ioxaglic acid-3528 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ioxaglic acid-3528 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ADAM22 ADAM metallopeptidase domain 22
ADGRG1 adhesion G protein-coupled receptor G1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMACR alpha-methylacyl-CoA racemase
APOC4 apolipoprotein C-IV
AQP4 aquaporin 4
BMP6 bone morphogenetic protein 6
C21ORF2 chromosome 21 open reading frame 2
CABP2 calcium binding protein 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CD58 CD58 molecule
CD82 CD82 molecule
CDC14A cell division cycle 14A
CDON cell adhesion associated, oncogene regulated
CEP112 centrosomal protein 112kDa
CFAP45 cilia and flagella associated protein 45
COL1A1 collagen, type I, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COPZ2 coatomer protein complex, subunit zeta 2
CST4 cystatin S
CTBP2 C-terminal binding protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXORF21 chromosome X open reading frame 21
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DENND6B DENN/MADD domain containing 6B
DNAH17 dynein, axonemal, heavy chain 17
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYSF dysferlin
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FGL1 fibrinogen-like 1
FOXF1 forkhead box F1
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GK glycerol kinase
GLP1R glucagon-like peptide 1 receptor
GLRX3 glutaredoxin 3
GM2A GM2 ganglioside activator
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR21 G protein-coupled receptor 21
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM7 glutamate receptor, metabotropic 7
GSPT1 G1 to S phase transition 1
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIPK3 homeodomain interacting protein kinase 3
HIST1H4A histone cluster 1, H4a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGHMBP2 immunoglobulin mu binding protein 2
INHBA inhibin, beta A
ITGA7 integrin, alpha 7
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
LOC729164 hCG1732469
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAPK7 mitogen-activated protein kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCR2 natural cytotoxicity triggering receptor 2
NDRG2 NDRG family member 2
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
OGFR opioid growth factor receptor
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR12D3 olfactory receptor, family 12, subfamily D, member 3
ORAI2 ORAI calcium release-activated calcium modulator 2
OSBPL3 oxysterol binding protein-like 3
PBX2 pre-B-cell leukemia homeobox 2
PCDH1 protocadherin 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSD3 pleckstrin and Sec7 domain containing 3
PTRF polymerase I and transcript release factor
PXN paxillin
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX15 SRY (sex determining region Y)-box 15
SSX1 synovial sarcoma, X breakpoint 1
STK11 serine/threonine kinase 11
SVIL supervillin
TBXA2R thromboxane A2 receptor
TFR2 transferrin receptor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WDR62 WD repeat domain 62
WNT2B wingless-type MMTV integration site family, member 2B
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF136 zinc finger protein 136
ZNF440 zinc finger protein 440
ZNF551 zinc finger protein 551
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACYP2 acylphosphatase 2, muscle type
ADAP2 ArfGAP with dual PH domains 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKRD10 ankyrin repeat domain 10
ANXA2P3 annexin A2 pseudogene 3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
BCL2L2 BCL2-like 2
C17ORF80 chromosome 17 open reading frame 80
CEP131 centrosomal protein 131kDa
CLDND1 claudin domain containing 1
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
CST6 cystatin E/M
CXCR2 chemokine (C-X-C motif) receptor 2
DCAF13 DDB1 and CUL4 associated factor 13
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOC2A double C2-like domains, alpha
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EPHA2 EPH receptor A2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155B family with sequence similarity 155, member B
FAM46C family with sequence similarity 46, member C
FLJ22184
FOXN2 forkhead box N2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GBP2 guanylate binding protein 2, interferon-inducible
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GRB14 growth factor receptor-bound protein 14
HIST1H1D histone cluster 1, H1d
HOXC8 homeobox C8
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCTD20 potassium channel tetramerization domain containing 20
KIAA0319L KIAA0319-like
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIG4 ligase IV, DNA, ATP-dependent
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LRP5L low density lipoprotein receptor-related protein 5-like
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEA6 melanoma antigen family A6
MANBA mannosidase, beta A, lysosomal
METTL16 methyltransferase like 16
MFSD11 major facilitator superfamily domain containing 11
MORC3 MORC family CW-type zinc finger 3
NES nestin
NKX3-2 NK3 homeobox 2
NOL12 nucleolar protein 12
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PACS1 phosphofurin acidic cluster sorting protein 1
PALM paralemmin
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PRODH proline dehydrogenase (oxidase) 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PYCRL pyrroline-5-carboxylate reductase-like
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF170 ring finger protein 170
RPL13P5 ribosomal protein L13 pseudogene 5
RUSC2 RUN and SH3 domain containing 2
SECTM1 secreted and transmembrane 1
SETD1B SET domain containing 1B
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX12 SRY (sex determining region Y)-box 12
SSBP3 single stranded DNA binding protein 3
TBCCD1 TBCC domain containing 1
TFB1M transcription factor B1, mitochondrial
THBS3 thrombospondin 3
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTBK2 tau tubulin kinase 2
TUBA3D tubulin, alpha 3d
TWF2 twinfilin actin binding protein 2
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBQLN4 ubiquilin 4
VASH2 vasohibin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF16 zinc finger protein 16
ZNF37BP zinc finger protein 37B, pseudogene
ZNF480 zinc finger protein 480
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF606 zinc finger protein 606
ZNF652 zinc finger protein 652