intrinsic apoptotic signaling pathway in response to dna damage Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. (Gene Ontology, GO_0008630)
External Link http://amigo.geneontology.org/amigo/term/GO:0008630
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Genes

76 genes participating in the intrinsic apoptotic signaling pathway in response to dna damage biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AEN apoptosis enhancing nuclease
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BCL3 B-cell CLL/lymphoma 3
BOK BCL2-related ovarian killer
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDIP1 cell death-inducing p53 target 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK2 checkpoint kinase 2
CIDEB cell death-inducing DFFA-like effector b
CRIP1 cysteine-rich protein 1 (intestinal)
DDIT4 DNA-damage-inducible transcript 4
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
EI24 etoposide induced 2.4
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
ERCC6 excision repair cross-complementation group 6
FNIP2 folliculin interacting protein 2
HIC1 hypermethylated in cancer 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HTRA2 HtrA serine peptidase 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
MAEL maelstrom spermatogenic transposon silencer
MBD4 methyl-CpG binding domain protein 4
MCL1 myeloid cell leukemia 1
MLH1 mutL homolog 1
MOAP1 modulator of apoptosis 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUPR1 nuclear protein, transcriptional regulator, 1
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POLB polymerase (DNA directed), beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PYCARD PYD and CARD domain containing
RPS27L ribosomal protein S27-like
SFN stratifin
SHISA5 shisa family member 5
SIRT1 sirtuin 1
SNW1 SNW domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
ST20 suppressor of tumorigenicity 20
TMEM109 transmembrane protein 109
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
USP28 ubiquitin specific peptidase 28
XPA xeroderma pigmentosum, complementation group A