keratan sulfate biosynthesis Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. (Gene Ontology, GO_0018146)
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Genes

16 proteins participating in the keratan sulfate biosynthesis pathway from the KEGG Pathways dataset.

Symbol Name
B3GNT1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4