islet cell tumor Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A pancreatic cancer that is located_in the pancreatic islet cells. (Human Disease Ontology, DOID_1799)
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Genes

286 genes co-occuring with the disease islet cell tumor in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INS insulin 2.54238
SST somatostatin 2.14073
MEN1 multiple endocrine neoplasia I 2.07715
GCG glucagon 2.02929
GAST gastrin 1.85364
IAPP islet amyloid polypeptide 1.61307
PPY pancreatic polypeptide 1.58403
IGF2 insulin-like growth factor 2 1.5348
CHGA chromogranin A 1.44913
NIT1 nitrilase 1 1.43025
PTPRN protein tyrosine phosphatase, receptor type, N 1.32716
RPS15 ribosomal protein S15 1.32498
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 1.31056
FOXM1 forkhead box M1 1.29702
GLP1R glucagon-like peptide 1 receptor 1.28348
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.18195
GCK glucokinase (hexokinase 4) 1.15027
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.1439
CPE carboxypeptidase E 1.11351
INSR insulin receptor 1.07908
PDX1 pancreatic and duodenal homeobox 1 1.05177
VIP vasoactive intestinal peptide 1.01976
IGF1 insulin-like growth factor 1 (somatomedin C) 1.01891
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.01765
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 1.01723
POMC proopiomelanocortin 1.0071
CALCA calcitonin-related polypeptide alpha 1.00077
FFAR1 free fatty acid receptor 1 0.912668
GIP gastric inhibitory polypeptide 0.90321
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.88434
ENO2 enolase 2 (gamma, neuronal) 0.881062
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.875738
MRPS31 mitochondrial ribosomal protein S31 0.875329
NRXN2 neurexin 2 0.873281
SCGN secretagogin, EF-hand calcium binding protein 0.855677
CBLN3 cerebellin 3 precursor 0.838476
G6PC2 glucose-6-phosphatase, catalytic, 2 0.800744
SYP synaptophysin 0.797872
IGFBP3 insulin-like growth factor binding protein 3 0.794591
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.791311
MAN1A1 mannosidase, alpha, class 1A, member 1 0.788033
HMX1 H6 family homeobox 1 0.759008
SSTR1 somatostatin receptor 1 0.756564
SSTR5 somatostatin receptor 5 0.735433
GJA4 gap junction protein, alpha 4, 37kDa 0.733001
IL1B interleukin 1, beta 0.727333
SYT4 synaptotagmin IV 0.71925
GHRH growth hormone releasing hormone 0.71925
SLC30A10 solute carrier family 30, member 10 0.714005
PCIF1 PDX1 C-terminal inhibiting factor 1 0.707559
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.700722
SSTR2 somatostatin receptor 2 0.691094
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.684692
ICA1 islet cell autoantigen 1, 69kDa 0.66755
REM2 RAS (RAD and GEM)-like GTP binding 2 0.661594
PAX4 paired box 4 0.65763
MACROD1 MACRO domain containing 1 0.649323
ZGLP1 zinc finger, GATA-like protein 1 0.643009
SYN1 synapsin I 0.639857
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.633563
CBLN4 cerebellin 4 precursor 0.633563
RNF175 ring finger protein 175 0.630027
FIGNL1 fidgetin-like 1 0.621008
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.613965
CALCB calcitonin-related polypeptide beta 0.60342
VGF VGF nerve growth factor inducible 0.6003
SYT7 synaptotagmin VII 0.594064
PTH parathyroid hormone 0.591337
RPS21 ribosomal protein S21 0.58939
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.587833
SNED1 sushi, nidogen and EGF-like domains 1 0.586276
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.58005
INSM1 insulinoma-associated 1 0.57655
RAB3A RAB3A, member RAS oncogene family 0.566831
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.563335
IRS2 insulin receptor substrate 2 0.554791
SYT3 synaptotagmin III 0.547807
TMEM27 transmembrane protein 27 0.547419
NSF N-ethylmaleimide-sensitive factor 0.545093
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.540829
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.538893
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.538506
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.532314
PTHLH parathyroid hormone-like hormone 0.531154
SSTR4 somatostatin receptor 4 0.529608
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.529222
UPK2 uroplakin 2 0.520731
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.519961
CPA6 carboxypeptidase A6 0.512648
HADH hydroxyacyl-CoA dehydrogenase 0.510728
NPY neuropeptide Y 0.509192
EPHA3 EPH receptor A3 0.50689
DDIT3 DNA-damage-inducible transcript 3 0.50689
FOXO1 forkhead box O1 0.505739
TXLNG taxilin gamma 0.500761
NEUROD1 neuronal differentiation 1 0.500379
NACA3P NACA family member 3 pseudogene 0.499997
GAL galanin/GMAP prepropeptide 0.489691
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.489691
CHGB chromogranin B 0.485885
FURIN furin (paired basic amino acid cleaving enzyme) 0.483604
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 0.479427
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.479047
HNF1A HNF1 homeobox A 0.479047
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.476772
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.476393
SSTR3 somatostatin receptor 3 0.470332
SPINK1 serine peptidase inhibitor, Kazal type 1 0.469954
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.466928
CSH2 chorionic somatomammotropin hormone 2 0.458996
STC1 stanniocalcin 1 0.458241
PKM pyruvate kinase, muscle 0.454093
S100A11 S100 calcium binding protein A11 0.451831
VSX1 visual system homeobox 1 0.451454
GLUD1 glutamate dehydrogenase 1 0.450324
CPB1 carboxypeptidase B1 (tissue) 0.447311
PKLR pyruvate kinase, liver and RBC 0.446935
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.4443
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.442042
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.440538
IGFBP6 insulin-like growth factor binding protein 6 0.436402
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.434148
SOX6 SRY (sex determining region Y)-box 6 0.43227
SV2C synaptic vesicle glycoprotein 2C 0.431894
HMGN2 high mobility group nucleosomal binding domain 2 0.431519
ERN1 endoplasmic reticulum to nucleus signaling 1 0.428516
PGPEP1 pyroglutamyl-peptidase I 0.42739
UPK3A uroplakin 3A 0.423265
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.42289
SNAP23 synaptosomal-associated protein, 23kDa 0.422515
DLL1 delta-like 1 (Drosophila) 0.416896
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.408666
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.407919
TSC2 tuberous sclerosis 2 0.403438
SHB Src homology 2 domain containing adaptor protein B 0.398962
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.392629
GRP gastrin-releasing peptide 0.392629
CCNB2 cyclin B2 0.391885
GJD2 gap junction protein, delta 2, 36kDa 0.389281
HIF3A hypoxia inducible factor 3, alpha subunit 0.387423
PCSK1 proprotein convertase subtilisin/kexin type 1 0.384822
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.373328
CBLN1 cerebellin 1 precursor 0.373328
SV2B synaptic vesicle glycoprotein 2B 0.371107
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.369258
BTC betacellulin 0.363716
PRL prolactin 0.353763
SYT1 synaptotagmin I 0.352291
SNX19 sorting nexin 19 0.349349
FOXA2 forkhead box A2 0.339073
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.321909
NPS neuropeptide S 0.319363
ISL1 ISL LIM homeobox 1 0.318999
STYX serine/threonine/tyrosine interacting protein 0.312102
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.304142
DEK DEK proto-oncogene 0.303781
GHSR growth hormone secretagogue receptor 0.303059
NCL nucleolin 0.301254
S100A6 S100 calcium binding protein A6 0.300173
CASR calcium-sensing receptor 0.299452
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.298371
SCG5 secretogranin V 0.298371
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.295132
PC pyruvate carboxylase 0.294413
CCK cholecystokinin 0.294413
POU2F2 POU class 2 homeobox 2 0.292616
PRDM2 PR domain containing 2, with ZNF domain 0.291539
HK1 hexokinase 1 0.289386
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.289386
IGFBP1 insulin-like growth factor binding protein 1 0.28831
NKX2-2 NK2 homeobox 2 0.284371
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.281153
IRF1 interferon regulatory factor 1 0.27687
NPTX1 neuronal pentraxin I 0.276514
ADM adrenomedullin 0.275089
ITGA6 integrin, alpha 6 0.270464
LRRC25 leucine rich repeat containing 25 0.269043
AFP alpha-fetoprotein 0.269043
DNAH8 dynein, axonemal, heavy chain 8 0.267622
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.259477
FAM3B family with sequence similarity 3, member B 0.257005
NF1 neurofibromin 1 0.256299
CALB1 calbindin 1, 28kDa 0.254183
SCG3 secretogranin III 0.253127
LAMB2 laminin, beta 2 (laminin S) 0.252422
JUN jun proto-oncogene 0.251718
LUZP4 leucine zipper protein 4 0.249608
MAPK8 mitogen-activated protein kinase 8 0.247501
NPY2R neuropeptide Y receptor Y2 0.242595
SOCS6 suppressor of cytokine signaling 6 0.241196
GCGR glucagon receptor 0.239799
SV2A synaptic vesicle glycoprotein 2A 0.239101
ELOVL5 ELOVL fatty acid elongase 5 0.237009
NCK1 NCK adaptor protein 1 0.237009
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.23666
NKX6-1 NK6 homeobox 1 0.231795
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.230755
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.229716
SNAPIN SNAP-associated protein 0.229024
PIDD1 p53-induced death domain protein 1 0.228333
MADD MAP-kinase activating death domain 0.228333
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.224196
LHX2 LIM homeobox 2 0.223509
CEL carboxyl ester lipase 0.221793
ATF4 activating transcription factor 4 0.221108
LATS1 large tumor suppressor kinase 1 0.221108
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.220766
ADCY2 adenylate cyclase 2 (brain) 0.217012
GJA1 gap junction protein, alpha 1, 43kDa 0.215992
MEIS2 Meis homeobox 2 0.212945
RAB2A RAB2A, member RAS oncogene family 0.211597
UBE2I ubiquitin-conjugating enzyme E2I 0.207578
CD164 CD164 molecule, sialomucin 0.202618
ZNF79 zinc finger protein 79 0.201962
CELA1 chymotrypsin-like elastase family, member 1 0.199681
MNX1 motor neuron and pancreas homeobox 1 0.199681
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.196459
CSN2 casein beta 0.196139
NLRP2 NLR family, pyrin domain containing 2 0.194865
FST follistatin 0.193285
CELA3B chymotrypsin-like elastase family, member 3B 0.191408
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.189551
AMY2A amylase, alpha 2A (pancreatic) 0.189551
STX1A syntaxin 1A (brain) 0.184128
HSPH1 heat shock 105kDa/110kDa protein 1 0.181798
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.180937
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.180367
EPHA2 EPH receptor A2 0.179239
HES6 hes family bHLH transcription factor 6 0.179239
FOS FBJ murine osteosarcoma viral oncogene homolog 0.179239
RXRG retinoid X receptor, gamma 0.17896
CHN2 chimerin 2 0.177301
RIMS1 regulating synaptic membrane exocytosis 1 0.174881
RET ret proto-oncogene 0.173571
CASC5 cancer susceptibility candidate 5 0.173314
CCKBR cholecystokinin B receptor 0.171286
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.170544
DPP4 dipeptidyl-peptidase 4 0.170544
POU2F1 POU class 2 homeobox 1 0.169812
ACTN2 actinin, alpha 2 0.16933
SPOP speckle-type POZ protein 0.167224
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.166995
HMBS hydroxymethylbilane synthase 0.166768
PIP prolactin-induced protein 0.165435
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.165217
NCAM1 neural cell adhesion molecule 1 0.164786
GAN gigaxonin 0.162707
PTPRD protein tyrosine phosphatase, receptor type, D 0.161716
GK glycerol kinase 0.161331
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.160948
AK2 adenylate kinase 2 0.158605
HRH2 histamine receptor H2 0.157929
VEGFA vascular endothelial growth factor A 0.157929
PTF1A pancreas specific transcription factor, 1a 0.143531
SOX17 SRY (sex determining region Y)-box 17 0.142823
SOX2 SRY (sex determining region Y)-box 2 0.137842
GHRL ghrelin/obestatin prepropeptide 0.134177
PYGM phosphorylase, glycogen, muscle 0.126475
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119323
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.115567
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.114767
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.114687
ATXN10 ataxin 10 0.114563
SMS spermine synthase 0.114563
PAX8 paired box 8 0.114026
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.113564
TXNIP thioredoxin interacting protein 0.113351
VAMP8 vesicle-associated membrane protein 8 0.113308
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.113138
SYN2 synapsin II 0.113053
PDE8B phosphodiesterase 8B 0.112706
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.112179
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.111777
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.111732
DIABLO diablo, IAP-binding mitochondrial protein 0.111687
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.111597
GRPR gastrin-releasing peptide receptor 0.111506
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.111461
LEP leptin 0.11128
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.110635
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.11031
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.110263
FFAR4 free fatty acid receptor 4 0.109933
PAX6 paired box 6 0.109742
GLIS3 GLIS family zinc finger 3 0.109694
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.109455