isocarboxazid-7383 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the isocarboxazid-7383 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADCY6 adenylate cyclase 6
ADGRL1 adhesion G protein-coupled receptor L1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARID1A AT rich interactive domain 1A (SWI-like)
ARL15 ADP-ribosylation factor-like 15
ASTN2 astrotactin 2
ATAT1 alpha tubulin acetyltransferase 1
ATP13A2 ATPase type 13A2
ATXN7L1 ataxin 7-like 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C9ORF40 chromosome 9 open reading frame 40
CLDN11 claudin 11
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNPPD1 cyclin Pas1/PHO80 domain containing 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK5 dedicator of cytokinesis 5
EMC1 ER membrane protein complex subunit 1
EPHB2 EPH receptor B2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERO1LB ERO1-like beta (S. cerevisiae)
ETV1 ets variant 1
FAM160B2 family with sequence similarity 160, member B2
FAM69A family with sequence similarity 69, member A
FASTKD2 FAST kinase domains 2
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FGF13 fibroblast growth factor 13
FKBP10 FK506 binding protein 10, 65 kDa
FLT1 fms-related tyrosine kinase 1
FRMPD1 FERM and PDZ domain containing 1
FYB FYN binding protein
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HOOK1 hook microtubule-tethering protein 1
HOXA4 homeobox A4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHMBP2 immunoglobulin mu binding protein 2
IL11 interleukin 11
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIF5C kinesin family member 5C
LEF1 lymphoid enhancer-binding factor 1
LIMK2 LIM domain kinase 2
MAK male germ cell-associated kinase
MAP1B microtubule-associated protein 1B
MAPT microtubule-associated protein tau
MBD2 methyl-CpG binding domain protein 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
METTL7A methyltransferase like 7A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
MRPS12 mitochondrial ribosomal protein S12
MX1 MX dynamin-like GTPase 1
NELL2 NEL-like 2 (chicken)
NPEPL1 aminopeptidase-like 1
ORC5 origin recognition complex, subunit 5
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PASK PAS domain containing serine/threonine kinase
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PEX6 peroxisomal biogenesis factor 6
PICALM phosphatidylinositol binding clathrin assembly protein
PICK1 protein interacting with PRKCA 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK4 polo-like kinase 4
RAB31 RAB31, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RARG retinoic acid receptor, gamma
RBM34 RNA binding motif protein 34
RNASE4 ribonuclease, RNase A family, 4
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SAPCD1 suppressor APC domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SP1 Sp1 transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SREBF2 sterol regulatory element binding transcription factor 2
SYCP1 synaptonemal complex protein 1
TBCD tubulin folding cofactor D
TEX40 testis expressed 40
TMEM231 transmembrane protein 231
TNK1 tyrosine kinase, non-receptor, 1
TRIM3 tripartite motif containing 3
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSFM Ts translation elongation factor, mitochondrial
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ZER1 zyg-11 related, cell cycle regulator
ZNF224 zinc finger protein 224
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ACVR2B activin A receptor, type IIB
ADGRF1 adhesion G protein-coupled receptor F1
AFAP1 actin filament associated protein 1
AHR aryl hydrocarbon receptor
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNT1 cyclin T1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDH7 cadherin 7, type 2
CDON cell adhesion associated, oncogene regulated
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
CLEC16A C-type lectin domain family 16, member A
CLEC2B C-type lectin domain family 2, member B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CTSK cathepsin K
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOCK1 dedicator of cytokinesis 1
ELP6 elongator acetyltransferase complex subunit 6
ELSPBP1 epididymal sperm binding protein 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPPK1 epiplakin 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALK1 galactokinase 1
HIST1H2AG histone cluster 1, H2ag
JUNB jun B proto-oncogene
KIAA0895 KIAA0895
KIAA1462 KIAA1462
KRT15 keratin 15, type I
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MED22 mediator complex subunit 22
MOXD1 monooxygenase, DBH-like 1
MTERF4 mitochondrial transcription termination factor 4
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCS1 neuronal calcium sensor 1
NPR3 natriuretic peptide receptor 3
NT5M 5',3'-nucleotidase, mitochondrial
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PBLD phenazine biosynthesis-like protein domain containing
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK6 protein tyrosine kinase 6
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB3A RAB3A, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF2 ring finger protein 2
RPP25 ribonuclease P/MRP 25kDa subunit
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SECISBP2 SECIS binding protein 2
SECTM1 secreted and transmembrane 1
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A40 solute carrier family 25, member 40
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SP140L SP140 nuclear body protein-like
SPEG SPEG complex locus
SPRYD7 SPRY domain containing 7
SRD5A3 steroid 5 alpha-reductase 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIGD6 tigger transposable element derived 6
TMC5 transmembrane channel-like 5
TMEM212 transmembrane protein 212
TMEM8A transmembrane protein 8A
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAF5 TNF receptor-associated factor 5
TSC22D4 TSC22 domain family, member 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP6 ubiquitin specific peptidase 6
VEZT vezatin, adherens junctions transmembrane protein
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF253 zinc finger protein 253
ZNF324 zinc finger protein 324
ZNF862 zinc finger protein 862