complex 12
TRIM5 tripartite motif containing 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
UNKL unkempt family zinc finger-like
VPS9D1 VPS9 domain containing 1
VWA1 von Willebrand factor A domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMAT5 zinc finger, matrin-type 5
ZNF318 zinc finger protein 318
ZNF586 zinc finger protein 586