intrinsic apoptotic signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). (Gene Ontology, GO_0097193)
External Link http://amigo.geneontology.org/amigo/term/GO:0097193
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Genes

168 genes participating in the intrinsic apoptotic signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AEN apoptosis enhancing nuclease
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
APOPT1 apoptogenic 1, mitochondrial
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BCL3 B-cell CLL/lymphoma 3
BID BH3 interacting domain death agonist
BMF Bcl2 modifying factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOK BCL2-related ovarian killer
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRSK2 BR serine/threonine kinase 2
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDIP1 cell death-inducing p53 target 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CIDEB cell death-inducing DFFA-like effector b
CRIP1 cysteine-rich protein 1 (intestinal)
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL5 cullin 5
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2IP DAB2 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DIABLO diablo, IAP-binding mitochondrial protein
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
EDA2R ectodysplasin A2 receptor
EI24 etoposide induced 2.4
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FHIT fragile histidine triad
FNIP2 folliculin interacting protein 2
GPX1 glutathione peroxidase 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIC1 hypermethylated in cancer 1
HINT1 histidine triad nucleotide binding protein 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTRA2 HtrA serine peptidase 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
JMY junction mediating and regulatory protein, p53 cofactor
LGALS12 lectin, galactoside-binding, soluble, 12
MAEL maelstrom spermatogenic transposon silencer
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MBD4 methyl-CpG binding domain protein 4
MCL1 myeloid cell leukemia 1
MELK maternal embryonic leucine zipper kinase
MLH1 mutL homolog 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
NBN nibrin
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NMT1 N-myristoyltransferase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD10 programmed cell death 10
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PERP PERP, TP53 apoptosis effector
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POLB polymerase (DNA directed), beta
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRODH proline dehydrogenase (oxidase) 1
PYCARD PYD and CARD domain containing
RNF7 ring finger protein 7
RPS27L ribosomal protein S27-like
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SART1 squamous cell carcinoma antigen recognized by T cells
SCN2A sodium channel, voltage gated, type II alpha subunit
SELK selenoprotein K
SFN stratifin
SGPP1 sphingosine-1-phosphate phosphatase 1
SHISA5 shisa family member 5
SIRT1 sirtuin 1
SNW1 SNW domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
ST20 suppressor of tumorigenicity 20
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
STK25 serine/threonine kinase 25
TFDP1 transcription factor Dp-1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM109 transmembrane protein 109
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TRIB3 tribbles pseudokinase 3
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBE2K ubiquitin-conjugating enzyme E2K
USP28 ubiquitin specific peptidase 28
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF385B zinc finger protein 385B
ZNF622 zinc finger protein 622