isotretinoin-7315 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the isotretinoin-7315 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AK1 adenylate kinase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
APC adenomatous polyposis coli
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BICD1 bicaudal D homolog 1 (Drosophila)
C15ORF39 chromosome 15 open reading frame 39
C1S complement component 1, s subcomponent
C3 complement component 3
C7 complement component 7
C7ORF43 chromosome 7 open reading frame 43
CADPS2 Ca++-dependent secretion activator 2
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CDK13 cyclin-dependent kinase 13
CHD7 chromodomain helicase DNA binding protein 7
CPED1 cadherin-like and PC-esterase domain containing 1
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DCN decorin
DENND3 DENN/MADD domain containing 3
DLK1 delta-like 1 homolog (Drosophila)
DPF1 D4, zinc and double PHD fingers family 1
DSPP dentin sialophosphoprotein
FAM174B family with sequence similarity 174, member B
FAM63B family with sequence similarity 63, member B
FDX1 ferredoxin 1
FLJ11292
GAS7 growth arrest-specific 7
GOLGA2 golgin A2
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCTD13 potassium channel tetramerization domain containing 13
KLHL20 kelch-like family member 20
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MFAP3 microfibrillar-associated protein 3
MGP matrix Gla protein
MKL1 megakaryoblastic leukemia (translocation) 1
MXD4 MAX dimerization protein 4
NOTCH3 notch 3
PALM paralemmin
PDE4D phosphodiesterase 4D, cAMP-specific
PEG3 paternally expressed 3
PGP phosphoglycolate phosphatase
PRSS16 protease, serine, 16 (thymus)
PTGES prostaglandin E synthase
PTPN21 protein tyrosine phosphatase, non-receptor type 21
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
RNF122 ring finger protein 122
RPGRIP1L RPGRIP1-like
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEPP1 selenoprotein P, plasma, 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SULT4A1 sulfotransferase family 4A, member 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM63A transmembrane protein 63A
TNK1 tyrosine kinase, non-receptor, 1
TOP3A topoisomerase (DNA) III alpha
TTLL7 tubulin tyrosine ligase-like family member 7
TXLNG taxilin gamma
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
WDR25 WD repeat domain 25
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF253 zinc finger protein 253
ZNF44 zinc finger protein 44
ZNF440 zinc finger protein 440
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AFAP1 actin filament associated protein 1
AKTIP AKT interacting protein
ANAPC2 anaphase promoting complex subunit 2
ANKRD36 ankyrin repeat domain 36
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA2P3 annexin A2 pseudogene 3
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAG4 BCL2-associated athanogene 4
BCL9 B-cell CLL/lymphoma 9
BDNF brain-derived neurotrophic factor
C11ORF73 chromosome 11 open reading frame 73
C4ORF29 chromosome 4 open reading frame 29
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCP110 centriolar coiled coil protein 110kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CST4 cystatin S
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
ELOVL4 ELOVL fatty acid elongase 4
FAM50B family with sequence similarity 50, member B
FBXL14 F-box and leucine-rich repeat protein 14
FBXL6 F-box and leucine-rich repeat protein 6
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDAP1 ganglioside induced differentiation associated protein 1
GDAP2 ganglioside induced differentiation associated protein 2
GID4 GID complex subunit 4
GJC1 gap junction protein, gamma 1, 45kDa
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
IL17RA interleukin 17 receptor A
IL33 interleukin 33
IPP intracisternal A particle-promoted polypeptide
IRAK4 interleukin-1 receptor-associated kinase 4
IREB2 iron-responsive element binding protein 2
LYPD1 LY6/PLAUR domain containing 1
MAGEF1 melanoma antigen family F1
MAP1S microtubule-associated protein 1S
MLYCD malonyl-CoA decarboxylase
MMP13 matrix metallopeptidase 13
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NTSR1 neurotensin receptor 1 (high affinity)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX9 paired box 9
PDE12 phosphodiesterase 12
PHC1 polyhomeotic homolog 1 (Drosophila)
POLM polymerase (DNA directed), mu
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB23 RAB23, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHOBTB2 Rho-related BTB domain containing 2
RPAP1 RNA polymerase II associated protein 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNDC3B RUN domain containing 3B
RWDD2A RWD domain containing 2A
S100A3 S100 calcium binding protein A3
SCARA3 scavenger receptor class A, member 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SSBP3 single stranded DNA binding protein 3
SSFA2 sperm specific antigen 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNPO synaptopodin
TAGLN3 transgelin 3
TBC1D19 TBC1 domain family, member 19
TEP1 telomerase-associated protein 1
TH tyrosine hydroxylase
TM7SF3 transmembrane 7 superfamily member 3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSKU tsukushi, small leucine rich proteoglycan
TUBG2 tubulin, gamma 2
USP18 ubiquitin specific peptidase 18
VWA1 von Willebrand factor A domain containing 1
WDR76 WD repeat domain 76
ZC3H12A zinc finger CCCH-type containing 12A
ZNF267 zinc finger protein 267
ZNF273 zinc finger protein 273
ZNF350 zinc finger protein 350
ZNF358 zinc finger protein 358
ZNF701 zinc finger protein 701
ZNF711 zinc finger protein 711
ZNF767P zinc finger family member 767, pseudogene