ketoprofen-4286 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ketoprofen-4286 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
AGXT alanine-glyoxylate aminotransferase
AKAP5 A kinase (PRKA) anchor protein 5
AMPD3 adenosine monophosphate deaminase 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARNT aryl hydrocarbon receptor nuclear translocator
ATP11A ATPase, class VI, type 11A
C22ORF46 chromosome 22 open reading frame 46
CBS cystathionine-beta-synthase
CD6 CD6 molecule
CD86 CD86 molecule
CEP250 centrosomal protein 250kDa
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIC capicua transcriptional repressor
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLDN17 claudin 17
CLDN8 claudin 8
COMT catechol-O-methyltransferase
CSF1 colony stimulating factor 1 (macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTSG cathepsin G
CYP2A7P1 cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DST dystonin
EFNB3 ephrin-B3
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR2 estrogen receptor 2 (ER beta)
ESRRG estrogen-related receptor gamma
FAM49B family with sequence similarity 49, member B
FBXL18 F-box and leucine-rich repeat protein 18
FBXO4 F-box protein 4
FGF16 fibroblast growth factor 16
FGF18 fibroblast growth factor 18
GNRH2 gonadotropin-releasing hormone 2
GPNMB glycoprotein (transmembrane) nmb
GPR17 G protein-coupled receptor 17
GREB1L growth regulation by estrogen in breast cancer-like
GRIP2 glutamate receptor interacting protein 2
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
ICOS inducible T-cell co-stimulator
INE1 inactivation escape 1 (non-protein coding)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0485 uncharacterized LOC57235
LDB2 LIM domain binding 2
LOC100287387 uncharacterized LOC100287387
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MED25 mediator complex subunit 25
METTL7A methyltransferase like 7A
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MOBP myelin-associated oligodendrocyte basic protein
MSR1 macrophage scavenger receptor 1
MUC8 mucin 8
N4BP2L1 NEDD4 binding protein 2-like 1
NCR2 natural cytotoxicity triggering receptor 2
NEK9 NIMA-related kinase 9
NFASC neurofascin
NOD2 nucleotide-binding oligomerization domain containing 2
NYNRIN NYN domain and retroviral integrase containing
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OSBPL7 oxysterol binding protein-like 7
PKP3 plakophilin 3
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK3 polo-like kinase 3
PRAF2 PRA1 domain family, member 2
PRODH2 proline dehydrogenase (oxidase) 2
PVT1 Pvt1 oncogene (non-protein coding)
RECQL5 RecQ protein-like 5
RFPL2 ret finger protein-like 2
RGS5 regulator of G-protein signaling 5
RHEB Ras homolog enriched in brain
RIMS2 regulating synaptic membrane exocytosis 2
RPH3A rabphilin 3A
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SH3BP2 SH3-domain binding protein 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLAMF7 SLAM family member 7
SLC16A4 solute carrier family 16, member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMPX small muscle protein, X-linked
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYN3 synapsin III
TBRG4 transforming growth factor beta regulator 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPK2 uroplakin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZC3H13 zinc finger CCCH-type containing 13
ZFP2 ZFP2 zinc finger protein
ZNF549 zinc finger protein 549

decreased expression

Symbol Name
APH1B APH1B gamma secretase subunit
APOL6 apolipoprotein L, 6
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMCX2 armadillo repeat containing, X-linked 2
AXIN1 axin 1
BIRC3 baculoviral IAP repeat containing 3
C11ORF63 chromosome 11 open reading frame 63
C17ORF80 chromosome 17 open reading frame 80
C1ORF159 chromosome 1 open reading frame 159
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1S complement component 1, s subcomponent
C4ORF29 chromosome 4 open reading frame 29
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBR4 carbonyl reductase 4
CCDC25 coiled-coil domain containing 25
CCDC71 coiled-coil domain containing 71
CCDC9 coiled-coil domain containing 9
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CRMP1 collapsin response mediator protein 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DLL3 delta-like 3 (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DNAAF2 dynein, axonemal, assembly factor 2
DTX4 deltex 4, E3 ubiquitin ligase
DUSP9 dual specificity phosphatase 9
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGF epidermal growth factor
EN1 engrailed homeobox 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
EXD3 exonuclease 3'-5' domain containing 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FKBP8 FK506 binding protein 8, 38kDa
FOXN2 forkhead box N2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GSK3A glycogen synthase kinase 3 alpha
HDAC11 histone deacetylase 11
HIST1H4D histone cluster 1, H4d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA2 homeobox A2
HYAL3 hyaluronoglucosaminidase 3
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JUNB jun B proto-oncogene
KDM4D lysine (K)-specific demethylase 4D
KIAA0319L KIAA0319-like
KLHL25 kelch-like family member 25
KRT75 keratin 75, type II
LRP2 low density lipoprotein receptor-related protein 2
LRRC61 leucine rich repeat containing 61
MAGEA5 melanoma antigen family A5
MAPK12 mitogen-activated protein kinase 12
METTL22 methyltransferase like 22
MMP3 matrix metallopeptidase 3
MYL9 myosin, light chain 9, regulatory
NABP2 nucleic acid binding protein 2
NME5 NME/NM23 family member 5
OSGIN1 oxidative stress induced growth inhibitor 1
PALM paralemmin
PCOLCE procollagen C-endopeptidase enhancer
PELP1 proline, glutamate and leucine rich protein 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRR15L proline rich 15-like
PRR3 proline rich 3
PRR4 proline rich 4 (lacrimal)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD9A RAD9 homolog A (S. pombe)
RHOBTB2 Rho-related BTB domain containing 2
RNF31 ring finger protein 31
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUNX1-IT1 RUNX1 intronic transcript 1
SCAMP4 secretory carrier membrane protein 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SSBP3 single stranded DNA binding protein 3
SUN2 Sad1 and UNC84 domain containing 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNGR3 synaptogyrin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLN1 talin 1
TNRC6B trinucleotide repeat containing 6B
VEGFB vascular endothelial growth factor B
XAB2 XPA binding protein 2
ZNF254 zinc finger protein 254
ZNF358 zinc finger protein 358
ZNF778 zinc finger protein 778
ZYX zyxin