isometheptene-5502 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the isometheptene-5502 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AFF1 AF4/FMR2 family, member 1
APC adenomatous polyposis coli
APOLD1 apolipoprotein L domain containing 1
ARTN artemin
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL2 B-cell CLL/lymphoma 2
BMP8A bone morphogenetic protein 8a
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCNT2 cyclin T2
CCP110 centriolar coiled coil protein 110kDa
CDRT1 CMT1A duplicated region transcript 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFAP45 cilia and flagella associated protein 45
CLDN15 claudin 15
CLIP2 CAP-GLY domain containing linker protein 2
CLTA clathrin, light chain A
CTNS cystinosin, lysosomal cystine transporter
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DENND3 DENN/MADD domain containing 3
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMBT1 deleted in malignant brain tumors 1
DNAI2 dynein, axonemal, intermediate chain 2
DRD2 dopamine receptor D2
ERCC2 excision repair cross-complementation group 2
ERP44 endoplasmic reticulum protein 44
EXOC7 exocyst complex component 7
FAM149B1 family with sequence similarity 149, member B1
FBXO21 F-box protein 21
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF13 fibroblast growth factor 13
FH fumarate hydratase
FKBPL FK506 binding protein like
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
GPC4 glypican 4
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GTDC1 glycosyltransferase-like domain containing 1
HAP1 huntingtin-associated protein 1
HIST1H1D histone cluster 1, H1d
HNMT histamine N-methyltransferase
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEL Kell blood group, metallo-endopeptidase
KIAA1644 KIAA1644
LMF1 lipase maturation factor 1
LMO7 LIM domain 7
LOC647070 uncharacterized LOC647070
LRRC61 leucine rich repeat containing 61
LUZP1 leucine zipper protein 1
MAP2K2 mitogen-activated protein kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYOF myoferlin
NCAPH2 non-SMC condensin II complex, subunit H2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPM3 nucleophosmin/nucleoplasmin 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NXT2 nuclear transport factor 2-like export factor 2
PCDHB3 protocadherin beta 3
PEX11A peroxisomal biogenesis factor 11 alpha
PEX26 peroxisomal biogenesis factor 26
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POU5F1B POU class 5 homeobox 1B
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKG2 protein kinase, cGMP-dependent, type II
PRLR prolactin receptor
PRPF31 pre-mRNA processing factor 31
PTBP3 polypyrimidine tract binding protein 3
PVT1 Pvt1 oncogene (non-protein coding)
QTRT1 queuine tRNA-ribosyltransferase 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTEL1 regulator of telomere elongation helicase 1
S100A2 S100 calcium binding protein A2
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35E2 solute carrier family 35, member E2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNX13 sorting nexin 13
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STRN3 striatin, calmodulin binding protein 3
STX2 syntaxin 2
TBX2 T-box 2
TFPI2 tissue factor pathway inhibitor 2
TK1 thymidine kinase 1, soluble
TMEM209 transmembrane protein 209
TRIM21 tripartite motif containing 21
VNN2 vanin 2
ZNF286A zinc finger protein 286A

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
AFF4 AF4/FMR2 family, member 4
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATAD5 ATPase family, AAA domain containing 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
CLEC4E C-type lectin domain family 4, member E
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRLF1 cytokine receptor-like factor 1
DNAL4 dynein, axonemal, light chain 4
DOCK1 dedicator of cytokinesis 1
F2R coagulation factor II (thrombin) receptor
FAM155A family with sequence similarity 155, member A
FAM189A2 family with sequence similarity 189, member A2
FAM86C1 family with sequence similarity 86, member C1
FKBP14 FK506 binding protein 14, 22 kDa
FMO4 flavin containing monooxygenase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GOLGA8B golgin A8 family, member B
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H3B histone cluster 1, H3b
IL17RA interleukin 17 receptor A
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT13 keratin 13, type I
LARP6 La ribonucleoprotein domain family, member 6
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LHX1 LIM homeobox 1
LIME1 Lck interacting transmembrane adaptor 1
LIN7B lin-7 homolog B (C. elegans)
LOC100286895 cell division cycle 27 homolog pseudogene
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MED15 mediator complex subunit 15
MUC3A mucin 3A, cell surface associated
NAG18 NAG18 mRNA
NHEJ1 nonhomologous end-joining factor 1
NOL12 nucleolar protein 12
OGFRL1 opioid growth factor receptor-like 1
ONECUT2 one cut homeobox 2
PAQR6 progestin and adipoQ receptor family member VI
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRODH proline dehydrogenase (oxidase) 1
RECQL4 RecQ protein-like 4
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SETD1A SET domain containing 1A
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPIDR scaffolding protein involved in DNA repair
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLR5 toll-like receptor 5
TMEM183A transmembrane protein 183A
TMEM51 transmembrane protein 51
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TWF2 twinfilin actin binding protein 2
UBXN6 UBX domain protein 6
UPK3B uroplakin 3B
WDR7 WD repeat domain 7
WDR91 WD repeat domain 91
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZC3H3 zinc finger CCCH-type containing 3
ZNF652 zinc finger protein 652
ZNF668 zinc finger protein 668
ZNF669 zinc finger protein 669
ZNF675 zinc finger protein 675
ZNF701 zinc finger protein 701