isoniazid-2246 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the isoniazid-2246 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADCK4 aarF domain containing kinase 4
ADGRG1 adhesion G protein-coupled receptor G1
AFF1 AF4/FMR2 family, member 1
AHNAK AHNAK nucleoprotein
AMPD3 adenosine monophosphate deaminase 3
AMPH amphiphysin
APOL6 apolipoprotein L, 6
AQP1 aquaporin 1 (Colton blood group)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATF7IP activating transcription factor 7 interacting protein
BAIAP3 BAI1-associated protein 3
BCAN brevican
BMP6 bone morphogenetic protein 6
C9ORF156 chromosome 9 open reading frame 156
CAMK1G calcium/calmodulin-dependent protein kinase IG
CCL19 chemokine (C-C motif) ligand 19
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFAP45 cilia and flagella associated protein 45
CLCN1 chloride channel, voltage-sensitive 1
COMP cartilage oligomeric matrix protein
CREB3L1 cAMP responsive element binding protein 3-like 1
CRHR1 corticotropin releasing hormone receptor 1
CRMP1 collapsin response mediator protein 1
CSDC2 cold shock domain containing C2, RNA binding
CTNS cystinosin, lysosomal cystine transporter
CXXC4 CXXC finger protein 4
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCC DCC netrin 1 receptor
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGCR8 DGCR8 microprocessor complex subunit
DLK2 delta-like 2 homolog (Drosophila)
DNAH9 dynein, axonemal, heavy chain 9
DUSP6 dual specificity phosphatase 6
EML2 echinoderm microtubule associated protein like 2
EXOSC1 exosome component 1
FRMPD1 FERM and PDZ domain containing 1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPM6A glycoprotein M6A
GRM1 glutamate receptor, metabotropic 1
HBEGF heparin-binding EGF-like growth factor
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BN histone cluster 1, H2bn
HNF1B HNF1 homeobox B
IDUA iduronidase, alpha-L-
INHBE inhibin, beta E
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IQCC IQ motif containing C
KAT6A K(lysine) acetyltransferase 6A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1462 KIAA1462
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
LTB4R leukotriene B4 receptor
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MINK1 misshapen-like kinase 1
MSX2 msh homeobox 2
MTSS1L metastasis suppressor 1-like
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
OAZ3 ornithine decarboxylase antizyme 3
OR2F2 olfactory receptor, family 2, subfamily F, member 2
PDCD6 programmed cell death 6
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PON1 paraoxonase 1
PSG3 pregnancy specific beta-1-glycoprotein 3
RB1 retinoblastoma 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SDC2 syndecan 2
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC8 sialic acid binding Ig-like lectin 8
SIRT5 sirtuin 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX15 SRY (sex determining region Y)-box 15
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
SULT4A1 sulfotransferase family 4A, member 1
TACC1 transforming, acidic coiled-coil containing protein 1
TM4SF4 transmembrane 4 L six family member 4
TMOD2 tropomodulin 2 (neuronal)
TRD T cell receptor delta locus
TRIM38 tripartite motif containing 38
TSHR thyroid stimulating hormone receptor
TTC22 tetratricopeptide repeat domain 22
USP12 ubiquitin specific peptidase 12
USP46 ubiquitin specific peptidase 46
ZNF44 zinc finger protein 44
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABLIM3 actin binding LIM protein family, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BCAS1 breast carcinoma amplified sequence 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CCDC132 coiled-coil domain containing 132
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDON cell adhesion associated, oncogene regulated
CISH cytokine inducible SH2-containing protein
CUZD1 CUB and zona pellucida-like domains 1
DBR1 debranching RNA lariats 1
DGAT1 diacylglycerol O-acyltransferase 1
DGKZ diacylglycerol kinase, zeta
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSCAM Down syndrome cell adhesion molecule
EMID1 EMI domain containing 1
FKBP5 FK506 binding protein 5
FRS2 fibroblast growth factor receptor substrate 2
GATA4 GATA binding protein 4
GCC1 GRIP and coiled-coil domain containing 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HDAC5 histone deacetylase 5
HELZ helicase with zinc finger
HIST1H2BC histone cluster 1, H2bc
HIST1H3B histone cluster 1, H3b
HLA-J major histocompatibility complex, class I, J (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
HPN hepsin
IFI35 interferon-induced protein 35
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
ITPKB inositol-trisphosphate 3-kinase B
KCTD20 potassium channel tetramerization domain containing 20
KDM7A lysine (K)-specific demethylase 7A
KLK5 kallikrein-related peptidase 5
KRI1 KRI1 homolog (S. cerevisiae)
KRT8P12 keratin 8 pseudogene 12
LAMA3 laminin, alpha 3
LHX6 LIM homeobox 6
LOC730101 uncharacterized LOC730101
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYPD1 LY6/PLAUR domain containing 1
LYRM9 LYR motif containing 9
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MGC12488
MT1H metallothionein 1H
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
NPTX1 neuronal pentraxin I
P3H1 prolyl 3-hydroxylase 1
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PILRB paired immunoglobin-like type 2 receptor beta
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
ROM1 retinal outer segment membrane protein 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SNX15 sorting nexin 15
SPRYD7 SPRY domain containing 7
SREBF2 sterol regulatory element binding transcription factor 2
STX1A syntaxin 1A (brain)
SYTL2 synaptotagmin-like 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TDRD1 tudor domain containing 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TXLNG taxilin gamma
UBQLN4 ubiquilin 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR62 WD repeat domain 62
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF134 zinc finger protein 134
ZNF250 zinc finger protein 250
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF696 zinc finger protein 696