irinotecan-7530 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the irinotecan-7530 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AOC3 amine oxidase, copper containing 3
ATF3 activating transcription factor 3
ATG12 autophagy related 12
BLNK B-cell linker
BTG2 BTG family, member 2
C11ORF68 chromosome 11 open reading frame 68
C17ORF80 chromosome 17 open reading frame 80
CD83 CD83 molecule
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEL carboxyl ester lipase
CFHR4 complement factor H-related 4
CSF1R colony stimulating factor 1 receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DIEXF digestive organ expansion factor homolog (zebrafish)
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
ECM1 extracellular matrix protein 1
ERCC4 excision repair cross-complementation group 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXL8 F-box and leucine-rich repeat protein 8
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAMT guanidinoacetate N-methyltransferase
GM2A GM2 ganglioside activator
GPR137 G protein-coupled receptor 137
GPR87 G protein-coupled receptor 87
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
HBEGF heparin-binding EGF-like growth factor
HIC2 hypermethylated in cancer 2
HIST1H3B histone cluster 1, H3b
HPX hemopexin
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFT27 intraflagellar transport 27
JAG1 jagged 1
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LEFTY1 left-right determination factor 1
LIF leukemia inhibitory factor
LOC157562 uncharacterized LOC157562
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MR1 major histocompatibility complex, class I-related
MTL5 metallothionein-like 5, testis-specific (tesmin)
MXD4 MAX dimerization protein 4
NFYA nuclear transcription factor Y, alpha
NGDN neuroguidin, EIF4E binding protein
NHLH2 nescient helix loop helix 2
NUP88 nucleoporin 88kDa
NUPR1 nuclear protein, transcriptional regulator, 1
NYNRIN NYN domain and retroviral integrase containing
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PABPN1 poly(A) binding protein, nuclear 1
PARD6B par-6 family cell polarity regulator beta
PDE4A phosphodiesterase 4A, cAMP-specific
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PGF placental growth factor
PIDD1 p53-induced death domain protein 1
PLAU plasminogen activator, urokinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PYGM phosphorylase, glycogen, muscle
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RFPL3S RFPL3 antisense
RNF6 ring finger protein (C3H2C3 type) 6
RSL1D1 ribosomal L1 domain containing 1
RTCA RNA 3'-terminal phosphate cyclase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND2P SCAN domain containing 2 pseudogene
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFN stratifin
SIRT4 sirtuin 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SOCS1 suppressor of cytokine signaling 1
TBL2 transducin (beta)-like 2
TMEM183A transmembrane protein 183A
UCN urocortin
VPREB3 pre-B lymphocyte 3
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF250 zinc finger protein 250
ZNF750 zinc finger protein 750
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACVR1 activin A receptor, type I
ADGRL2 adhesion G protein-coupled receptor L2
AGO2 argonaute RISC catalytic component 2
ANKRD11 ankyrin repeat domain 11
ANKRD28 ankyrin repeat domain 28
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP12 Rho GTPase activating protein 12
ARID5B AT rich interactive domain 5B (MRF1-like)
BMPR1A bone morphogenetic protein receptor, type IA
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C4ORF19 chromosome 4 open reading frame 19
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPE centromere protein E, 312kDa
CLASP1 cytoplasmic linker associated protein 1
DAAM1 dishevelled associated activator of morphogenesis 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND1B DENN/MADD domain containing 1B
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNA4 ephrin-A4
EHBP1 EH domain binding protein 1
ERBB2IP erbb2 interacting protein
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM69A family with sequence similarity 69, member A
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GHR growth hormone receptor
GLCE glucuronic acid epimerase
GRHL2 grainyhead-like 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
GTF2IRD1 GTF2I repeat domain containing 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HJURP Holliday junction recognition protein
HMBOX1 homeobox containing 1
INSIG2 insulin induced gene 2
JARID2 jumonji, AT rich interactive domain 2
JMJD1C jumonji domain containing 1C
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF16B kinesin family member 16B
KIF18A kinesin family member 18A
KIF1B kinesin family member 1B
KIF20B kinesin family member 20B
KIZ kizuna centrosomal protein
KRBOX4 KRAB box domain containing 4
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MCM9 minichromosome maintenance complex component 9
MEIS1 Meis homeobox 1
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NIPBL Nipped-B homolog (Drosophila)
NLK nemo-like kinase
NRIP1 nuclear receptor interacting protein 1
PDZRN3 PDZ domain containing ring finger 3
PHF21A PHD finger protein 21A
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRR15L proline rich 15-like
PTPRK protein tyrosine phosphatase, receptor type, K
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBM47 RNA binding motif protein 47
RCOR1 REST corepressor 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF121 ring finger protein 121
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
SFMBT1 Scm-like with four mbt domains 1
SHROOM2 shroom family member 2
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STARD13 StAR-related lipid transfer (START) domain containing 13
SYT1 synaptotagmin I
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TASP1 taspase, threonine aspartase, 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNS3 tensin 3
TPTE transmembrane phosphatase with tensin homology
TRAF5 TNF receptor-associated factor 5
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TTK TTK protein kinase
TULP4 tubby like protein 4
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
USP6NL USP6 N-terminal like
UVRAG UV radiation resistance associated
WDR26 WD repeat domain 26
WDR44 WD repeat domain 44
WDR7 WD repeat domain 7
WDR70 WD repeat domain 70
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZHX2 zinc fingers and homeoboxes 2
ZNF165 zinc finger protein 165