ischemia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. (Experimental Factor Ontology, EFO_0000556)
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Genes

243 genes co-occuring with the biological term ischemia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA2B adrenoceptor alpha 2B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALB albumin
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
ANXA5 annexin A5
ANXA7 annexin A7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARG1 arginase 1
ASIC1 acid sensing (proton gated) ion channel 1
ASIC3 acid sensing (proton gated) ion channel 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AXL AXL receptor tyrosine kinase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BMX BMX non-receptor tyrosine kinase
C3 complement component 3
C5 complement component 5
CALCA calcitonin-related polypeptide alpha
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CARTPT CART prepropeptide
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCR2 chemokine (C-C motif) receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFH complement factor H
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CSN3 casein kappa
CST3 cystatin C
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYGB cytoglobin
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DLG4 discs, large homolog 4 (Drosophila)
E2F3 E2F transcription factor 3
EDN1 endothelin 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
ESRRA estrogen-related receptor alpha
ESRRG estrogen-related receptor gamma
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF1 fibroblast growth factor 1 (acidic)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS6 growth arrest-specific 6
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GP6 glycoprotein VI (platelet)
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRM1 glutamate receptor, metabotropic 1
HAMP hepcidin antimicrobial peptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HRH1 histamine receptor H1
HRH2 histamine receptor H2
HRH3 histamine receptor H3
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL12A interleukin 12A
IL32 interleukin 32
IL6 interleukin 6
IRF2BP2 interferon regulatory factor 2 binding protein 2
ITGAV integrin, alpha V
ITLN1 intelectin 1 (galactofuranose binding)
JAK2 Janus kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLK1 kallikrein 1
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LEP leptin
LGMN legumain
MAG myelin associated glycoprotein
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MDK midkine (neurite growth-promoting factor 2)
MFGE8 milk fat globule-EGF factor 8 protein
MIR16-1 microRNA 16-1
MIR210 microRNA 210
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAMPT nicotinamide phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NPPB natriuretic peptide B
NRG1 neuregulin 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OTUD7B OTU deubiquitinase 7B
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PANX1 pannexin 1
PARP1 poly (ADP-ribose) polymerase 1
PER2 period circadian clock 2
PGF placental growth factor
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAT plasminogen activator, tissue
PNOC prepronociceptin
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PRNP prion protein
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTBP1 polypyrimidine tract binding protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RETN resistin
RPL13A ribosomal protein L13a
RUNX1 runt-related transcription factor 1
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCUBE1 signal peptide, CUB domain, EGF-like 1
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHH sonic hedgehog
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TAC1 tachykinin, precursor 1
TF transferrin
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
THBS1 thrombospondin 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM1 triggering receptor expressed on myeloid cells 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TXN thioredoxin
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XDH xanthine dehydrogenase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1