juxtaglomerular apparatus Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The juxtaglomerular apparatus is a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus. It is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005157)
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Genes

334 proteins co-occuring with the tissue juxtaglomerular apparatus in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
REN renin 3.62527
FLG filaggrin 1.70495
ENO2 enolase 2 (gamma, neuronal) 1.67256
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.59028
CD68 CD68 molecule 1.46449
LOR loricrin 1.43107
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.4034
AVP arginine vasopressin 1.39743
ACE angiotensin I converting enzyme 1.39238
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.36405
NOS1 nitric oxide synthase 1 (neuronal) 1.28502
TALDO1 transaldolase 1 1.28457
CA4 carbonic anhydrase IV 1.2394
IVL involucrin 1.23494
GJA5 gap junction protein, alpha 5, 40kDa 1.20823
DCX doublecortin 1.12748
GFAP glial fibrillary acidic protein 1.04269
LYZ lysozyme 1.02907
NPPA natriuretic peptide A 1.0085
CNFN cornifelin 0.989335
NOS3 nitric oxide synthase 3 (endothelial cell) 0.978917
CALB1 calbindin 1, 28kDa 0.97285
KRT2 keratin 2, type II 0.942645
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.938347
CA14 carbonic anhydrase XIV 0.919916
TMEM257 transmembrane protein 257 0.918633
DNAH8 dynein, axonemal, heavy chain 8 0.91052
SYP synaptophysin 0.885438
MB myoglobin 0.882897
CALB2 calbindin 2 0.834061
AQP2 aquaporin 2 (collecting duct) 0.831966
GJA4 gap junction protein, alpha 4, 37kDa 0.823175
PLBD2 phospholipase B domain containing 2 0.821502
KRT1 keratin 1, type II 0.813979
B3GAT1 beta-1,3-glucuronyltransferase 1 0.809386
UMOD uromodulin 0.806047
ACPP acid phosphatase, prostate 0.800626
FOS FBJ murine osteosarcoma viral oncogene homolog 0.773589
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.765711
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.765711
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.764468
TFE3 transcription factor binding to IGHM enhancer 3 0.750405
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.74834
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.744214
SOD2 superoxide dismutase 2, mitochondrial 0.737206
PTGES prostaglandin E synthase 0.733912
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.726097
CTSB cathepsin B 0.725685
ADORA1 adenosine A1 receptor 0.718703
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.717061
FOXO4 forkhead box O4 0.716241
FSTL5 follistatin-like 5 0.71501
NPY neuropeptide Y 0.7146
PQBP1 polyglutamine binding protein 1 0.71009
MLANA melan-A 0.70968
CD34 CD34 molecule 0.706402
MRS2 MRS2 magnesium transporter 0.70108
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.694537
BARHL1 BarH-like homeobox 1 0.681064
ABT1 activator of basal transcription 1 0.681064
TP53 tumor protein p53 0.67984
INHA inhibin, alpha 0.663555
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.661116
GJC1 gap junction protein, gamma 1, 45kDa 0.641643
PCNA proliferating cell nuclear antigen 0.639214
NIPAL4 NIPA-like domain containing 4 0.631931
ANKK1 ankyrin repeat and kinase domain containing 1 0.618603
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.6182
OLIG2 oligodendrocyte lineage transcription factor 2 0.606112
NGFR nerve growth factor receptor 0.598469
TGM1 transglutaminase 1 0.595656
FXYD2 FXYD domain containing ion transport regulator 2 0.589234
KRT10 keratin 10, type I 0.584422
PRKG2 protein kinase, cGMP-dependent, type II 0.584022
NTAN1 N-terminal asparagine amidase 0.574017
ELL elongation factor RNA polymerase II 0.557263
FLG2 filaggrin family member 2 0.554478
KRT16 keratin 16, type I 0.55249
MBP myelin basic protein 0.545739
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.544549
TCHH trichohyalin 0.543756
NGF nerve growth factor (beta polypeptide) 0.542963
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.540585
PTH parathyroid hormone 0.540585
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.536625
FXYD1 FXYD domain containing ion transport regulator 1 0.533065
AGTR1 angiotensin II receptor, type 1 0.530298
DOPEY2 dopey family member 2 0.522011
HAVCR1 hepatitis A virus cellular receptor 1 0.517284
PRKG1 protein kinase, cGMP-dependent, type I 0.505887
PVALB parvalbumin 0.500007
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.496092
GJA1 gap junction protein, alpha 1, 43kDa 0.496092
YY2 YY2 transcription factor 0.494918
TH tyrosine hydroxylase 0.494136
PGM1 phosphoglucomutase 1 0.484376
NOX4 NADPH oxidase 4 0.483986
CA13 carbonic anhydrase XIII 0.475034
NT5E 5'-nucleotidase, ecto (CD73) 0.468824
TNPO2 transportin 2 0.467273
G6PD glucose-6-phosphate dehydrogenase 0.464948
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 0.464561
HRNR hornerin 0.461465
BDNF brain-derived neurotrophic factor 0.461465
SNAP23 synaptosomal-associated protein, 23kDa 0.459918
SIGLEC10 sialic acid binding Ig-like lectin 10 0.459145
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.456828
PRCC papillary renal cell carcinoma (translocation-associated) 0.452584
SUCNR1 succinate receptor 1 0.449501
B3GALTL beta 1,3-galactosyltransferase-like 0.444115
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.44181
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.441426
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.434906
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 0.430312
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.428018
PLCD1 phospholipase C, delta 1 0.422292
SSTR3 somatostatin receptor 3 0.421529
F8 coagulation factor VIII, procoagulant component 0.411251
TGFB1 transforming growth factor, beta 1 0.41087
OCLN occludin 0.407453
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.406694
XAF1 XIAP associated factor 1 0.405935
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.405555
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.405555
FXYD4 FXYD domain containing ion transport regulator 4 0.401765
KRT7 keratin 7, type II 0.401386
ALB albumin 0.399114
COX11 COX11 cytochrome c oxidase copper chaperone 0.399114
FXYD7 FXYD domain containing ion transport regulator 7 0.397979
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.393819
POMC proopiomelanocortin 0.393442
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.392686
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.391176
KRT33A keratin 33A, type I 0.385896
GRM8 glutamate receptor, metabotropic 8 0.383637
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 0.377245
THY1 Thy-1 cell surface antigen 0.375743
ZRANB2 zinc finger, RAN-binding domain containing 2 0.371994
VIM vimentin 0.364886
GUCY2C guanylate cyclase 2C 0.364139
PMM2 phosphomannomutase 2 0.36302
NPR1 natriuretic peptide receptor 1 0.361901
CTSD cathepsin D 0.361155
ENO1 enolase 1, (alpha) 0.35557
PLB1 phospholipase B1 0.355198
TECTA tectorin alpha 0.354826
KRT8 keratin 8, type II 0.352598
JUN jun proto-oncogene 0.347778
CASR calcium-sensing receptor 0.345188
PROS1 protein S (alpha) 0.344449
EDA ectodysplasin A 0.342971
CLDN1 claudin 1 0.341126
NENF neudesin neurotrophic factor 0.340757
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.338545
CLDN7 claudin 7 0.334865
TNPO3 transportin 3 0.334498
S100A6 S100 calcium binding protein A6 0.33413
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.333396
CDKN2A cyclin-dependent kinase inhibitor 2A 0.332661
TNPO1 transportin 1 0.33156
DSG1 desmoglein 1 0.324239
FFAR3 free fatty acid receptor 3 0.322414
TARDBP TAR DNA binding protein 0.320591
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.319498
S100A9 S100 calcium binding protein A9 0.319134
AVPR2 arginine vasopressin receptor 2 0.315498
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.314409
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.310421
GJB4 gap junction protein, beta 4, 30.3kDa 0.309335
TJP1 tight junction protein 1 0.306444
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.306083
WNK4 WNK lysine deficient protein kinase 4 0.305361
DGKE diacylglycerol kinase, epsilon 64kDa 0.303919
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.303559
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 0.298883
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.298524
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.298165
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.297089
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.293866
KITLG KIT ligand 0.292793
C9ORF72 chromosome 9 open reading frame 72 0.289226
CRYAB crystallin, alpha B 0.289226
DUSP16 dual specificity phosphatase 16 0.289226
NES nestin 0.288514
CSTA cystatin A (stefin A) 0.287803
PTHLH parathyroid hormone-like hormone 0.286736
RICTOR RPTOR independent companion of MTOR, complex 2 0.284253
INS insulin 0.282483
RNASEH2A ribonuclease H2, subunit A 0.28213
STXBP1 syntaxin binding protein 1 0.280717
ALPPL2 alkaline phosphatase, placental-like 2 0.275444
ALPL alkaline phosphatase, liver/bone/kidney 0.274744
ALPP alkaline phosphatase, placental 0.274045
AGTRAP angiotensin II receptor-associated protein 0.270561
ACHE acetylcholinesterase (Yt blood group) 0.269174
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.268137
GCG glucagon 0.266413
GDI1 GDP dissociation inhibitor 1 0.265381
LGALS3 lectin, galactoside-binding, soluble, 3 0.265038
RELN reelin 0.262304
PDYN prodynorphin 0.260945
COL1A1 collagen, type I, alpha 1 0.25858
DAOA D-amino acid oxidase activator 0.258243
DUSP8 dual specificity phosphatase 8 0.2559
REG1B regenerating islet-derived 1 beta 0.251934
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.250627
ADCY2 adenylate cyclase 2 (brain) 0.250627
PTCH1 patched 1 0.249006
VIP vasoactive intestinal peptide 0.247719
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.247719
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.24676
PDE8A phosphodiesterase 8A 0.246442
SOX10 SRY (sex determining region Y)-box 10 0.246442
TEP1 telomerase-associated protein 1 0.246124
UNK unkempt family zinc finger 0.243605
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 0.241746
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.241746
PCSK1 proprotein convertase subtilisin/kexin type 1 0.241438
MAP2 microtubule-associated protein 2 0.241132
PYY peptide YY 0.24052
KRT20 keratin 20, type I 0.239913
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.239307
PSPC1 paraspeckle component 1 0.239007
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.238182
JUNB jun B proto-oncogene 0.235748
ADM adrenomedullin 0.235167
NEUROG2 neurogenin 2 0.232317
CYBA cytochrome b-245, alpha polypeptide 0.23176
TAC1 tachykinin, precursor 1 0.231206
CLDN4 claudin 4 0.230382
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.23011
ADSL adenylosuccinate lyase 0.23011
KNG1 kininogen 1 0.23011
YIPF2 Yip1 domain family, member 2 0.229839
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.229568
SLC26A7 solute carrier family 26 (anion exchanger), member 7 0.228234
WRB tryptophan rich basic protein 0.227186
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.2259
PSAP prosaposin 0.225144
DES desmin 0.221521
CDK5 cyclin-dependent kinase 5 0.221291
NTF3 neurotrophin 3 0.219264
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.21883
CA3 carbonic anhydrase III 0.218613
KLK7 kallikrein-related peptidase 7 0.216933
FGD1 FYVE, RhoGEF and PH domain containing 1 0.216528
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.21573
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.215341
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.215147
PCSK6 proprotein convertase subtilisin/kexin type 6 0.214954
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.213291
SST somatostatin 0.213112
ANXA5 annexin A5 0.212586
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.18788
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.187393
COL4A4 collagen, type IV, alpha 4 0.186897
POU3F3 POU class 3 homeobox 3 0.186627
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.186139
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.185734
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.185066
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.184909
IFT88 intraflagellar transport 88 0.184308
WTIP Wilms tumor 1 interacting protein 0.184208
STC1 stanniocalcin 1 0.184039
PRNP prion protein 0.183971
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.182407
PTGES2 prostaglandin E synthase 2 0.182271
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.181463
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.180997
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.180646
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.180513
STYK1 serine/threonine/tyrosine kinase 1 0.180423
AVPR1A arginine vasopressin receptor 1A 0.180241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.18015
NOX1 NADPH oxidase 1 0.180127
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.179777
DDR2 discoidin domain receptor tyrosine kinase 2 0.179047
MME membrane metallo-endopeptidase 0.177575
COL4A5 collagen, type IV, alpha 5 0.176838
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.176838
ACTB actin, beta 0.176808
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.176304
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.175339
ACTG1 actin gamma 1 0.175307
CA9 carbonic anhydrase IX 0.175275
ACSL4 acyl-CoA synthetase long-chain family member 4 0.175243
NELL2 NEL-like 2 (chicken) 0.175113
SIX4 SIX homeobox 4 0.174982
PDHX pyruvate dehydrogenase complex, component X 0.174751
STX3 syntaxin 3 0.174651
ODF1 outer dense fiber of sperm tails 1 0.174447
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.174346
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 0.174278
CTSH cathepsin H 0.174069
KLK1 kallikrein 1 0.174
FIG4 FIG4 phosphoinositide 5-phosphatase 0.173895
TERF2 telomeric repeat binding factor 2 0.173755
MAPT microtubule-associated protein tau 0.173719
BCL2L1 BCL2-like 1 0.173647
ANXA1 annexin A1 0.173576
QPRT quinolinate phosphoribosyltransferase 0.173576
PRMT1 protein arginine methyltransferase 1 0.173432
NR2E1 nuclear receptor subfamily 2, group E, member 1 0.173432
GRM2 glutamate receptor, metabotropic 2 0.173104
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.172657
WNK1 WNK lysine deficient protein kinase 1 0.172657
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.172466
AQP1 aquaporin 1 (Colton blood group) 0.172041
KRT5 keratin 5, type II 0.171962
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.171805
H3F3A H3 histone, family 3A 0.171363
H3F3B H3 histone, family 3B (H3.3B) 0.171363
PAGE5 P antigen family, member 5 (prostate associated) 0.171282
FAIM2 Fas apoptotic inhibitory molecule 2 0.170994
ATP11A ATPase, class VI, type 11A 0.170701
SON SON DNA binding protein 0.170448
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.170362
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.170362
TGM5 transglutaminase 5 0.170232
IL2 interleukin 2 0.170059
WT1 Wilms tumor 1 0.169796
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.169529
ASPN asporin 0.169396
CHGA chromogranin A 0.169214
PAPD7 PAP associated domain containing 7 0.169123
DSC1 desmocollin 1 0.168985
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.168893
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.168801
GPX1 glutathione peroxidase 1 0.168709
SS18 synovial sarcoma translocation, chromosome 18 0.168236
IQGAP1 IQ motif containing GTPase activating protein 1 0.168236
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.168236
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.168188
GPX5 glutathione peroxidase 5 0.167949