jak-stat cascade involved in growth hormone signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. (Gene Ontology, GO_0060397)
External Link http://amigo.geneontology.org/amigo/term/GO:0060397
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Genes

24 genes participating in the jak-stat cascade involved in growth hormone signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
CISH cytokine inducible SH2-containing protein
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
PRL prolactin
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B