juvenile rheumatoid arthritis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. (Human Disease Ontology, DOID_676)
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Genes

208 genes co-occuring with the disease juvenile rheumatoid arthritis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.41911
IL1RN interleukin 1 receptor antagonist 1.69088
CRP C-reactive protein, pentraxin-related 1.52248
TNF tumor necrosis factor 1.41183
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.39695
IL6 interleukin 6 1.36161
MRAP melanocortin 2 receptor accessory protein 1.33938
IL6R interleukin 6 receptor 1.30445
WISP3 WNT1 inducible signaling pathway protein 3 1.2992
DEK DEK proto-oncogene 1.24211
VTCN1 V-set domain containing T cell activation inhibitor 1 1.17851
S100A12 S100 calcium binding protein A12 1.1541
CD79A CD79a molecule, immunoglobulin-associated alpha 1.14857
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 1.08244
IL1B interleukin 1, beta 1.07026
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.06018
NDEL1 nudE neurodevelopment protein 1-like 1 1.05765
HLA-C major histocompatibility complex, class I, C 1.02524
FAM177A1 family with sequence similarity 177, member A1 0.988535
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.987693
MEFV Mediterranean fever 0.986849
OR2B11 olfactory receptor, family 2, subfamily B, member 11 0.965825
CD4 CD4 molecule 0.942027
IL18 interleukin 18 0.927519
S100A9 S100 calcium binding protein A9 0.920498
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.911845
HLA-A major histocompatibility complex, class I, A 0.904032
TRAF1 TNF receptor-associated factor 1 0.879833
FOXP3 forkhead box P3 0.86714
UNC13D unc-13 homolog D (C. elegans) 0.838066
NLRP3 NLR family, pyrin domain containing 3 0.815514
PRF1 perforin 1 (pore forming protein) 0.807718
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.806898
MICALL2 MICAL-like 2 0.805257
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.799513
FTH1 ferritin, heavy polypeptide 1 0.792951
FTL ferritin, light polypeptide 0.792951
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.781479
S100A8 S100 calcium binding protein A8 0.777795
MMP3 matrix metallopeptidase 3 0.760231
BGLAP bone gamma-carboxyglutamate (gla) protein 0.745985
STAT4 signal transducer and activator of transcription 4 0.735027
IL1A interleukin 1, alpha 0.730166
IL2RA interleukin 2 receptor, alpha 0.726929
FCAMR Fc receptor, IgA, IgM, high affinity 0.722077
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.710378
SAA1 serum amyloid A1 0.705144
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.684692
PILRA paired immunoglobin-like type 2 receptor alpha 0.678701
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.674315
RSBN1 round spermatid basic protein 1 0.671925
CXCR3 chemokine (C-X-C motif) receptor 3 0.663975
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.654463
KIAA0391 KIAA0391 0.650903
LTA lymphotoxin alpha 0.62728
HMGB2 high mobility group box 2 0.623359
AFF3 AF4/FMR2 family, member 3 0.608494
IL15 interleukin 15 0.59952
ACAN aggrecan 0.591727
ADCK2 aarF domain containing kinase 2 0.588222
IL17A interleukin 17A 0.586276
PHB2 prohibitin 2 0.584719
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.584719
PTPRD protein tyrosine phosphatase, receptor type, D 0.578106
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.576939
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.568386
IGF1 insulin-like growth factor 1 (somatomedin C) 0.563335
NLRP2 NLR family, pyrin domain containing 2 0.562169
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.55518
PI16 peptidase inhibitor 16 0.550911
SELE selectin E 0.547807
NLRP11 NLR family, pyrin domain containing 11 0.545093
FSTL1 follistatin-like 1 0.528063
LYZ lysozyme 0.525746
JMJD1C jumonji domain containing 1C 0.517265
NLRP9 NLR family, pyrin domain containing 9 0.505739
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.503441
CD163 CD163 molecule 0.493503
CCR6 chemokine (C-C motif) receptor 6 0.488169
COMP cartilage oligomeric matrix protein 0.482844
MARK3 MAP/microtubule affinity-regulating kinase 3 0.482084
ADAM22 ADAM metallopeptidase domain 22 0.478289
CPLX3 complexin 3 0.474119
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.472982
IL10 interleukin 10 0.472604
ALPPL2 alkaline phosphatase, placental-like 2 0.464283
ALPP alkaline phosphatase, placental 0.463905
ALPL alkaline phosphatase, liver/bone/kidney 0.463149
ALB albumin 0.455978
IFNG interferon, gamma 0.455601
STX11 syntaxin 11 0.431894
ADGRE2 adhesion G protein-coupled receptor E2 0.430017
ZBTB25 zinc finger and BTB domain containing 25 0.42664
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.42289
RPS8 ribosomal protein S8 0.42139
IL4 interleukin 4 0.415398
TBRG1 transforming growth factor beta regulator 1 0.404557
ZFAT zinc finger and AT hook domain containing 0.399707
IGLV6-57 immunoglobulin lambda variable 6-57 0.396725
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.392257
IL2 interleukin 2 0.390397
STX17 syntaxin 17 0.385936
CD69 CD69 molecule 0.381852
MDC1 mediator of DNA-damage checkpoint 1 0.378885
IFNA13 interferon, alpha 13 0.374068
SH2D2A SH2 domain containing 2A 0.372587
COG6 component of oligomeric golgi complex 6 0.368888
PRG4 proteoglycan 4 0.368149
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.362978
MAGEB2 melanoma antigen family B2 0.360764
PRTN3 proteinase 3 0.359657
TGIF1 TGFB-induced factor homeobox 1 0.354499
CD27 CD27 molecule 0.35082
FCRL3 Fc receptor-like 3 0.35082
IGFBP3 insulin-like growth factor binding protein 3 0.339806
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.339806
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.335046
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.333583
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.328105
SAA2 serum amyloid A2 0.327375
TLR4 toll-like receptor 4 0.321909
CXCL10 chemokine (C-X-C motif) ligand 10 0.32009
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.315366
CD5 CD5 molecule 0.31029
CFC1 cripto, FRL-1, cryptic family 1 0.308842
HAPLN1 hyaluronan and proteoglycan link protein 1 0.304503
FST follistatin 0.304503
PRKCQ protein kinase C, theta 0.303059
ICAM1 intercellular adhesion molecule 1 0.303059
LPP LIM domain containing preferred translocation partner in lipoma 0.302337
HLA-B major histocompatibility complex, class I, B 0.299452
C3 complement component 3 0.298371
CXCR6 chemokine (C-X-C motif) receptor 6 0.28831
IPP intracisternal A particle-promoted polypeptide 0.287952
SH2B3 SH2B adaptor protein 3 0.287593
MYOM2 myomesin 2 0.285086
WDR11 WD repeat domain 11 0.283655
TIMP1 TIMP metallopeptidase inhibitor 1 0.276514
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.275445
RAB27A RAB27A, member RAS oncogene family 0.272241
CLEC4C C-type lectin domain family 4, member C 0.270819
CTSV cathepsin V 0.263368
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.261599
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.260891
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.259124
CD1C CD1c molecule 0.257005
HMGB3 high mobility group box 3 0.253831
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.252774
CD80 CD80 molecule 0.251015
CCL22 chemokine (C-C motif) ligand 22 0.249608
POMC proopiomelanocortin 0.247852
GSTM2 glutathione S-transferase mu 2 (muscle) 0.242945
GPX7 glutathione peroxidase 7 0.240847
NLE1 notchless homolog 1 (Drosophila) 0.237009
MVK mevalonate kinase 0.234573
TLR2 toll-like receptor 2 0.233878
PTH parathyroid hormone 0.231102
HLA-E major histocompatibility complex, class I, E 0.22937
SIK1 salt-inducible kinase 1 0.227642
CD226 CD226 molecule 0.227642
CD8B CD8b molecule 0.223853
ZMIZ1 zinc finger, MIZ-type containing 1 0.223509
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.223165
CD247 CD247 molecule 0.223165
CD276 CD276 molecule 0.221793
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.216672
IRF1 interferon regulatory factor 1 0.215653
CTPS1 CTP synthase 1 0.213621
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.212945
ATXN2 ataxin 2 0.211934
HBA2 hemoglobin, alpha 2 0.211597
MICA MHC class I polypeptide-related sequence A 0.211261
PRRC2A proline-rich coiled-coil 2A 0.210253
MBD5 methyl-CpG binding domain protein 5 0.208914
CCL5 chemokine (C-C motif) ligand 5 0.203604
MRPS7 mitochondrial ribosomal protein S7 0.200982
CCL20 chemokine (C-C motif) ligand 20 0.198709
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.19742
ANXA11 annexin A11 0.19742
DHFR dihydrofolate reductase 0.197099
MTX1 metaxin 1 0.193285
SAA4 serum amyloid A4, constitutive 0.191097
FAM131C family with sequence similarity 131, member C 0.187719
VIL1 villin 1 0.18472
CALCR calcitonin receptor 0.183541
NOD2 nucleotide-binding oligomerization domain containing 2 0.182666
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.180084
STAT5B signal transducer and activator of transcription 5B 0.178682
TRAF5 TNF receptor-associated factor 5 0.175146
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.174617
KSR1 kinase suppressor of ras 1 0.174093
C4B complement component 4B (Chido blood group) 0.173057
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.172799
SPP1 secreted phosphoprotein 1 0.171286
CYGB cytoglobin 0.169571
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.169571
SPAG7 sperm associated antigen 7 0.169091
CCL19 chemokine (C-C motif) ligand 19 0.168617
LIN9 lin-9 DREAM MuvB core complex component 0.165874
IL31RA interleukin 31 receptor A 0.165435
ANGPT1 angiopoietin 1 0.164571
HP haptoglobin 0.163111
F2R coagulation factor II (thrombin) receptor 0.162306
SAG S-antigen; retina and pineal gland (arrestin) 0.161523
HPR haptoglobin-related protein 0.160021
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.159658
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.15948
CCL2 chemokine (C-C motif) ligand 2 0.158778