ischemic bone disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone disease that results_in an interruption of blood supply located_in bone. (Human Disease Ontology, DOID_0080008)
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Genes

303 genes co-occuring with the disease ischemic bone disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BMP2 bone morphogenetic protein 2 1.49964
BGLAP bone gamma-carboxyglutamate (gla) protein 1.45616
ALPPL2 alkaline phosphatase, placental-like 2 1.28566
ALPP alkaline phosphatase, placental 1.28523
ALPL alkaline phosphatase, liver/bone/kidney 1.28435
F5 coagulation factor V (proaccelerin, labile factor) 1.26386
RUNX2 runt-related transcription factor 2 1.25341
ACAN aggrecan 1.18496
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.15837
COL2A1 collagen, type II, alpha 1 1.11982
PTH parathyroid hormone 1.10846
PROS1 protein S (alpha) 1.09461
AMIGO2 adhesion molecule with Ig-like domain 2 1.09377
ZNF461 zinc finger protein 461 1.02903
ZNF28 zinc finger protein 28 1.02903
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.02187
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.01934
GBA glucosidase, beta, acid 1.01765
NCDN neurochondrin 1.01554
F2 coagulation factor II (thrombin) 0.987693
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 0.979689
BMP7 bone morphogenetic protein 7 0.976323
NOTCH1 notch 1 0.976323
PLG plasminogen 0.973801
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.97212
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.97128
VEGFA vascular endothelial growth factor A 0.960797
EGFL6 EGF-like-domain, multiple 6 0.953273
IHH indian hedgehog 0.922149
COL9A3 collagen, type IX, alpha 3 0.882292
ZNF71 zinc finger protein 71 0.876148
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.862228
DLK2 delta-like 2 homolog (Drosophila) 0.854859
SCAND1 SCAN domain containing 1 0.853631
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 0.831099
GPR26 G protein-coupled receptor 26 0.823308
XIRP2 xin actin binding repeat containing 2 0.822897
SOST sclerostin 0.805667
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.795821
CBY3 chibby homolog 3 (Drosophila) 0.791311
CALCA calcitonin-related polypeptide alpha 0.790492
EGFL8 EGF-like-domain, multiple 8 0.783936
FDPS farnesyl diphosphate synthase 0.780251
COL9A2 collagen, type IX, alpha 2 0.779432
PLAT plasminogen activator, tissue 0.750864
RBMS3 RNA binding motif, single stranded interacting protein 3 0.730976
MMP13 matrix metallopeptidase 13 0.708364
ACPP acid phosphatase, prostate 0.703938
RBBP9 retinoblastoma binding protein 9 0.703536
SMR3A submaxillary gland androgen regulated protein 3A 0.701928
PPARG peroxisome proliferator-activated receptor gamma 0.696306
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.688291
COMP cartilage oligomeric matrix protein 0.686291
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.685491
PRR20C proline rich 20C 0.67113
PRR20E proline rich 20E 0.67113
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.66596
IGF1 insulin-like growth factor 1 (somatomedin C) 0.660008
PTH2R parathyroid hormone 2 receptor 0.653671
PRR20A proline rich 20A 0.648533
WRNIP1 Werner helicase interacting protein 1 0.645375
DNTT DNA nucleotidylexotransferase 0.637889
P3H2 prolyl 3-hydroxylase 2 0.605372
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.59913
COL9A1 collagen, type IX, alpha 1 0.581996
COL1A1 collagen, type I, alpha 1 0.581217
C4BPA complement component 4 binding protein, alpha 0.574217
PLAC8 placenta-specific 8 0.567609
CLCN2 chloride channel, voltage-sensitive 2 0.563335
WNT3A wingless-type MMTV integration site family, member 3A 0.553239
SOX9 SRY (sex determining region Y)-box 9 0.550911
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.549359
F3 coagulation factor III (thromboplastin, tissue factor) 0.520731
CD4 CD4 molecule 0.51919
CTSK cathepsin K 0.518805
SP7 Sp7 transcription factor 0.508808
MSLNL mesothelin-like 0.507273
PHIP pleckstrin homology domain interacting protein 0.487788
SMAD7 SMAD family member 7 0.486646
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.486266
NARF nuclear prelamin A recognition factor 0.485505
AOAH acyloxyacyl hydrolase (neutrophil) 0.485505
MSX1 msh homeobox 1 0.481325
TPRG1L tumor protein p63 regulated 1-like 0.480186
ASRGL1 asparaginase like 1 0.476014
POSTN periostin, osteoblast specific factor 0.475634
FAM120A family with sequence similarity 120A 0.472604
VWF von Willebrand factor 0.468441
EHF ets homologous factor 0.462016
SON SON DNA binding protein 0.448441
LAX1 lymphocyte transmembrane adaptor 1 0.44129
MMP3 matrix metallopeptidase 3 0.440538
TBX5 T-box 5 0.434524
LRP5 low density lipoprotein receptor-related protein 5 0.431144
F8 coagulation factor VIII, procoagulant component 0.429266
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.428891
CHIT1 chitinase 1 (chitotriosidase) 0.417644
CRP C-reactive protein, pentraxin-related 0.41727
HBD hemoglobin, delta 0.416147
C1QC complement component 1, q subcomponent, C chain 0.412405
ACTG2 actin, gamma 2, smooth muscle, enteric 0.408292
APOB apolipoprotein B 0.407919
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.403438
MYDGF myeloid-derived growth factor 0.397843
PON1 paraoxonase 1 0.393374
MATR3 matrin 3 0.392257
ACP5 acid phosphatase 5, tartrate resistant 0.386308
FAF1 Fas (TNFRSF6) associated factor 1 0.369997
TNR tenascin R 0.365193
ADAM2 ADAM metallopeptidase domain 2 0.364824
ELOVL2 ELOVL fatty acid elongase 2 0.364454
ERCC8 excision repair cross-complementation group 8 0.362239
STRADA STE20-related kinase adaptor alpha 0.360764
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.358183
IL1B interleukin 1, beta 0.357814
PAX1 paired box 1 0.353763
PGRMC1 progesterone receptor membrane component 1 0.351555
SIK1 salt-inducible kinase 1 0.350084
FBL fibrillarin 0.348614
IL33 interleukin 33 0.343106
ANXA2 annexin A2 0.343106
CUL4B cullin 4B 0.342739
TGFB1 transforming growth factor, beta 1 0.342372
CCDC34 coiled-coil domain containing 34 0.333218
TLR4 toll-like receptor 4 0.330295
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.325187
HBB hemoglobin, beta 0.323002
OGN osteoglycin 0.320454
RER1 retention in endoplasmic reticulum sorting receptor 1 0.320454
NELL1 NEL-like 1 (chicken) 0.317909
ESR1 estrogen receptor 1 0.317545
GH1 growth hormone 1 0.316092
HBA2 hemoglobin, alpha 2 0.312827
TBX1 T-box 1 0.311014
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.303059
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.298731
VEGFC vascular endothelial growth factor C 0.295851
DPYS dihydropyrimidinase 0.295492
GP9 glycoprotein IX (platelet) 0.295492
FBLL1 fibrillarin-like 1 0.295132
BMP6 bone morphogenetic protein 6 0.292616
IL17A interleukin 17A 0.292257
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.289386
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.289027
SREBF2 sterol regulatory element binding transcription factor 2 0.281153
TIMP1 TIMP metallopeptidase inhibitor 1 0.278654
BIN2 bridging integrator 2 0.27794
NCOA2 nuclear receptor coactivator 2 0.277584
NOS3 nitric oxide synthase 3 (endothelial cell) 0.277584
NPPC natriuretic peptide C 0.275089
HBG2 hemoglobin, gamma G 0.274021
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.273664
APOA1 apolipoprotein A-I 0.272953
FBLN2 fibulin 2 0.270464
HBA1 hemoglobin, alpha 1 0.264431
A1BG alpha-1-B glycoprotein 0.264077
BMP4 bone morphogenetic protein 4 0.263722
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.263368
IL31RA interleukin 31 receptor A 0.25983
STAG2 stromal antigen 2 0.258417
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.256299
C4B complement component 4B (Chido blood group) 0.255241
COL5A2 collagen, type V, alpha 2 0.254888
IVD isovaleryl-CoA dehydrogenase 0.254888
EGFL7 EGF-like-domain, multiple 7 0.251015
EPHB1 EPH receptor B1 0.24996
PRKCD protein kinase C, delta 0.248905
PDGFB platelet-derived growth factor beta polypeptide 0.248554
FGF2 fibroblast growth factor 2 (basic) 0.246448
OCM2 oncomodulin 2 0.244345
ANXA5 annexin A5 0.242945
TLK2 tousled-like kinase 2 0.237357
PTCH2 patched 2 0.231795
OCM oncomodulin 0.227642
DCSTAMP dendrocyte expressed seven transmembrane protein 0.21974
CD34 CD34 molecule 0.218034
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.218034
HAT1 histone acetyltransferase 1 0.217693
C1QB complement component 1, q subcomponent, B chain 0.217012
DSG1 desmoglein 1 0.214297
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.210925
METTL13 methyltransferase like 13 0.208579
THBD thrombomodulin 0.208579
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.202946
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.200656
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.199681
WNT3 wingless-type MMTV integration site family, member 3 0.197099
CCL5 chemokine (C-C motif) ligand 5 0.190786
ANXA6 annexin A6 0.188022
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.185016
MMD monocyte to macrophage differentiation-associated 0.183835
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.180937
PTHLH parathyroid hormone-like hormone 0.180937
SATB2 SATB homeobox 2 0.17896
LOX lysyl oxidase 0.178682
TAC1 tachykinin, precursor 1 0.178682
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 0.177576
HYOU1 hypoxia up-regulated 1 0.171535
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.170544
CP ceruloplasmin (ferroxidase) 0.169812
MMP8 matrix metallopeptidase 8 0.169091
WDFY2 WD repeat and FYVE domain containing 2 0.168617
CALCOCO2 calcium binding and coiled-coil domain 2 0.167452
ULK1 unc-51 like autophagy activating kinase 1 0.166319
DLX5 distal-less homeobox 5 0.164149
MMP9 matrix metallopeptidase 9 0.163729
CNR2 cannabinoid receptor 2 (macrophage) 0.161523
TNF tumor necrosis factor 0.161523
CXCL12 chemokine (C-X-C motif) ligand 12 0.160948
MYD88 myeloid differentiation primary response 88 0.15948
ACP1 acid phosphatase 1, soluble 0.159302
ALB albumin 0.158951
TRPS1 trichorhinophalangeal syndrome I 0.158951
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.144112
PPT1 palmitoyl-protein thioesterase 1 0.143617
COL6A1 collagen, type VI, alpha 1 0.143169
LUM lumican 0.142558
PEPD peptidase D 0.142551
HSF4 heat shock transcription factor 4 0.142403
VCAN versican 0.141411
EXT1 exostosin glycosyltransferase 1 0.14068
IFI44L interferon-induced protein 44-like 0.1391
FBLN1 fibulin 1 0.136451
ACOT13 acyl-CoA thioesterase 13 0.135744
MATN3 matrilin 3 0.135081
BMPR1A bone morphogenetic protein receptor, type IA 0.133781
UNG uracil-DNA glycosylase 0.133639
C5AR1 complement component 5a receptor 1 0.131159
FRY furry homolog (Drosophila) 0.130583
COL10A1 collagen, type X, alpha 1 0.130318
PDE4B phosphodiesterase 4B, cAMP-specific 0.130275
COL1A2 collagen, type I, alpha 2 0.130161
GJA5 gap junction protein, alpha 5, 40kDa 0.130089
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.129097
EPHA4 EPH receptor A4 0.129066
NPTXR neuronal pentraxin receptor 0.12905
WISP3 WNT1 inducible signaling pathway protein 3 0.128153
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.128069
MCM8 minichromosome maintenance complex component 8 0.12744
BAK1 BCL2-antagonist/killer 1 0.127208
FMOD fibromodulin 0.127041
ASPN asporin 0.126383
IRF6 interferon regulatory factor 6 0.125873
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.123848
TGFBR1 transforming growth factor, beta receptor 1 0.12378
HPR haptoglobin-related protein 0.12334
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.12327
UBC ubiquitin C 0.123247
RPS27A ribosomal protein S27a 0.122696
PTH1R parathyroid hormone 1 receptor 0.122427
MEF2C myocyte enhancer factor 2C 0.122352
ANGPTL4 angiopoietin-like 4 0.121929
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.121929
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.121517
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.120779
FBN1 fibrillin 1 0.120645
GLI3 GLI family zinc finger 3 0.119814
FGFR3 fibroblast growth factor receptor 3 0.119701
UBB ubiquitin B 0.119417
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.118539
RNASEH2A ribonuclease H2, subunit A 0.118508
NCOA1 nuclear receptor coactivator 1 0.118418
CD59 CD59 molecule, complement regulatory protein 0.116768
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.116149
CTGF connective tissue growth factor 0.115616
LEF1 lymphoid enhancer-binding factor 1 0.115483
CD44 CD44 molecule (Indian blood group) 0.114587
PFN2 profilin 2 0.114516
CTSB cathepsin B 0.113187
SMAD3 SMAD family member 3 0.112931
PRRC2A proline-rich coiled-coil 2A 0.112141
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.111681
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.111332
NOG noggin 0.110022
MPO myeloperoxidase 0.108361
MMP2 matrix metallopeptidase 2 0.107503
SMO smoothened, frizzled class receptor 0.107329
ZFPM1 zinc finger protein, FOG family member 1 0.106982
F10 coagulation factor X 0.106848
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.106002
SIX2 SIX homeobox 2 0.105685
TGFBI transforming growth factor, beta-induced, 68kDa 0.105502
FGF7 fibroblast growth factor 7 0.105502
RAP1A RAP1A, member of RAS oncogene family 0.105319
WNT10B wingless-type MMTV integration site family, member 10B 0.105136
APAF1 apoptotic peptidase activating factor 1 0.104999
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.104908
HP haptoglobin 0.104817
CCL4 chemokine (C-C motif) ligand 4 0.104676
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.104489
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.104442
FHL1 four and a half LIM domains 1 0.104301
PTCH1 patched 1 0.10416
F9 coagulation factor IX 0.104067
SCG2 secretogranin II 0.103973
LARS leucyl-tRNA synthetase 0.103879
IL23R interleukin 23 receptor 0.103549
EPHB3 EPH receptor B3 0.103164
SEPT4 septin 4 0.103116
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.102492
RNF112 ring finger protein 112 0.102147
WDR11 WD repeat domain 11 0.101999
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.101802