karakoline-4763 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the karakoline-4763 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD17B abhydrolase domain containing 17B
ADAM22 ADAM metallopeptidase domain 22
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATG10 autophagy related 10
ATP10B ATPase, class V, type 10B
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BTF3P11 basic transcription factor 3 pseudogene 11
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C4BPA complement component 4 binding protein, alpha
C5ORF42 chromosome 5 open reading frame 42
CDC14A cell division cycle 14A
CDRT1 CMT1A duplicated region transcript 1
CLCN4 chloride channel, voltage-sensitive 4
CPA4 carboxypeptidase A4
CSNK1G1 casein kinase 1, gamma 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DLC1 DLC1 Rho GTPase activating protein
DMP1 dentin matrix acidic phosphoprotein 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDN1 endothelin 1
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPYC epiphycan
ERN1 endoplasmic reticulum to nucleus signaling 1
FBXO2 F-box protein 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF18 fibroblast growth factor 18
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GFI1 growth factor independent 1 transcription repressor
GIF gastric intrinsic factor (vitamin B synthesis)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GP9 glycoprotein IX (platelet)
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSK3A glycogen synthase kinase 3 alpha
HBEGF heparin-binding EGF-like growth factor
HIPK3 homeodomain interacting protein kinase 3
HPX hemopexin
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICOSLG inducible T-cell co-stimulator ligand
IL18 interleukin 18
ITGA8 integrin, alpha 8
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMAN1 lectin, mannose-binding, 1
LMNB1 lamin B1
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED28 mediator complex subunit 28
METTL16 methyltransferase like 16
MRPL41 mitochondrial ribosomal protein L41
MTRF1L mitochondrial translational release factor 1-like
NF1 neurofibromin 1
NRL neural retina leucine zipper
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCLM oculomedin
PARD6B par-6 family cell polarity regulator beta
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH7 protocadherin 7
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHTF2 putative homeodomain transcription factor 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLXDC1 plexin domain containing 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSG5 pregnancy specific beta-1-glycoprotein 5
PTBP3 polypyrimidine tract binding protein 3
PTCRA pre T-cell antigen receptor alpha
RAB6A RAB6A, member RAS oncogene family
RB1 retinoblastoma 1
RGS14 regulator of G-protein signaling 14
RIMS3 regulating synaptic membrane exocytosis 3
RRBP1 ribosome binding protein 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A7 S100 calcium binding protein A7
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SP1 Sp1 transcription factor
STAB2 stabilin 2
STAC SH3 and cysteine rich domain
STAT2 signal transducer and activator of transcription 2, 113kDa
STK3 serine/threonine kinase 3
SYNC syncoilin, intermediate filament protein
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAS2R1 taste receptor, type 2, member 1
THOC5 THO complex 5
TM4SF4 transmembrane 4 L six family member 4
TMEM45A transmembrane protein 45A
TRIM10 tripartite motif containing 10
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSC22D4 TSC22 domain family, member 4
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZNF235 zinc finger protein 235
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMH anti-Mullerian hormone
AMPD1 adenosine monophosphate deaminase 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARPIN actin-related protein 2/3 complex inhibitor
ATAT1 alpha tubulin acetyltransferase 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C1ORF105 chromosome 1 open reading frame 105
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF46 chromosome 22 open reading frame 46
CAPN15 calpain 15
CD83 CD83 molecule
CD8A CD8a molecule
CEL carboxyl ester lipase
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCN6 chloride channel, voltage-sensitive 6
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
CNR2 cannabinoid receptor 2 (macrophage)
CORO7 coronin 7
CTAGE9 CTAGE family, member 9
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DRD1 dopamine receptor D1
DSPP dentin sialophosphoprotein
DVL1 dishevelled segment polarity protein 1
EDAR ectodysplasin A receptor
EGFL7 EGF-like-domain, multiple 7
ELP6 elongator acetyltransferase complex subunit 6
EVPL envoplakin
FAM155A family with sequence similarity 155, member A
FAM155B family with sequence similarity 155, member B
FFAR2 free fatty acid receptor 2
FKRP fukutin related protein
FLCN folliculin
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA9 gap junction protein, alpha 9, 59kDa
GPR153 G protein-coupled receptor 153
GSPT2 G1 to S phase transition 2
GUSBP3 glucuronidase, beta pseudogene 3
HCG4 HLA complex group 4 (non-protein coding)
HIST1H1E histone cluster 1, H1e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
HPN hepsin
IFT140 intraflagellar transport 140
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KREMEN2 kringle containing transmembrane protein 2
LINC01587 long intergenic non-protein coding RNA 1587
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MED9 mediator complex subunit 9
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYLK myosin light chain kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME5 NME/NM23 family member 5
NNAT neuronatin
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NUPR1 nuclear protein, transcriptional regulator, 1
PADI1 peptidyl arginine deiminase, type I
PCDHGA8 protocadherin gamma subfamily A, 8
PGR progesterone receptor
PLA2G1B phospholipase A2, group IB (pancreas)
PLAT plasminogen activator, tissue
PRSS53 protease, serine, 53
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A2 S100 calcium binding protein A2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIPA1 signal-induced proliferation-associated 1
SOX12 SRY (sex determining region Y)-box 12
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TEP1 telomerase-associated protein 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM53 transmembrane protein 53
TPCN1 two pore segment channel 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN5 tetraspanin 5
TTLL1 tubulin tyrosine ligase-like family member 1
UPK2 uroplakin 2
VASH1 vasohibin 1
WDR62 WD repeat domain 62
XAB2 XPA binding protein 2
YOD1 YOD1 deubiquitinase
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862