isometheptene-3145 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the isometheptene-3145 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANGPTL2 angiopoietin-like 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
ARMCX4 armadillo repeat containing, X-linked 4
BLVRB biliverdin reductase B
C11ORF16 chromosome 11 open reading frame 16
CA5B carbonic anhydrase VB, mitochondrial
CABP2 calcium binding protein 2
CAMKMT calmodulin-lysine N-methyltransferase
CCDC71 coiled-coil domain containing 71
CD6 CD6 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDON cell adhesion associated, oncogene regulated
CEND1 cell cycle exit and neuronal differentiation 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CNPY4 canopy FGF signaling regulator 4
CTSZ cathepsin Z
DCAKD dephospho-CoA kinase domain containing
DNAH17 dynein, axonemal, heavy chain 17
DSTYK dual serine/threonine and tyrosine protein kinase
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENG endoglin
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FAM149A family with sequence similarity 149, member A
FGF23 fibroblast growth factor 23
FOSL2 FOS-like antigen 2
FRMD8 FERM domain containing 8
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAP43 growth associated protein 43
GATA4 GATA binding protein 4
GNL1 guanine nucleotide binding protein-like 1
GOLGA8A golgin A8 family, member A
GPR132 G protein-coupled receptor 132
GPR21 G protein-coupled receptor 21
GSPT1 G1 to S phase transition 1
GUCY2F guanylate cyclase 2F, retinal
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HOXA10 homeobox A10
HOXC8 homeobox C8
HSPA2 heat shock 70kDa protein 2
HTRA1 HtrA serine peptidase 1
IFIH1 interferon induced with helicase C domain 1
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
INPP5J inositol polyphosphate-5-phosphatase J
KHK ketohexokinase (fructokinase)
KIAA1024 KIAA1024
KLF3 Kruppel-like factor 3 (basic)
KLHL22 kelch-like family member 22
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LPPR1 lipid phosphate phosphatase-related protein type 1
MAST2 microtubule associated serine/threonine kinase 2
MMP25 matrix metallopeptidase 25
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR3 myotubularin related protein 3
MUC8 mucin 8
MXD1 MAX dimerization protein 1
MXD4 MAX dimerization protein 4
MYOZ2 myozenin 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
ORAI2 ORAI calcium release-activated calcium modulator 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCBP4 poly(rC) binding protein 4
PDLIM5 PDZ and LIM domain 5
PSG1 pregnancy specific beta-1-glycoprotein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTPRK protein tyrosine phosphatase, receptor type, K
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
SCAND2P SCAN domain containing 2 pseudogene
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIRT3 sirtuin 3
SLITRK5 SLIT and NTRK-like family, member 5
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNCG synuclein, gamma (breast cancer-specific protein 1)
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYN3 synapsin III
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TLN2 talin 2
TNC tenascin C
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIM10 tripartite motif containing 10
UROD uroporphyrinogen decarboxylase
VIPR2 vasoactive intestinal peptide receptor 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF362 zinc finger protein 362
ZNF407 zinc finger protein 407
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ANKRD55 ankyrin repeat domain 55
APH1B APH1B gamma secretase subunit
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARMC7 armadillo repeat containing 7
AXIN1 axin 1
BEST1 bestrophin 1
C1ORF105 chromosome 1 open reading frame 105
C1ORF159 chromosome 1 open reading frame 159
CD1D CD1d molecule
CD34 CD34 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CECR1 cat eye syndrome chromosome region, candidate 1
CLEC2D C-type lectin domain family 2, member D
CNTN1 contactin 1
CPA2 carboxypeptidase A2 (pancreatic)
CPNE1 copine I
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCAF13 DDB1 and CUL4 associated factor 13
DGKG diacylglycerol kinase, gamma 90kDa
EHD3 EH-domain containing 3
EMILIN2 elastin microfibril interfacer 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC2 excision repair cross-complementation group 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM53B family with sequence similarity 53, member B
FBXL6 F-box and leucine-rich repeat protein 6
FCHO1 FCH domain only 1
FKBP8 FK506 binding protein 8, 38kDa
FOXC1 forkhead box C1
FOXO4 forkhead box O4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HLA-DMB major histocompatibility complex, class II, DM beta
IDI2-AS1 IDI2 antisense RNA 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA14 interferon, alpha 14
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
KIAA0754 KIAA0754
LGALS4 lectin, galactoside-binding, soluble, 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LINC00260 long intergenic non-protein coding RNA 260
LOC100286895 cell division cycle 27 homolog pseudogene
LRRK1 leucine-rich repeat kinase 1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MFSD12 major facilitator superfamily domain containing 12
MFSD6 major facilitator superfamily domain containing 6
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MOSPD3 motile sperm domain containing 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PADI1 peptidyl arginine deiminase, type I
PCDHGA10 protocadherin gamma subfamily A, 10
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLCD1 phospholipase C, delta 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PRF1 perforin 1 (pore forming protein)
QPCTL glutaminyl-peptide cyclotransferase-like
RASAL1 RAS protein activator like 1 (GAP1 like)
RHOBTB2 Rho-related BTB domain containing 2
RNF122 ring finger protein 122
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAI1 snail family zinc finger 1
SOX12 SRY (sex determining region Y)-box 12
SP140 SP140 nuclear body protein
SP4 Sp4 transcription factor
SPATA20 spermatogenesis associated 20
ST5 suppression of tumorigenicity 5
SYTL2 synaptotagmin-like 2
TAS2R4 taste receptor, type 2, member 4
TBC1D19 TBC1 domain family, member 19
TBXAS1 thromboxane A synthase 1 (platelet)
TMEM212 transmembrane protein 212
TMEM242 transmembrane protein 242
TMEM246 transmembrane protein 246
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAF1 TNF receptor-associated factor 1
TSNAXIP1 translin-associated factor X interacting protein 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBTD1 ubiquitin domain containing 1
VEGFC vascular endothelial growth factor C
WNT16 wingless-type MMTV integration site family, member 16
XAB2 XPA binding protein 2
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZFHX4 zinc finger homeobox 4
ZNF185 zinc finger protein 185 (LIM domain)
ZNF778 zinc finger protein 778