ketorolac-3110 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ketorolac-3110 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM1 acyl-CoA synthetase medium-chain family member 1
ADCY6 adenylate cyclase 6
AFF4 AF4/FMR2 family, member 4
AJAP1 adherens junctions associated protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGAP35 Rho GTPase activating protein 35
BLZF1 basic leucine zipper nuclear factor 1
BMP1 bone morphogenetic protein 1
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
C7ORF69 chromosome 7 open reading frame 69
CCDC33 coiled-coil domain containing 33
CD47 CD47 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH10 cadherin 10, type 2 (T2-cadherin)
CDON cell adhesion associated, oncogene regulated
CDRT1 CMT1A duplicated region transcript 1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COPE coatomer protein complex, subunit epsilon
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRABP2 cellular retinoic acid binding protein 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCAF15 DDB1 and CUL4 associated factor 15
DMP1 dentin matrix acidic phosphoprotein 1
DSTYK dual serine/threonine and tyrosine protein kinase
E2F5 E2F transcription factor 5, p130-binding
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EML2 echinoderm microtubule associated protein like 2
ENG endoglin
ESR2 estrogen receptor 2 (ER beta)
FAM120C family with sequence similarity 120C
FAM76A family with sequence similarity 76, member A
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS6 growth arrest-specific 6
GPC1 glypican 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GSPT1 G1 to S phase transition 1
HBB hemoglobin, beta
HIST1H4A histone cluster 1, H4a
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXB6 homeobox B6
IFNA16 interferon, alpha 16
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
LRRN3 leucine rich repeat neuronal 3
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MPDZ multiple PDZ domain protein
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MSR1 macrophage scavenger receptor 1
MYO15B myosin XVB
NNAT neuronatin
NOX1 NADPH oxidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NTN3 netrin 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALLD palladin, cytoskeletal associated protein
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PML promyelocytic leukemia
PODXL2 podocalyxin-like 2
PRKCE protein kinase C, epsilon
PROL1 proline rich, lacrimal 1
PRR7 proline rich 7 (synaptic)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS14 regulator of G-protein signaling 14
RIF1 replication timing regulatory factor 1
RYR1 ryanodine receptor 1 (skeletal)
SERHL2 serine hydrolase-like 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPTB spectrin, beta, erythrocytic
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TAPT1 transmembrane anterior posterior transformation 1
TBX5 T-box 5
TBXA2R thromboxane A2 receptor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TPMT thiopurine S-methyltransferase
TSSK2 testis-specific serine kinase 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
XCL1 chemokine (C motif) ligand 1
ZC3H7B zinc finger CCCH-type containing 7B
ZFYVE9 zinc finger, FYVE domain containing 9
ZIC3 Zic family member 3
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARHGAP11A Rho GTPase activating protein 11A
ATG9A autophagy related 9A
B3GNT1
C11ORF68 chromosome 11 open reading frame 68
C17ORF80 chromosome 17 open reading frame 80
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN15 calpain 15
CD180 CD180 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHMP7 charged multivesicular body protein 7
CISH cytokine inducible SH2-containing protein
CLDN7 claudin 7
CLEC2D C-type lectin domain family 2, member D
DENND1A DENN/MADD domain containing 1A
DFNA5 deafness, autosomal dominant 5
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAL4 dynein, axonemal, light chain 4
DUSP8 dual specificity phosphatase 8
DVL1 dishevelled segment polarity protein 1
ELP6 elongator acetyltransferase complex subunit 6
ENAH enabled homolog (Drosophila)
FAM50B family with sequence similarity 50, member B
FGF22 fibroblast growth factor 22
FGF9 fibroblast growth factor 9
FOXO4 forkhead box O4
FPGS folylpolyglutamate synthase
GLRA1 glycine receptor, alpha 1
GMDS GDP-mannose 4,6-dehydratase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIST1H2BG histone cluster 1, H2bg
HIST1H3G histone cluster 1, H3g
IDI2-AS1 IDI2 antisense RNA 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-44 immunoglobulin lambda variable 1-44
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
JUNB jun B proto-oncogene
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA0753 KIAA0753
KIFC1 kinesin family member C1
KLF13 Kruppel-like factor 13
LDB1 LIM domain binding 1
LIN37 lin-37 DREAM MuvB core complex component
LMBR1L limb development membrane protein 1-like
LOC100286895 cell division cycle 27 homolog pseudogene
LRP6 low density lipoprotein receptor-related protein 6
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MCPH1 microcephalin 1
MOCS3 molybdenum cofactor synthesis 3
MTCP1 mature T-cell proliferation 1
MX1 MX dynamin-like GTPase 1
MYBPH myosin binding protein H
NIPAL2 NIPA-like domain containing 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOL10 nucleolar protein 10
NXPH4 neurexophilin 4
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDGFRL platelet-derived growth factor receptor-like
PECR peroxisomal trans-2-enoyl-CoA reductase
PIAS3 protein inhibitor of activated STAT, 3
PIR pirin (iron-binding nuclear protein)
PLA2G12A phospholipase A2, group XIIA
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRDM1 PR domain containing 1, with ZNF domain
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STEAP3 STEAP family member 3, metalloreductase
TIGD6 tigger transposable element derived 6
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM115 transmembrane protein 115
TMEM180 transmembrane protein 180
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBQLN4 ubiquilin 4
VSIG10 V-set and immunoglobulin domain containing 10
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF250 zinc finger protein 250
ZNF32 zinc finger protein 32
ZNF528 zinc finger protein 528
ZNF747 zinc finger protein 747
ZNF787 zinc finger protein 787