interleukin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An interleukin is a multifunctional cytokine produced by leukocytes for regulating immune responses. (Experimental Factor Ontology, EFO_0004100)
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Genes

271 genes co-occuring with the biological term interleukin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADAM33 ADAM metallopeptidase domain 33
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
ADRA1A adrenoceptor alpha 1A
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT2 angiopoietin 2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
B2M beta-2-microglobulin
B3GAT1 beta-1,3-glucuronyltransferase 1
BCL2 B-cell CLL/lymphoma 2
BPI bactericidal/permeability-increasing protein
BTLA B and T lymphocyte associated
CADM1 cell adhesion molecule 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCR3 chemokine (C-C motif) receptor 3
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CREM cAMP responsive element modulator
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A cytochrome P450, family 3, subfamily A
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFT1P2 defensin, theta 1 pseudogene 2
DOCK10 dedicator of cytokinesis 10
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ERAP1 endoplasmic reticulum aminopeptidase 1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FERMT2 fermitin family member 2
FFAR2 free fatty acid receptor 2
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FOSL2 FOS-like antigen 2
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GSK3B glycogen synthase kinase 3 beta
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAS2 hyaluronan synthase 2
HAVCR2 hepatitis A virus cellular receptor 2
HDAC11 histone deacetylase 11
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXC9 homeobox C9
HP haptoglobin
HSF1 heat shock transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNL1 interferon, lambda 1
IFNL2 interferon, lambda 2
IFNL3 interferon, lambda 3
IFNLR1 interferon, lambda receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL21 interleukin 21
IL21R interleukin 21 receptor
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL24 interleukin 24
IL25 interleukin 25
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL33 interleukin 33
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9 interleukin 9
ILF3 interleukin enhancer binding factor 3, 90kDa
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
JAK1 Janus kinase 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIAA1109 KIAA1109
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LEP leptin
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR155 microRNA 155
MIR181A1 microRNA 181a-1
MIR193A microRNA 193a
MIR193B microRNA 193b
MIR223 microRNA 223
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MSR1 macrophage scavenger receptor 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NKRF NFKB repressing factor
NLRC5 NLR family, CARD domain containing 5
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR2E1 nuclear receptor subfamily 2, group E, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
PRDM1 PR domain containing 1, with ZNF domain
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCZ protein kinase C, zeta
PSEN1 presenilin 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDR2 prostaglandin D2 receptor 2
PTGFR prostaglandin F receptor (FP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYCARD PYD and CARD domain containing
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100B S100 calcium binding protein B
SDC2 syndecan 2
SDC4 syndecan 4
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SLPI secretory leukocyte peptidase inhibitor
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
ST18 suppression of tumorigenicity 18, zinc finger
ST2 suppression of tumorigenicity 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO3 small ubiquitin-like modifier 3
SYK spleen tyrosine kinase
TAC1 tachykinin, precursor 1
TBX21 T-box 21
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP63 tumor protein p63
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSLP thymic stromal lymphopoietin
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WNT4 wingless-type MMTV integration site family, member 4
XPO5 exportin 5
ZNF366 zinc finger protein 366