ion channel complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. (Gene Ontology, GO_0034702)
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Genes

342 proteins co-occuring with the ion channel complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 3.20996
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 2.8199
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.72789
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.09619
CATSPER1 cation channel, sperm associated 1 1.78649
CLCN3 chloride channel, voltage-sensitive 3 1.78452
CLCA1 chloride channel accessory 1 1.7747
CLCA2 chloride channel accessory 2 1.68116
CLCA4 chloride channel accessory 4 1.61941
CLCNKB chloride channel, voltage-sensitive Kb 1.54744
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 1.54291
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.50057
ANO1 anoctamin 1, calcium activated chloride channel 1.49436
INS insulin 1.38794
LGI1 leucine-rich, glioma inactivated 1 1.34774
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.28143
CLCN2 chloride channel, voltage-sensitive 2 1.27611
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 1.26551
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.23557
CATSPER2 cation channel, sperm associated 2 1.23557
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.20344
ADORA1 adenosine A1 receptor 1.1562
DNAH8 dynein, axonemal, heavy chain 8 1.14085
BEST1 bestrophin 1 1.13216
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.12552
CNTNAP2 contactin associated protein-like 2 1.05842
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.0403
CATSPER4 cation channel, sperm associated 4 1.01684
KNG1 kininogen 1 0.993672
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.988294
CATSPER3 cation channel, sperm associated 3 0.984393
GUCY2C guanylate cyclase 2C 0.974198
NPR1 natriuretic peptide receptor 1 0.957352
ANO2 anoctamin 2, calcium activated chloride channel 0.956395
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.944956
BEST4 bestrophin 4 0.931245
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.905531
BEST2 bestrophin 2 0.870426
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.862609
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.855717
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.845155
CLCN1 chloride channel, voltage-sensitive 1 0.836433
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.829089
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.829089
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.82863
UNC80 unc-80 homolog (C. elegans) 0.800645
CSN3 casein kappa 0.786444
CLCN5 chloride channel, voltage-sensitive 5 0.780497
CLEC19A C-type lectin domain family 19, member A 0.772732
ANO10 anoctamin 10 0.766349
EDN1 endothelin 1 0.749999
BEST3 bestrophin 3 0.749546
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.742769
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.697344
ANO9 anoctamin 9 0.693393
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.692516
CLCN6 chloride channel, voltage-sensitive 6 0.683771
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.678978
GLUD1 glutamate dehydrogenase 1 0.675499
ANO6 anoctamin 6 0.672026
GCK glucokinase (hexokinase 4) 0.645287
ADCY2 adenylate cyclase 2 (brain) 0.643144
AVP arginine vasopressin 0.642286
CTH cystathionine gamma-lyase 0.639289
KCNU1 potassium channel, subfamily U, member 1 0.63715
NRK Nik related kinase 0.636723
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.635868
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.628187
VIP vasoactive intestinal peptide 0.617557
NALCN sodium leak channel, non selective 0.615437
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.614165
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.607395
GCG glucagon 0.590973
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.589295
MGAM maltase-glucoamylase 0.575078
TTYH3 tweety family member 3 0.568832
CLCNKA chloride channel, voltage-sensitive Ka 0.564677
FXYD1 FXYD domain containing ion transport regulator 1 0.558871
PRKG1 protein kinase, cGMP-dependent, type I 0.5568
TAC1 tachykinin, precursor 1 0.555973
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.551012
ENSA endosulfine alpha 0.538649
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.536183
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.534951
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 0.528798
ANO5 anoctamin 5 0.521023
CATSPERB catsper channel auxiliary subunit beta 0.50635
CATSPERG catsper channel auxiliary subunit gamma 0.505944
PDE5A phosphodiesterase 5A, cGMP-specific 0.504318
SLC26A7 solute carrier family 26 (anion exchanger), member 7 0.499447
CALCA calcitonin-related polypeptide alpha 0.49418
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.492966
IL2RG interleukin 2 receptor, gamma 0.490135
CRYGD crystallin, gamma D 0.480453
HADH hydroxyacyl-CoA dehydrogenase 0.478038
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.472813
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.461998
ANO4 anoctamin 4 0.461599
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.458803
PRKG2 protein kinase, cGMP-dependent, type II 0.453621
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.453223
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.451233
PKD1L3 polycystic kidney disease 1-like 3 0.442896
GLI1 GLI family zinc finger 1 0.434985
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.431829
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.431041
PSCA prostate stem cell antigen 0.429072
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.423567
SP8 Sp8 transcription factor 0.417685
ANO7 anoctamin 7 0.414555
RPIA ribose 5-phosphate isomerase A 0.41143
PKD2L1 polycystic kidney disease 2-like 1 0.410259
LEP leptin 0.407529
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.400139
FOXF2 forkhead box F2 0.399363
DEGS2 delta(4)-desaturase, sphingolipid 2 0.398975
GLDN gliomedin 0.395485
NPPA natriuretic peptide A 0.392388
MBD5 methyl-CpG binding domain protein 5 0.390455
STC1 stanniocalcin 1 0.389682
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.38428
TALDO1 transaldolase 1 0.38428
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 0.383124
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.382354
STX1A syntaxin 1A (brain) 0.381199
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.380814
SGK1 serum/glucocorticoid regulated kinase 1 0.375818
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.374666
REN renin 0.371982
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.371599
NOS3 nitric oxide synthase 3 (endothelial cell) 0.370833
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.367771
KCNT1 potassium channel, sodium activated subfamily T, member 1 0.363567
SCN3A sodium channel, voltage gated, type III alpha subunit 0.360133
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.357467
GLRA3 glycine receptor, alpha 3 0.350622
SOD2 superoxide dismutase 2, mitochondrial 0.350243
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.349484
IL9 interleukin 9 0.348725
EDNRA endothelin receptor type A 0.348346
NTS neurotensin 0.347967
CHD4 chromodomain helicase DNA binding protein 4 0.345692
CBS cystathionine-beta-synthase 0.344935
ASIC1 acid sensing (proton gated) ion channel 1 0.344935
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.338128
CLCN7 chloride channel, voltage-sensitive 7 0.334733
TTYH1 tweety family member 1 0.334733
CLEC2B C-type lectin domain family 2, member B 0.323075
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.320826
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.315586
CLCN4 chloride channel, voltage-sensitive 4 0.30924
EDN3 endothelin 3 0.300682
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.299569
ANO3 anoctamin 3 0.299197
TBXA2R thromboxane A2 receptor 0.29623
ASIC2 acid sensing (proton gated) ion channel 2 0.292157
DPYSL5 dihydropyrimidinase-like 5 0.289199
BCHE butyrylcholinesterase 0.287721
CA2 carbonic anhydrase II 0.285876
PHF12 PHD finger protein 12 0.277774
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.277774
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.264946
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.264215
PLA2G1B phospholipase A2, group IB (pancreas) 0.26166
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 0.259109
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.258745
PDYN prodynorphin 0.257652
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.256561
EPHX2 epoxide hydrolase 2, cytoplasmic 0.255834
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.255834
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.253291
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.249302
ADRB2 adrenoceptor beta 2, surface 0.248578
ALPPL2 alkaline phosphatase, placental-like 2 0.248578
ALPL alkaline phosphatase, liver/bone/kidney 0.248216
NPY neuropeptide Y 0.247854
ALPP alkaline phosphatase, placental 0.247854
KCNK5 potassium channel, two pore domain subfamily K, member 5 0.24713
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.245685
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.244601
PNMA2 paraneoplastic Ma antigen 2 0.243519
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.242076
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.240276
SPATA21 spermatogenesis associated 21 0.238119
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.235607
ACOT7 acyl-CoA thioesterase 7 0.230601
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 0.225976
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.225267
TNF tumor necrosis factor 0.223497
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.22279
CCK cholecystokinin 0.222436
A4GALT alpha 1,4-galactosyltransferase 0.222083
CAT catalase 0.22173
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.221025
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.219969
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.213322
OPRM1 opioid receptor, mu 1 0.213322
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.21124
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.206423
VDAC1 voltage-dependent anion channel 1 0.202684
ACHE acetylcholinesterase (Yt blood group) 0.202684
SST somatostatin 0.198325
PKP2 plakophilin 2 0.196669
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.194371
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.193394
IL32 interleukin 32 0.186087
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.179167
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.178299
NPR2 natriuretic peptide receptor 2 0.176305
TBXAS1 thromboxane A synthase 1 (platelet) 0.175745
GAL galanin/GMAP prepropeptide 0.174911
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.170888
DRD2 dopamine receptor D2 0.170371
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.168598
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.164542
ANXA4 annexin A4 0.163641
SACS sacsin molecular chaperone 0.16342
LEPR leptin receptor 0.16233
JUN jun proto-oncogene 0.161484
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.160053
CNGA2 cyclic nucleotide gated channel alpha 2 0.159074
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.157943
PYY peptide YY 0.156688
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.142015
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.141883
GRIK1 glutamate receptor, ionotropic, kainate 1 0.138058
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.137966
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.137088
SOX5 SRY (sex determining region Y)-box 5 0.136916
CNTN2 contactin 2 (axonal) 0.136274
DPP6 dipeptidyl-peptidase 6 0.135834
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.13566
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.134868
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.134666
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 0.134086
CAMP cathelicidin antimicrobial peptide 0.13348
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.133291
SOX9 SRY (sex determining region Y)-box 9 0.132255
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.129586
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.129213
HVCN1 hydrogen voltage gated channel 1 0.12882
GRM1 glutamate receptor, metabotropic 1 0.127619
LRP4 low density lipoprotein receptor-related protein 4 0.127035
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.125945
GLRA1 glycine receptor, alpha 1 0.125148
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.12418
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.123988
FAM155B family with sequence similarity 155, member B 0.123094
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.122749
RELN reelin 0.122612
RHAG Rh-associated glycoprotein 0.121381
GRIP1 glutamate receptor interacting protein 1 0.119637
CA4 carbonic anhydrase IV 0.119277
GJA1 gap junction protein, alpha 1, 43kDa 0.118397
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.116271
FGF14 fibroblast growth factor 14 0.115287
MMP10 matrix metallopeptidase 10 0.114024
LAMA2 laminin, alpha 2 0.113545
AMPH amphiphysin 0.112735
GPR135 G protein-coupled receptor 135 0.112322
DERL1 derlin 1 0.112015
WARS tryptophanyl-tRNA synthetase 0.110988
DPYSL2 dihydropyrimidinase-like 2 0.110712
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.109789
HDAC5 histone deacetylase 5 0.109555
KMT2A lysine (K)-specific methyltransferase 2A 0.107639
FGF1 fibroblast growth factor 1 (acidic) 0.107313
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.107039
MEF2C myocyte enhancer factor 2C 0.105961
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.105897
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.104984
ENGASE endo-beta-N-acetylglucosaminidase 0.104659
AQP4 aquaporin 4 0.103946
PTAFR platelet-activating factor receptor 0.103166
SRY sex determining region Y 0.09632
CSN1S1 casein alpha s1 0.096033
LAMB2 laminin, beta 2 (laminin S) 0.085328
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.080024
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.079738
ADM2 adrenomedullin 2 0.079116
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.078697
GIP gastric inhibitory polypeptide 0.078173
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.078016
AKTIP AKT interacting protein 0.077911
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.077832
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.077461
PLSCR3 phospholipid scramblase 3 0.077064
QPCT glutaminyl-peptide cyclotransferase 0.077011
LAD1 ladinin 1 0.076533
FKBP1A FK506 binding protein 1A, 12kDa 0.076319
HCRT hypocretin (orexin) neuropeptide precursor 0.076026
FFAR1 free fatty acid receptor 1 0.075652
WNK1 WNK lysine deficient protein kinase 1 0.075599
LINS lines homolog (Drosophila) 0.07506
TXNDC9 thioredoxin domain containing 9 0.074818
KCNIP4 Kv channel interacting protein 4 0.074711
VEGFA vascular endothelial growth factor A 0.074549
PDZD3 PDZ domain containing 3 0.074388
HLA-C major histocompatibility complex, class I, C 0.074279
PSAT1 phosphoserine aminotransferase 1 0.074035
BAX BCL2-associated X protein 0.073763
CCL2 chemokine (C-C motif) ligand 2 0.073465
DNTT DNA nucleotidylexotransferase 0.07333
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.073275
CDO1 cysteine dioxygenase type 1 0.072729
HLA-DOB major histocompatibility complex, class II, DO beta 0.072702
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.072156
BACE1 beta-site APP-cleaving enzyme 1 0.072128
TRNAU1AP tRNA selenocysteine 1 associated protein 1 0.071661
PDE9A phosphodiesterase 9A 0.071606
ANK1 ankyrin 1, erythrocytic 0.071276
HNF4A hepatocyte nuclear factor 4, alpha 0.070892
NLRP12 NLR family, pyrin domain containing 12 0.070615
FOS FBJ murine osteosarcoma viral oncogene homolog 0.070588
GHRL ghrelin/obestatin prepropeptide 0.070505
TNNT2 troponin T type 2 (cardiac) 0.070256
PTGFR prostaglandin F receptor (FP) 0.0702
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.0702
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.07009
KLHL17 kelch-like family member 17 0.069896
FXYD3 FXYD domain containing ion transport regulator 3 0.069758
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.06973
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.069675
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.069564
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.069481
DMD dystrophin 0.069286
HDX highly divergent homeobox 0.069258
INSR insulin receptor 0.069147
GYG1 glycogenin 1 0.069091
NPPC natriuretic peptide C 0.069008
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.068841
C21ORF2 chromosome 21 open reading frame 2 0.068785
SIM2 single-minded family bHLH transcription factor 2 0.068618
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.068507
TJP1 tight junction protein 1 0.068396
IL13 interleukin 13 0.068285
OSTM1 osteopetrosis associated transmembrane protein 1 0.068229
GPER1 G protein-coupled estrogen receptor 1 0.068117
PTPRD protein tyrosine phosphatase, receptor type, D 0.067977
PLCG1 phospholipase C, gamma 1 0.067977
UBIAD1 UbiA prenyltransferase domain containing 1 0.067725
MMP7 matrix metallopeptidase 7 0.067725