interleukin-35 complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space. (Gene Ontology, GO_0070745)
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Genes

303 proteins co-occuring with the interleukin-35 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDK5 cyclin-dependent kinase 5 3.79959
EBI3 Epstein-Barr virus induced 3 2.15371
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 1.97132
IL12RB2 interleukin 12 receptor, beta 2 1.61295
IL23A interleukin 23, alpha subunit p19 1.48192
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 1.47627
IL12RB1 interleukin 12 receptor, beta 1 1.44629
IL27 interleukin 27 1.41699
TAGAP T-cell activation RhoGTPase activating protein 1.26551
IL12A interleukin 12A 1.24393
IL12B interleukin 12B 1.22724
IL10RB interleukin 10 receptor, beta 1.20447
FOXP3 forkhead box P3 1.17517
MOG myelin oligodendrocyte glycoprotein 1.16747
RGS1 regulator of G-protein signaling 1 1.10205
STAT4 signal transducer and activator of transcription 4 1.06448
CCNI cyclin I 1.0569
SH2B3 SH2B adaptor protein 3 1.0423
RELN reelin 1.03829
IFNG interferon, gamma 1.03428
CARD17 caspase recruitment domain family, member 17 1.02929
CD4 CD4 molecule 1.02032
IL18RAP interleukin 18 receptor accessory protein 1.0104
IL1B interleukin 1, beta 0.994652
IL27RA interleukin 27 receptor, alpha 0.954961
ANXA1 annexin A1 0.945432
TNF tumor necrosis factor 0.934072
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.908785
IL2RB interleukin 2 receptor, beta 0.901818
GSK3B glycogen synthase kinase 3 beta 0.899499
CDK4 cyclin-dependent kinase 4 0.894406
CDK2 cyclin-dependent kinase 2 0.892093
TBX21 T-box 21 0.891169
LPP LIM domain containing preferred translocation partner in lipoma 0.884705
FAM167A family with sequence similarity 167, member A 0.86077
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.844237
CDK16 cyclin-dependent kinase 16 0.808441
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.807982
OR8D4 olfactory receptor, family 8, subfamily D, member 4 0.807982
IL1A interleukin 1, alpha 0.803855
UPK3B uroplakin 3B 0.795145
ZSCAN31 zinc finger and SCAN domain containing 31 0.786444
THSD4 thrombospondin, type I, domain containing 4 0.786444
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.785529
CDK18 cyclin-dependent kinase 18 0.782326
CD40 CD40 molecule, TNF receptor superfamily member 5 0.766804
IL10RA interleukin 10 receptor, alpha 0.762252
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.748641
IRF1 interferon regulatory factor 1 0.747285
DENND1B DENN/MADD domain containing 1B 0.737363
IRF5 interferon regulatory factor 5 0.736464
CAST calpastatin 0.726152
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.724365
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.717236
CXCL10 chemokine (C-X-C motif) ligand 10 0.713238
AATK apoptosis-associated tyrosine kinase 0.708808
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.705273
MPHOSPH9 M-phase phosphoprotein 9 0.704831
CABLES1 Cdk5 and Abl enzyme substrate 1 0.70439
MAPT microtubule-associated protein tau 0.696905
PTER phosphotriesterase related 0.695587
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.692078
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.691202
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.689013
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.677673
POU2AF1 POU class 2 associating factor 1 0.67246
GJB5 gap junction protein, beta 5, 31.1kDa 0.671593
MAPK1 mitogen-activated protein kinase 1 0.668126
CCL1 chemokine (C-C motif) ligand 1 0.65388
CCNH cyclin H 0.648721
CENPV centromere protein V 0.631171
TMEM39A transmembrane protein 39A 0.631171
TTBK1 tau tubulin kinase 1 0.629892
ZPBP2 zona pellucida binding protein 2 0.620954
FADD Fas (TNFRSF6)-associated via death domain 0.616709
CCL5 chemokine (C-C motif) ligand 5 0.609509
TSSK6 testis-specific serine kinase 6 0.609086
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.607395
CD40LG CD40 ligand 0.601909
GJB3 gap junction protein, beta 3, 31kDa 0.601487
BCL2L1 BCL2-like 1 0.594753
GATA3 GATA binding protein 3 0.584268
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.579669
ADGRG4 adhesion G protein-coupled receptor G4 0.578833
BLK BLK proto-oncogene, Src family tyrosine kinase 0.578416
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.571745
CXCL9 chemokine (C-X-C motif) ligand 9 0.567585
IL18 interleukin 18 0.565923
FAM13A family with sequence similarity 13, member A 0.564677
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.560528
BIRC3 baculoviral IAP repeat containing 3 0.548947
TLR4 toll-like receptor 4 0.546472
RYBP RING1 and YY1 binding protein 0.542764
STXBP6 syntaxin binding protein 6 (amisyn) 0.54194
CDK1 cyclin-dependent kinase 1 0.540294
TNPO3 transportin 3 0.540294
TPT1 tumor protein, translationally-controlled 1 0.537827
TLR7 toll-like receptor 7 0.537827
NELFCD negative elongation factor complex member C/D 0.534951
TEN1 TEN1 CST complex subunit 0.533719
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.533719
TGFB1 transforming growth factor, beta 1 0.519389
TFG TRK-fused gene 0.517756
IL1RN interleukin 1 receptor antagonist 0.51694
CXCL11 chemokine (C-X-C motif) ligand 11 0.507163
PXK PX domain containing serine/threonine kinase 0.504318
LMTK2 lemur tyrosine kinase 2 0.503506
EGR1 early growth response 1 0.492561
CCL22 chemokine (C-C motif) ligand 22 0.489731
GJB4 gap junction protein, beta 4, 30.3kDa 0.487307
GSTCD glutathione S-transferase, C-terminal domain containing 0.487307
IL10 interleukin 10 0.483676
PSD3 pleckstrin and Sec7 domain containing 3 0.482467
PHF1 PHD finger protein 1 0.481661
OR51E1 olfactory receptor, family 51, subfamily E, member 1 0.479647
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.475625
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.475223
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.475223
TLR3 toll-like receptor 3 0.473215
CCR3 chemokine (C-C motif) receptor 3 0.466799
TP53 tumor protein p53 0.464397
TMEM163 transmembrane protein 163 0.461199
RORC RAR-related orphan receptor C 0.456012
TLR2 toll-like receptor 2 0.454418
DEDD death effector domain containing 0.451631
HRAS Harvey rat sarcoma viral oncogene homolog 0.451233
CDK17 cyclin-dependent kinase 17 0.448848
TSLP thymic stromal lymphopoietin 0.448054
LTA lymphotoxin alpha 0.447656
DCX doublecortin 0.445672
BACE1 beta-site APP-cleaving enzyme 1 0.443292
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.435775
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.431435
CCL3 chemokine (C-C motif) ligand 3 0.429859
CXCR3 chemokine (C-X-C motif) receptor 3 0.428678
CCL24 chemokine (C-C motif) ligand 24 0.424353
IL22RA2 interleukin 22 receptor, alpha 2 0.420036
CD80 CD80 molecule 0.414946
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.414946
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 0.412601
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.409089
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.403248
CCL4 chemokine (C-C motif) ligand 4 0.402081
MYD88 myeloid differentiation primary response 88 0.399363
OLIG3 oligodendrocyte transcription factor 3 0.398199
CCL19 chemokine (C-C motif) ligand 19 0.39626
GPRIN1 G protein regulated inducer of neurite outgrowth 1 0.395873
PKN1 protein kinase N1 0.395485
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 0.389682
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 0.385436
APAF1 apoptotic peptidase activating factor 1 0.385051
ANXA4 annexin A4 0.382739
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.381969
GCHFR GTP cyclohydrolase I feedback regulator 0.381584
ADAMTSL1 ADAMTS-like 1 0.378891
STAT1 signal transducer and activator of transcription 1, 91kDa 0.374666
CD86 CD86 molecule 0.372366
CD83 CD83 molecule 0.371599
MYEF2 myelin expression factor 2 0.369684
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.367388
MIEN1 migration and invasion enhancer 1 0.367388
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.363949
MNDA myeloid cell nuclear differentiation antigen 0.363567
CXCR5 chemokine (C-X-C motif) receptor 5 0.359752
NEFH neurofilament, heavy polypeptide 0.358228
CDK6 cyclin-dependent kinase 6 0.357086
IL4 interleukin 4 0.354042
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.353662
PLD4 phospholipase D family, member 4 0.350622
KIAA1109 KIAA1109 0.346829
GSDMB gasdermin B 0.345692
CXCL3 chemokine (C-X-C motif) ligand 3 0.345314
CDK7 cyclin-dependent kinase 7 0.335864
IL2RG interleukin 2 receptor, gamma 0.334356
CCR6 chemokine (C-C motif) receptor 6 0.332472
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.331719
RCAN3 RCAN family member 3 0.331342
C1QBP complement component 1, q subcomponent binding protein 0.330966
SP9 Sp9 transcription factor 0.329837
CADM2 cell adhesion molecule 2 0.3227
LTB lymphotoxin beta (TNF superfamily, member 3) 0.3227
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.322325
CCR7 chemokine (C-C motif) receptor 7 0.31783
CCL15 chemokine (C-C motif) ligand 15 0.316708
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.316708
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.314465
SP4 Sp4 transcription factor 0.312971
NGF nerve growth factor (beta polypeptide) 0.311478
BAX BCL2-associated X protein 0.310732
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.309613
RSAD2 radical S-adenosyl methionine domain containing 2 0.30924
CXCL6 chemokine (C-X-C motif) ligand 6 0.307377
MT1M metallothionein 1M 0.305888
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.302912
OASL 2'-5'-oligoadenylate synthetase-like 0.30254
FGF3 fibroblast growth factor 3 0.301797
TLR9 toll-like receptor 9 0.300311
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.300311
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.300311
TNIP1 TNFAIP3 interacting protein 1 0.298084
STK4 serine/threonine kinase 4 0.296601
CCND1 cyclin D1 0.29586
IRF7 interferon regulatory factor 7 0.295489
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.295119
CSN1S1 casein alpha s1 0.294007
IFNGR1 interferon gamma receptor 1 0.293637
NEK4 NIMA-related kinase 4 0.292527
IFNB1 interferon, beta 1, fibroblast 0.285507
IL2RA interleukin 2 receptor, alpha 0.284032
MRPL41 mitochondrial ribosomal protein L41 0.280716
KCNK12 potassium channel, two pore domain subfamily K, member 12 0.277038
CXCR2 chemokine (C-X-C motif) receptor 2 0.275202
CARD9 caspase recruitment domain family, member 9 0.268603
IRF8 interferon regulatory factor 8 0.267871
POU3F3 POU class 3 homeobox 3 0.267139
HTRA2 HtrA serine peptidase 2 0.266774
IL17A interleukin 17A 0.262755
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.262755
CRMP1 collapsin response mediator protein 1 0.26239
ANXA2 annexin A2 0.26166
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.26166
CLEC16A C-type lectin domain family 16, member A 0.258016
CCL2 chemokine (C-C motif) ligand 2 0.25438
ALOX12 arachidonate 12-lipoxygenase 0.252927
CDC27 cell division cycle 27 0.252927
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.250751
CCNB3 cyclin B3 0.249664
GUCA2B guanylate cyclase activator 2B (uroguanylin) 0.249664
COL25A1 collagen, type XXV, alpha 1 0.248578
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.244962
CCNG1 cyclin G1 0.244962
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.244601
CCR1 chemokine (C-C motif) receptor 1 0.243519
ASTN1 astrotactin 1 0.241356
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.236324
CD5L CD5 molecule-like 0.235249
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.233101
TCHH trichohyalin 0.231672
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.225267
INS insulin 0.224204
CPLX3 complexin 3 0.22385
STX1A syntaxin 1A (brain) 0.223143
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.22279
BDNF brain-derived neurotrophic factor 0.22279
CARD16 caspase recruitment domain family, member 16 0.22173
LEF1 lymphoid enhancer-binding factor 1 0.22173
ALOX15B arachidonate 15-lipoxygenase, type B 0.221025
MAP1B microtubule-associated protein 1B 0.221025
PARP1 poly (ADP-ribose) polymerase 1 0.219969
MIR107 microRNA 107 0.219969
IL7R interleukin 7 receptor 0.218563
HSF2 heat shock transcription factor 2 0.218212
APP amyloid beta (A4) precursor protein 0.215761
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.215063
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.215063
DNTT DNA nucleotidylexotransferase 0.214366
IGHE immunoglobulin heavy constant epsilon 0.212627
GOLM1 golgi membrane protein 1 0.21228
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.210549
ANXA13 annexin A13 0.210549
DAD1 defender against cell death 1 0.210549
NEFM neurofilament, medium polypeptide 0.208825
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.207451
CCL7 chemokine (C-C motif) ligand 7 0.207451
CTNND2 catenin (cadherin-associated protein), delta 2 0.206766
KIAA0319 KIAA0319 0.203361
NINJ1 ninjurin 1 0.202684
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.200328
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.199993
IFNLR1 interferon, lambda receptor 1 0.199659
CCL16 chemokine (C-C motif) ligand 16 0.197993
MIOX myo-inositol oxygenase 0.197662
PLXNB3 plexin B3 0.197662
CNST consortin, connexin sorting protein 0.195353
NES nestin 0.194045
IFNA1 interferon, alpha 1 0.191135
FAXDC2 fatty acid hydroxylase domain containing 2 0.190175
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.189222
OR5AC2 olfactory receptor, family 5, subfamily AC, member 2 0.180634
FOS FBJ murine osteosarcoma viral oncogene homolog 0.179459
PROK2 prokineticin 2 0.178299
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.17687
CDKN2A cyclin-dependent kinase inhibitor 2A 0.176305
IL18R1 interleukin 18 receptor 1 0.175466
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.174911
ITSN2 intersectin 2 0.171937
ANXA6 annexin A6 0.171149
FGF19 fibroblast growth factor 19 0.170114
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.169604
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.169604
CXCL16 chemokine (C-X-C motif) ligand 16 0.169604
HHIP hedgehog interacting protein 0.168349
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.167611
CXCL13 chemokine (C-X-C motif) ligand 13 0.167125
GJA4 gap junction protein, alpha 4, 37kDa 0.166405
FGFBP1 fibroblast growth factor binding protein 1 0.166167
LGALS4 lectin, galactoside-binding, soluble, 4 0.165697
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.161068
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.160863
FHIT fragile histidine triad 0.158882
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.158882
FGF13 fibroblast growth factor 13 0.158692
CXCL5 chemokine (C-X-C motif) ligand 5 0.156863