isoconazole-2218 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the isoconazole-2218 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1C1 aldo-keto reductase family 1, member C1
ANGEL2 angel homolog 2 (Drosophila)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF3 activating transcription factor 3
BDKRB2 bradykinin receptor B2
BMP8B bone morphogenetic protein 8b
BTNL3 butyrophilin-like 3
C19ORF66 chromosome 19 open reading frame 66
C9ORF156 chromosome 9 open reading frame 156
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD47 CD47 molecule
CFAP45 cilia and flagella associated protein 45
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN4 chloride channel, voltage-sensitive 4
COL1A1 collagen, type I, alpha 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTH cystathionine gamma-lyase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DGCR2 DiGeorge syndrome critical region gene 2
DLX2 distal-less homeobox 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP4 dual specificity phosphatase 4
EFNB3 ephrin-B3
EGR1 early growth response 1
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GEM GTP binding protein overexpressed in skeletal muscle
GPM6A glycoprotein M6A
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HPS1 Hermansky-Pudlak syndrome 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHBE inhibin, beta E
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA1107 KIAA1107
KIFC3 kinesin family member C3
KIZ kizuna centrosomal protein
KLHL20 kelch-like family member 20
KLHL29 kelch-like family member 29
LARP6 La ribonucleoprotein domain family, member 6
LRP12 low density lipoprotein receptor-related protein 12
LTB4R leukotriene B4 receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MATN3 matrilin 3
MLXIP MLX interacting protein
MYCNOS MYCN opposite strand
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDNF neuron-derived neurotrophic factor
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP188 nucleoporin 188kDa
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PHF8 PHD finger protein 8
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB33A RAB33A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM5 RNA binding motif protein 5
REEP2 receptor accessory protein 2
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
SERHL2 serine hydrolase-like 2
SH2B1 SH2B adaptor protein 1
SH3BP2 SH3-domain binding protein 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS2 son of sevenless homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SRD5A3 steroid 5 alpha-reductase 3
TCF12 transcription factor 12
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM209 transmembrane protein 209
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
WNT5A wingless-type MMTV integration site family, member 5A
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XYLB xylulokinase homolog (H. influenzae)
ZBTB22 zinc finger and BTB domain containing 22
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRE5 adhesion G protein-coupled receptor E5
ALS2CL ALS2 C-terminal like
ANXA2P3 annexin A2 pseudogene 3
APOLD1 apolipoprotein L domain containing 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
C9ORF9 chromosome 9 open reading frame 9
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALML5 calmodulin-like 5
CD80 CD80 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CLGN calmegin
CORT cortistatin
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCAF13 DDB1 and CUL4 associated factor 13
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNM1 dynamin 1
DTX2 deltex 2, E3 ubiquitin ligase
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPPK1 epiplakin 1
ETAA1 Ewing tumor-associated antigen 1
ETNK2 ethanolamine kinase 2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GIF gastric intrinsic factor (vitamin B synthesis)
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
GSTM5 glutathione S-transferase mu 5
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1 host cell factor C1
HIST1H1D histone cluster 1, H1d
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
IQSEC2 IQ motif and Sec7 domain 2
KDM8 lysine (K)-specific demethylase 8
KRT15 keratin 15, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LHX6 LIM homeobox 6
LINC00597 long intergenic non-protein coding RNA 597
LOC100287590 uncharacterized LOC100287590
LRP5L low density lipoprotein receptor-related protein 5-like
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEB2 melanoma antigen family B2
MTA2 metastasis associated 1 family, member 2
MYOZ1 myozenin 1
NIPAL2 NIPA-like domain containing 2
NOL10 nucleolar protein 10
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCAN3 RCAN family member 3
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF208 ring finger protein 208
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A9 S100 calcium binding protein A9
SCML2 sex comb on midleg-like 2 (Drosophila)
SDC3 syndecan 3
SETD1A SET domain containing 1A
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIPA1 signal-induced proliferation-associated 1
SIRT6 sirtuin 6
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SPRYD7 SPRY domain containing 7
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STMN3 stathmin-like 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM104 transmembrane protein 104
TMEM121 transmembrane protein 121
TMPRSS4 transmembrane protease, serine 4
TNS2 tensin 2
UNC119 unc-119 homolog (C. elegans)
WNT10B wingless-type MMTV integration site family, member 10B
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZIC3 Zic family member 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF804A zinc finger protein 804A
ZNF85 zinc finger protein 85