iris synechia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an adhesion (synechia) of the iris to the cornea or lens of the eye that may develop from glaucoma, cataracts, uveitis, or keratitis or as a complication of surgery or trauma to the eye; synechiae may prevent or impede flow of aqueous fluid between the anterior and posterior chambers of the eye, resulting in angle closure glaucoma (Mammalian Phenotype Ontology, MP_0004222)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004222
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Genes

21 gene mutations causing the iris synechia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
BCAR3 breast cancer anti-estrogen resistance 3
BMP4 bone morphogenetic protein 4
CENPJ centromere protein J
COL4A1 collagen, type IV, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FGF10 fibroblast growth factor 10
FOXC1 forkhead box C1
FOXE3 forkhead box E3
FOXF2 forkhead box F2
GSK3A glycogen synthase kinase 3 alpha
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMX1B LIM homeobox transcription factor 1, beta
MSX2 msh homeobox 2
PAX6 paired box 6
PEX3 peroxisomal biogenesis factor 3
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
SH3PXD2B SH3 and PX domains 2B
SIRT1 sirtuin 1
VAV2 vav 2 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1