ivermectin-1367 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the ivermectin-1367 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
AGRN agrin
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANKRD40 ankyrin repeat domain 40
ASB8 ankyrin repeat and SOCS box containing 8
ATF2 activating transcription factor 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCLAF1 BCL2-associated transcription factor 1
BMP2K BMP2 inducible kinase
C5ORF28 chromosome 5 open reading frame 28
CBY1 chibby homolog 1 (Drosophila)
CDC73 cell division cycle 73
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHMP5 charged multivesicular body protein 5
CLCC1 chloride channel CLIC-like 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CTBS chitobiase, di-N-acetyl-
CTSS cathepsin S
DERL2 derlin 2
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLG3 discs, large homolog 3 (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DSCR3 Down syndrome critical region 3
EID1 EP300 interacting inhibitor of differentiation 1
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP1 endoplasmic reticulum aminopeptidase 1
EVI5 ecotropic viral integration site 5
FASTK Fas-activated serine/threonine kinase
FBXL5 F-box and leucine-rich repeat protein 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLT8D1 glycosyltransferase 8 domain containing 1
GPRC5D G protein-coupled receptor, class C, group 5, member D
GYPB glycophorin B (MNS blood group)
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IL18 interleukin 18
IL1RAP interleukin 1 receptor accessory protein
ITM2B integral membrane protein 2B
JMJD1C jumonji domain containing 1C
KIAA0226 KIAA0226
KIAA1109 KIAA1109
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
KRIT1 KRIT1, ankyrin repeat containing
KTN1 kinectin 1 (kinesin receptor)
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LINC00574 long intergenic non-protein coding RNA 574
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC40 leucine rich repeat containing 40
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MORC3 MORC family CW-type zinc finger 3
MYL10 myosin, light chain 10, regulatory
NENF neudesin neurotrophic factor
NET1 neuroepithelial cell transforming 1
PAQR3 progestin and adipoQ receptor family member III
PCNX pecanex homolog (Drosophila)
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDLIM1 PDZ and LIM domain 1
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP6R2 protein phosphatase 6, regulatory subunit 2
RAB28 RAB28, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RIOK3 RIO kinase 3
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCP2 sterol carrier protein 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SHROOM2 shroom family member 2
SIPA1 signal-induced proliferation-associated 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLK STE20-like kinase
SOCS5 suppressor of cytokine signaling 5
SRI sorcin
SRSF7 serine/arginine-rich splicing factor 7
STXBP3 syntaxin binding protein 3
SUMO1 small ubiquitin-like modifier 1
TCAF1 TRPM8 channel-associated factor 1
TMED7 transmembrane emp24 protein transport domain containing 7
TPT1 tumor protein, translationally-controlled 1
TSPAN31 tetraspanin 31
TTBK2 tau tubulin kinase 2
USF2 upstream transcription factor 2, c-fos interacting
XPA xeroderma pigmentosum, complementation group A
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YLPM1 YLP motif containing 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADM adrenomedullin
ANKRD28 ankyrin repeat domain 28
ASB13 ankyrin repeat and SOCS box containing 13
ATF7IP2 activating transcription factor 7 interacting protein 2
ATXN2 ataxin 2
C11ORF95 chromosome 11 open reading frame 95
C9ORF40 chromosome 9 open reading frame 40
CD82 CD82 molecule
CDK9 cyclin-dependent kinase 9
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CLTCL1 clathrin, heavy chain-like 1
CMTR1 cap methyltransferase 1
CNPY3 canopy FGF signaling regulator 3
COPS7B COP9 signalosome subunit 7B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSK cathepsin K
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOK2 docking protein 2, 56kDa
EPM2AIP1 EPM2A (laforin) interacting protein 1
ETV6 ets variant 6
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GLB1L2 galactosidase, beta 1-like 2
GMEB1 glucocorticoid modulatory element binding protein 1
GSK3B glycogen synthase kinase 3 beta
HAGH hydroxyacylglutathione hydrolase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HP haptoglobin
IFITM3 interferon induced transmembrane protein 3
IFNA17 interferon, alpha 17
IL4R interleukin 4 receptor
IRF9 interferon regulatory factor 9
ITPKC inositol-trisphosphate 3-kinase C
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL2 mitochondrial ribosomal protein L2
MTF1 metal-regulatory transcription factor 1
MYLIP myosin regulatory light chain interacting protein
MYNN myoneurin
NCF1C neutrophil cytosolic factor 1C pseudogene
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NFE2 nuclear factor, erythroid 2
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NSD1 nuclear receptor binding SET domain protein 1
NUBP2 nucleotide binding protein 2
NUP62 nucleoporin 62kDa
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORC3 origin recognition complex, subunit 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PARM1 prostate androgen-regulated mucin-like protein 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIGR polymeric immunoglobulin receptor
PISD phosphatidylserine decarboxylase
PMS2P5 postmeiotic segregation increased 2 pseudogene 5
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRR14L proline rich 14-like
PSKH1 protein serine kinase H1
RFX7 regulatory factor X, 7
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF220 ring finger protein 220
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAMP5 secretory carrier membrane protein 5
SDF2L1 stromal cell-derived factor 2-like 1
SEPW1 selenoprotein W, 1
SLC12A9 solute carrier family 12, member 9
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPATA20 spermatogenesis associated 20
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STRA13 stimulated by retinoic acid 13
STYXL1 serine/threonine/tyrosine interacting-like 1
TMPRSS6 transmembrane protease, serine 6
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPCN1 two pore segment channel 1
UNC45A unc-45 homolog A (C. elegans)
URGCP upregulator of cell proliferation
USB1 U6 snRNA biogenesis 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WBP2 WW domain binding protein 2
XAF1 XIAP associated factor 1
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC24 zinc finger, DHHC-type containing 24
ZDHHC7 zinc finger, DHHC-type containing 7
ZNF274 zinc finger protein 274
ZSCAN26 zinc finger and SCAN domain containing 26