iris disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

225 genes co-occuring with the disease iris disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PAX6 paired box 6 3.22842
LOXL1 lysyl oxidase-like 1 2.60351
WT1 Wilms tumor 1 1.79616
PEX19 peroxisomal biogenesis factor 19 1.68861
FSHB follicle stimulating hormone, beta polypeptide 1.6651
ELP4 elongator acetyltransferase complex subunit 4 1.44254
MPPED2 metallophosphoesterase domain containing 2 1.36509
DCDC1 doublecortin domain containing 1 1.30532
PITX2 paired-like homeodomain 2 1.29483
GPNMB glycoprotein (transmembrane) nmb 1.24298
FOXC1 forkhead box C1 1.20569
CAT catalase 1.1588
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 1.13755
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 1.13755
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1.06732
CCDC167 coiled-coil domain containing 167 1.05934
TBC1D21 TBC1 domain family, member 21 1.05934
TYRP1 tyrosinase-related protein 1 1.04924
FBN1 fibrillin 1 0.986428
FOXE3 forkhead box E3 0.97086
LYST lysosomal trafficking regulator 0.966244
TMEM9 transmembrane protein 9 0.954525
MRAP melanocortin 2 receptor accessory protein 0.937044
VSX2 visual system homeobox 2 0.93207
LUZP2 leucine zipper protein 2 0.925452
CNTNAP2 contactin associated protein-like 2 0.919673
ADRA1D adrenoceptor alpha 1D 0.91308
LOX lysyl oxidase 0.911433
SLC38A8 solute carrier family 38, member 8 0.90732
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.888438
MGST1 microsomal glutathione S-transferase 1 0.869187
STMN4 stathmin-like 4 0.851583
LTBP3 latent transforming growth factor beta binding protein 3 0.848716
LTBP1 latent transforming growth factor beta binding protein 1 0.843802
SRP72 signal recognition particle 72kDa 0.843802
PAX1 paired box 1 0.818385
B3GAT1 beta-1,3-glucuronyltransferase 1 0.815514
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.81018
LTBP2 latent transforming growth factor beta binding protein 2 0.808949
SIX3 SIX homeobox 3 0.805257
PAX2 paired box 2 0.800333
CTNNBL1 catenin, beta like 1 0.740299
FBLN2 fibulin 2 0.706351
PITX3 paired-like homeodomain 3 0.67551
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.675112
ACP2 acid phosphatase 2, lysosomal 0.66199
SIX6 SIX homeobox 6 0.6214
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.604201
ADRA1A adrenoceptor alpha 1A 0.594843
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.594454
NR2E1 nuclear receptor subfamily 2, group E, member 1 0.590558
GSC2 goosecoid homeobox 2 0.582384
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.578883
KRT3 keratin 3, type II 0.57305
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.572662
PTER phosphotriesterase related 0.572273
WDR36 WD repeat domain 36 0.567609
ACP1 acid phosphatase 1, soluble 0.564889
GGT2 gamma-glutamyltransferase 2 0.5645
MFAP2 microfibrillar-associated protein 2 0.562558
TGFB2 transforming growth factor, beta 2 0.556732
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.524588
KDM2B lysine (K)-specific demethylase 2B 0.516879
IRX6 iroquois homeobox 6 0.507657
PAX3 paired box 3 0.50689
EHD1 EH-domain containing 1 0.506507
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.504973
B3GALTL beta 1,3-galactosyltransferase-like 0.499231
PHB2 prohibitin 2 0.497321
GAS2 growth arrest-specific 2 0.493122
EMX1 empty spiracles homeobox 1 0.491215
TIMP2 TIMP metallopeptidase inhibitor 2 0.487027
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.484364
IGF2 insulin-like growth factor 2 0.471846
PAX4 paired box 4 0.469197
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.46466
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.464283
PHGDH phosphoglycerate dehydrogenase 0.461261
ELN elastin 0.460506
HLA-C major histocompatibility complex, class I, C 0.458619
OTX2 orthodenticle homeobox 2 0.456732
MNX1 motor neuron and pancreas homeobox 1 0.456355
KLK15 kallikrein-related peptidase 15 0.448064
OPTN optineurin 0.4443
CD151 CD151 molecule (Raph blood group) 0.440538
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.437154
IRX3 iroquois homeobox 3 0.433021
DLX1 distal-less homeobox 1 0.42364
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.417644
CNOT1 CCR4-NOT transcription complex, subunit 1 0.415773
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.406798
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.400826
CRYBA4 crystallin, beta A4 0.394863
OTX1 orthodenticle homeobox 1 0.391885
SEBOX SEBOX homeobox 0.388909
SDC3 syndecan 3 0.388538
AK2 adenylate kinase 2 0.380368
LDHA lactate dehydrogenase A 0.377402
NDP Norrie disease (pseudoglioma) 0.375179
GPR143 G protein-coupled receptor 143 0.372217
BDNF brain-derived neurotrophic factor 0.363347
AKAP2 A kinase (PRKA) anchor protein 2 0.352659
CRYAA crystallin, alpha A 0.348981
GGT1 gamma-glutamyltransferase 1 0.348981
TIMP1 TIMP metallopeptidase inhibitor 1 0.341639
BFSP2 beaded filament structural protein 2, phakinin 0.337975
TUBGCP4 tubulin, gamma complex associated protein 4 0.336876
CTGF connective tissue growth factor 0.331756
EYS eyes shut homolog (Drosophila) 0.328834
MMP2 matrix metallopeptidase 2 0.326281
MT-ATP8 ATP synthase F0 subunit 8 0.319726
PIDD1 p53-induced death domain protein 1 0.315003
KRT12 keratin 12, type I 0.30848
LOXL2 lysyl oxidase-like 2 0.300173
GDF6 growth differentiation factor 6 0.299452
WNT7B wingless-type MMTV integration site family, member 7B 0.295851
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.292257
LATS1 large tumor suppressor kinase 1 0.292257
NDEL1 nudE neurodevelopment protein 1-like 1 0.290103
ALX4 ALX homeobox 4 0.280439
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.273308
PADI2 peptidyl arginine deiminase, type II 0.272597
TGFB1 transforming growth factor, beta 1 0.270108
CARD8 caspase recruitment domain family, member 8 0.269753
POU3F4 POU class 3 homeobox 4 0.269753
MPG N-methylpurine-DNA glycosylase 0.259477
VCAN versican 0.243995
MMP1 matrix metallopeptidase 1 0.242595
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.233183
KIF21A kinesin family member 21A 0.226952
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.225573
HESX1 HESX homeobox 1 0.214636
SOD2 superoxide dismutase 2, mitochondrial 0.212945
CRYBB2 crystallin, beta B2 0.204593
DSC2 desmocollin 2 0.201962
POU4F1 POU class 4 homeobox 1 0.199681
ALB albumin 0.198386
SOX1 SRY (sex determining region Y)-box 1 0.197742
MGAT4C MGAT4 family, member C 0.197099
NEUROD1 neuronal differentiation 1 0.19582
EYA1 EYA transcriptional coactivator and phosphatase 1 0.194548
SZRD1 SUZ RNA binding domain containing 1 0.185313
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.179239
PAX5 paired box 5 0.177029
FOXD3 forkhead box D3 0.176215
HGFAC HGF activator 0.174354
PAX9 paired box 9 0.173057
TYR tyrosinase 0.172291
CRYAB crystallin, alpha B 0.165001
CST4 cystatin S 0.164359
MMP9 matrix metallopeptidase 9 0.162505
GSTTP1 glutathione S-transferase theta pseudogene 1 0.160387
GSTT1 glutathione S-transferase theta 1 0.160387
APOE apolipoprotein E 0.160203
HBG2 hemoglobin, gamma G 0.158778
CCND1 cyclin D1 0.13954
NF1 neurofibromin 1 0.130596
PSEN2 presenilin 2 0.127041
SAG S-antigen; retina and pineal gland (arrestin) 0.126894
DEK DEK proto-oncogene 0.123735
CLU clusterin 0.12327
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.122648
TIMP4 TIMP metallopeptidase inhibitor 4 0.121697
HPN hepsin 0.121568
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.120992
CD4 CD4 molecule 0.120806
NOD2 nucleotide-binding oligomerization domain containing 2 0.120288
SIX1 SIX homeobox 1 0.120151
SLPI secretory leukocyte peptidase inhibitor 0.118834
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.118629
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.118296
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.117963
NEB nebulin 0.116832
NID1 nidogen 1 0.116639
HHAT hedgehog acyltransferase 0.11651
FRZB frizzled-related protein 0.116216
BMP4 bone morphogenetic protein 4 0.116216
EXTL3 exostosin-like glycosyltransferase 3 0.116183
EDN1 endothelin 1 0.115849
OCA2 oculocutaneous albinism II 0.115716
PRDX6 peroxiredoxin 6 0.115616
UBE2B ubiquitin-conjugating enzyme E2B 0.114551
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.11448
ACE angiotensin I converting enzyme 0.114232
LAMA3 laminin, alpha 3 0.113984
HLA-A major histocompatibility complex, class I, A 0.113771
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.113077
SOX2 SRY (sex determining region Y)-box 2 0.112968
IL31RA interleukin 31 receptor A 0.112593
DACH1 dachshund family transcription factor 1 0.112367
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.111681
HMOX2 heme oxygenase 2 0.111487
LRP6 low density lipoprotein receptor-related protein 6 0.110861
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.110383
FN1 fibronectin 1 0.110022
GHRL ghrelin/obestatin prepropeptide 0.109899
CSF3 colony stimulating factor 3 (granulocyte) 0.109858
CRLF1 cytokine receptor-like factor 1 0.109817
ESD esterase D 0.109448
CHM choroideremia (Rab escort protein 1) 0.109366
HN1 hematological and neurological expressed 1 0.108952
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.108614
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.108361
COL6A1 collagen, type VI, alpha 1 0.108319
EXT2 exostosin glycosyltransferase 2 0.107719
HPGDS hematopoietic prostaglandin D synthase 0.107633
GSTM1 glutathione S-transferase mu 1 0.107503
HRAS Harvey rat sarcoma viral oncogene homolog 0.107286
CHKA choline kinase alpha 0.107286
CD79A CD79a molecule, immunoglobulin-associated alpha 0.107199
EEF2 eukaryotic translation elongation factor 2 0.106982
CELA1 chymotrypsin-like elastase family, member 1 0.105958
CRX cone-rod homeobox 0.105868
GLS glutaminase 0.105593
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.105456
NTF3 neurotrophin 3 0.105456
CELA3B chymotrypsin-like elastase family, member 3B 0.104723
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.104067
UBE2A ubiquitin-conjugating enzyme E2A 0.103501
HLA-E major histocompatibility complex, class I, E 0.103404
ISL1 ISL LIM homeobox 1 0.102972
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.102876
NLRP3 NLR family, pyrin domain containing 3 0.10254
MMP3 matrix metallopeptidase 3 0.10254
MSX1 msh homeobox 1 0.102492