karakoline-4297 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the karakoline-4297 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACE2 angiotensin I converting enzyme 2
ACRV1 acrosomal vesicle protein 1
ADAMDEC1 ADAM-like, decysin 1
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AHI1 Abelson helper integration site 1
AIM2 absent in melanoma 2
ALDOB aldolase B, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP4 aquaporin 4
C10ORF10 chromosome 10 open reading frame 10
C9ORF156 chromosome 9 open reading frame 156
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD58 CD58 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLCA1 chloride channel accessory 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DGCR14 DiGeorge syndrome critical region gene 14
DMRT1 doublesex and mab-3 related transcription factor 1
DSTYK dual serine/threonine and tyrosine protein kinase
EDN1 endothelin 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPS8L3 EPS8-like 3
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
FAM46C family with sequence similarity 46, member C
FHL3 four and a half LIM domains 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GPM6B glycoprotein M6B
HHAT hedgehog acyltransferase
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HMGB3P1 high mobility group box 3 pseudogene 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGSF6 immunoglobulin superfamily, member 6
IRF4 interferon regulatory factor 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCTD14 potassium channel tetramerization domain containing 14
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LAT2 linker for activation of T cells family, member 2
LCMT2 leucine carboxyl methyltransferase 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MCF2L MCF.2 cell line derived transforming sequence-like
MINK1 misshapen-like kinase 1
MTNR1A melatonin receptor 1A
MUC3A mucin 3A, cell surface associated
MYO15B myosin XVB
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR7E19P olfactory receptor, family 7, subfamily E, member 19 pseudogene
OSR2 odd-skipped related transciption factor 2
PCDHB3 protocadherin beta 3
PKP4 plakophilin 4
PLXNA2 plexin A2
PRDX2 peroxiredoxin 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
PVT1 Pvt1 oncogene (non-protein coding)
QPCTL glutaminyl-peptide cyclotransferase-like
RAB40B RAB40B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RET ret proto-oncogene
RHEB Ras homolog enriched in brain
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAYSD1 SAYSVFN motif domain containing 1
SCN3B sodium channel, voltage gated, type III beta subunit
SEC14L4 SEC14-like 4 (S. cerevisiae)
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SFTPB surfactant protein B
SHOX2 short stature homeobox 2
SIRT4 sirtuin 4
SOX2 SRY (sex determining region Y)-box 2
SUGP1 SURP and G patch domain containing 1
TAPBP TAP binding protein (tapasin)
TBR1 T-box, brain, 1
TFR2 transferrin receptor 2
TMPO thymopoietin
TNNT2 troponin T type 2 (cardiac)
TP53I11 tumor protein p53 inducible protein 11
TRIM25 tripartite motif containing 25
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZNF280B zinc finger protein 280B
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ACSS3 acyl-CoA synthetase short-chain family member 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHDC1 AT hook, DNA binding motif, containing 1
ALOX12 arachidonate 12-lipoxygenase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
APOL6 apolipoprotein L, 6
ARMCX2 armadillo repeat containing, X-linked 2
AXIN1 axin 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C11ORF30 chromosome 11 open reading frame 30
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CBX8 chromobox homolog 8
CCDC7 coiled-coil domain containing 7
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD82 CD82 molecule
CDH7 cadherin 7, type 2
CEP41 centrosomal protein 41kDa
CFAP45 cilia and flagella associated protein 45
CHM choroideremia (Rab escort protein 1)
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNGA1 cyclic nucleotide gated channel alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DLK2 delta-like 2 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DMTN dematin actin binding protein
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GRAMD1C GRAM domain containing 1C
HHLA3 HERV-H LTR-associating 3
HOXA7 homeobox A7
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KLHL36 kelch-like family member 36
LIG4 ligase IV, DNA, ATP-dependent
LPPR4 lipid phosphate phosphatase-related protein type 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MFGE8 milk fat globule-EGF factor 8 protein
MTCP1 mature T-cell proliferation 1
MUC7 mucin 7, secreted
MYLK myosin light chain kinase
NABP2 nucleic acid binding protein 2
NCALD neurocalcin delta
NTSR1 neurotensin receptor 1 (high affinity)
OSMR oncostatin M receptor
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PALM paralemmin
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLXNB3 plexin B3
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRB3 proline-rich protein BstNI subfamily 3
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAI2 retinoic acid induced 2
RASL11B RAS-like, family 11, member B
RPA4 replication protein A4, 30kDa
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCN1B sodium channel, voltage gated, type I beta subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SETD1A SET domain containing 1A
SOX21 SRY (sex determining region Y)-box 21
SP1 Sp1 transcription factor
STRN4 striatin, calmodulin binding protein 4
SYT17 synaptotagmin XVII
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNS2 tensin 2
TOM1 target of myb1 (chicken)
TPST2 tyrosylprotein sulfotransferase 2
UNC93B1 unc-93 homolog B1 (C. elegans)
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
WNT10B wingless-type MMTV integration site family, member 10B
XAF1 XIAP associated factor 1
XDH xanthine dehydrogenase
ZNF222 zinc finger protein 222
ZNF230 zinc finger protein 230
ZNF426 zinc finger protein 426
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768
ZNF862 zinc finger protein 862