integumentary system disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages. (Human Disease Ontology, DOID_16)
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Genes

144 genes associated with the disease integumentary system disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AR androgen receptor 2.57534
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.90585
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 1.68372
MICB MHC class I polypeptide-related sequence B 1.61356
OR10A3 olfactory receptor, family 10, subfamily A, member 3 1.46288
GLB1 galactosidase, beta 1 1.41058
BLK BLK proto-oncogene, Src family tyrosine kinase 1.40325
IL12B interleukin 12B 1.39702
ANXA6 annexin A6 1.39702
RAET1L retinoic acid early transcript 1L 1.37597
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 1.35143
ZNF365 zinc finger protein 365 1.34736
CCDC80 coiled-coil domain containing 80 1.32252
NOTCH4 notch 4 1.30085
ULBP3 UL16 binding protein 3 1.25088
IL18R1 interleukin 18 receptor 1 1.24793
HLA-C major histocompatibility complex, class I, C 1.24299
TRAF3IP2 TRAF3 interacting protein 2 1.17894
PAX1 paired box 1 1.02486
OVOL1 ovo-like zinc finger 1 0.965481
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.965481
PRR23A proline rich 23A 0.945428
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.945428
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.910378
IL2RA interleukin 2 receptor, alpha 0.894262
HDAC9 histone deacetylase 9 0.894262
ITPKC inositol-trisphosphate 3-kinase C 0.872896
FLG filaggrin 0.835734
VWA7 von Willebrand factor A domain containing 7 0.817078
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.790827
ERAP1 endoplasmic reticulum aminopeptidase 1 0.774217
CAST calpastatin 0.774217
ICOS inducible T-cell co-stimulator 0.774217
TYK2 tyrosine kinase 2 0.7623
NOS2 nitric oxide synthase 2, inducible 0.7623
HLA-DOB major histocompatibility complex, class II, DO beta 0.752991
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.738873
STK19 serine/threonine kinase 19 0.738873
TARDBP TAR DNA binding protein 0.728541
LCE3C late cornified envelope 3C 0.682635
MIA melanoma inhibitory activity 0.670996
CFB complement factor B 0.670996
SPPL2C signal peptide peptidase like 2C 0.661797
TNXB tenascin XB 0.647573
ATF6B activating transcription factor 6 beta 0.647573
C11ORF30 chromosome 11 open reading frame 30 0.641775
FBXL19 F-box and leucine-rich repeat protein 19 0.63666
HLA-B major histocompatibility complex, class I, B 0.63207
STAT2 signal transducer and activator of transcription 2, 113kDa 0.63207
MICA MHC class I polypeptide-related sequence A 0.602429
SETBP1 SET binding protein 1 0.58494
IL21 interleukin 21 0.544585
ACTL9 actin-like 9 0.544585
PUS10 pseudouridylate synthase 10 0.52461
SPATA2 spermatogenesis associated 2 0.52461
ERBB3 erb-b2 receptor tyrosine kinase 3 0.52461
LCE3A late cornified envelope 3A 0.52461
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.486425
SUOX sulfite oxidase 0.486425
POU5F1 POU class 5 homeobox 1 0.486425
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.486425
IKZF4 IKAROS family zinc finger 4 (Eos) 0.486425
KIAA0391 KIAA0391 0.486425
KIAA1109 KIAA1109 0.486425
IL23R interleukin 23 receptor 0.464771
CENPU centromere protein U 0.464771
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.464771
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.449873
KIF3A kinesin family member 3A 0.449873
RAB5B RAB5B, member RAS oncogene family 0.438544
CD40 CD40 molecule, TNF receptor superfamily member 5 0.438544
BAG6 BCL2-associated athanogene 6 0.429338
IFNLR1 interferon, lambda receptor 1 0.4215
CCDC88B coiled-coil domain containing 88B 0.414708
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.414708
HLA-A major histocompatibility complex, class I, A 0.403461
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.403461
FAM27L family with sequence similarity 27-like 0.403461
CDK2 cyclin-dependent kinase 2 0.368757
BAD BCL2-associated agonist of cell death 0.368757
IL2 interleukin 2 0.368757
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.368757
STX17 syntaxin 17 0.368757
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.368757
IER3 immediate early response 3 0.345945
MUC21 mucin 21, cell surface associated 0.345945
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.345945
TECRL trans-2,3-enoyl-CoA reductase-like 0.345945
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.345945
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.345945
SLC44A4 solute carrier family 44, member 4 0.327313
PRDX5 peroxiredoxin 5 0.327313
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.327313
C6ORF25 chromosome 6 open reading frame 25 0.327313
HYAL1 hyaluronoglucosaminidase 1 0.311576
APOM apolipoprotein M 0.311576
MED30 mediator complex subunit 30 0.311576
DPCR1 diffuse panbronchiolitis critical region 1 0.311576
RNASEH2C ribonuclease H2, subunit C 0.297866
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.285417
FHIT fragile histidine triad 0.285417
RPS26 ribosomal protein S26 0.256228
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.256228
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.256228
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.256228
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.256228
IL13 interleukin 13 0.197766
NKX2-6 NK2 homeobox 6 0.197766
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.197766
COG6 component of oligomeric golgi complex 6 0.197766
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.197766
C6ORF15 chromosome 6 open reading frame 15 0.197766
RNF114 ring finger protein 114 0.197766
ZFHX3 zinc finger homeobox 3 0.197766
DYTN dystrotelin 0.197766
PELI1 pellino E3 ubiquitin protein ligase 1 0.197766
STK32A serine/threonine kinase 32A 0.197766
DACH1 dachshund family transcription factor 1 0.197766
OAF OAF homolog (Drosophila) 0.15771
ADIPOR2 adiponectin receptor 2 0.15771
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.15771
HSPA1L heat shock 70kDa protein 1-like 0.15771
LRRC32 leucine rich repeat containing 32 0.15771
PRRC2A proline-rich coiled-coil 2A 0.126165
IRF2BPL interferon regulatory factor 2 binding protein-like 0.100789
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.100789
RASAL2 RAS protein activator like 2 0.100789
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 0.100789
NELL1 NEL-like 1 (chicken) 0.100789
PSKH2 protein serine kinase H2 0.100789
ZNF521 zinc finger protein 521 0.080593
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.080593
RGS6 regulator of G-protein signaling 6 0.080593
CLEC16A C-type lectin domain family 16, member A 0.080593
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.080593
NCF4 neutrophil cytosolic factor 4, 40kDa 0.080593
TSC1 tuberous sclerosis 1 0.080593
ZNF407 zinc finger protein 407 0.064973
IGHV2-70 immunoglobulin heavy variable 2-70 0.064973
BTBD1 BTB (POZ) domain containing 1 0.064973
BCL7C B-cell CLL/lymphoma 7C 0.052255
MRPS22 mitochondrial ribosomal protein S22 0.052255
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.043246
CAMTA1 calmodulin binding transcription activator 1 0.043246