irinotecan-7498 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the irinotecan-7498 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
AEN apoptosis enhancing nuclease
ALDOC aldolase C, fructose-bisphosphate
AMH anti-Mullerian hormone
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARC activity-regulated cytoskeleton-associated protein
ASB1 ankyrin repeat and SOCS box containing 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C14ORF79 chromosome 14 open reading frame 79
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEL carboxyl ester lipase
CHKB choline kinase beta
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CSF1 colony stimulating factor 1 (macrophage)
CUZD1 CUB and zona pellucida-like domains 1
DDIT4 DNA-damage-inducible transcript 4
DIEXF digestive organ expansion factor homolog (zebrafish)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
EPHA2 EPH receptor A2
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FLCN folliculin
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPR87 G protein-coupled receptor 87
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HIC2 hypermethylated in cancer 2
HLA-E major histocompatibility complex, class I, E
HPX hemopexin
IER5 immediate early response 5
JAG1 jagged 1
JUN jun proto-oncogene
LIF leukemia inhibitory factor
LOC157562 uncharacterized LOC157562
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTB4R leukotriene B4 receptor
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSX1 msh homeobox 1
MXD4 MAX dimerization protein 4
NGDN neuroguidin, EIF4E binding protein
NHLH2 nescient helix loop helix 2
NUPR1 nuclear protein, transcriptional regulator, 1
NYNRIN NYN domain and retroviral integrase containing
OVGP1 oviductal glycoprotein 1, 120kDa
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PIDD1 p53-induced death domain protein 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDX2 peroxiredoxin 2
PRICKLE3 prickle homolog 3 (Drosophila)
RALGDS ral guanine nucleotide dissociation stimulator
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS2 regulator of G-protein signaling 2
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RIN1 Ras and Rab interactor 1
RNF19B ring finger protein 19B
RNF39 ring finger protein 39
RPS28 ribosomal protein S28
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFN stratifin
SIX2 SIX homeobox 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOCS1 suppressor of cytokine signaling 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TREX1 three prime repair exonuclease 1
TUBB2A tubulin, beta 2A class IIa
UCN urocortin
VAMP5 vesicle-associated membrane protein 5
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF34 zinc finger protein 34
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ADGRA3 adhesion G protein-coupled receptor A3
ADGRL2 adhesion G protein-coupled receptor L2
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGO2 argonaute RISC catalytic component 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP12 Rho GTPase activating protein 12
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX5 armadillo repeat containing, X-linked 5
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATAD2 ATPase family, AAA domain containing 2
BARD1 BRCA1 associated RING domain 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDK8 cyclin-dependent kinase 8
CENPE centromere protein E, 312kDa
CHD1 chromodomain helicase DNA binding protein 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
DAAM1 dishevelled associated activator of morphogenesis 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND1B DENN/MADD domain containing 1B
DMXL1 Dmx-like 1
DSCAM Down syndrome cell adhesion molecule
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EFNA4 ephrin-A4
EHBP1 EH domain binding protein 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHA4 EPH receptor A4
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2IP erbb2 interacting protein
ESRP1 epithelial splicing regulatory protein 1
FNBP1L formin binding protein 1-like
FNDC3B fibronectin type III domain containing 3B
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GHR growth hormone receptor
GIGYF2 GRB10 interacting GYF protein 2
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRHL2 grainyhead-like 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
HJURP Holliday junction recognition protein
HMG20A high mobility group 20A
JARID2 jumonji, AT rich interactive domain 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KNTC1 kinetochore associated 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MDN1 MDN1, midasin homolog (yeast)
MELK maternal embryonic leucine zipper kinase
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSH2 mutS homolog 2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK4 NIMA-related kinase 4
NEK7 NIMA-related kinase 7
NFE2L2 nuclear factor, erythroid 2-like 2
NIPBL Nipped-B homolog (Drosophila)
NMD3 NMD3 ribosome export adaptor
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
PHIP pleckstrin homology domain interacting protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRR15L proline rich 15-like
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRK protein tyrosine phosphatase, receptor type, K
RAI14 retinoic acid induced 14
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM47 RNA binding motif protein 47
RCOR1 REST corepressor 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SAP130 Sin3A-associated protein, 130kDa
SCAF8 SR-related CTD-associated factor 8
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC24B SEC24 family member B
SFMBT1 Scm-like with four mbt domains 1
SPC25 SPC25, NDC80 kinetochore complex component
STAG1 stromal antigen 1
TPX2 TPX2, microtubule-associated
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTK TTK protein kinase
UVRAG UV radiation resistance associated
VANGL1 VANGL planar cell polarity protein 1
WDR26 WD repeat domain 26
WDR70 WD repeat domain 70
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZHX2 zinc fingers and homeoboxes 2