insulin-like growth factor binding protein complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. (Gene Ontology, GO_0016942)
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117 proteins co-occuring with the insulin-like growth factor binding protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 5.05307
IGF1 insulin-like growth factor 1 (somatomedin C) 4.76074
IGFBP1 insulin-like growth factor binding protein 1 4.3108
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 4.20323
IGFBP5 insulin-like growth factor binding protein 5 3.53581
IGFBP6 insulin-like growth factor binding protein 6 2.80681
IGF2 insulin-like growth factor 2 2.24819
INS insulin 2.14788
IGFBP7 insulin-like growth factor binding protein 7 2.03724
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.98479
IGFBP4 insulin-like growth factor binding protein 4 1.96286
GHR growth hormone receptor 1.83135
IGF1R insulin-like growth factor 1 receptor 1.7984
PAPPA2 pappalysin 2 1.52259
GH1 growth hormone 1 1.2777
IGFALS insulin-like growth factor binding protein, acid labile subunit 1.26762
INSR insulin receptor 1.15057
LEP leptin 1.11684
SHBG sex hormone-binding globulin 1.06802
IGF2R insulin-like growth factor 2 receptor 1.06094
GHRH growth hormone releasing hormone 1.03029
TGFB1 transforming growth factor, beta 1 0.937377
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.928892
HTRA1 HtrA serine peptidase 1 0.845614
CYR61 cysteine-rich, angiogenic inducer, 61 0.836433
IRS1 insulin receptor substrate 1 0.835056
IGFBPL1 insulin-like growth factor binding protein-like 1 0.832761
BGLAP bone gamma-carboxyglutamate (gla) protein 0.817158
KLK3 kallikrein-related peptidase 3 0.796062
CTGF connective tissue growth factor 0.750452
SST somatostatin 0.736464
PTH parathyroid hormone 0.710579
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.708808
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.700863
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.689888
GHRL ghrelin/obestatin prepropeptide 0.669858
WISP3 WNT1 inducible signaling pathway protein 3 0.668126
FGF2 fibroblast growth factor 2 (basic) 0.66164
NOV nephroblastoma overexpressed 0.656033
ADAM12 ADAM metallopeptidase domain 12 0.644429
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.635013
GCG glucagon 0.611201
PAEP progestagen-associated endometrial protein 0.606128
SEBOX SEBOX homeobox 0.598117
MSTN myostatin 0.583431
LRP5 low density lipoprotein receptor-related protein 5 0.579669
FGF7 fibroblast growth factor 7 0.563847
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.550599
M6PR mannose-6-phosphate receptor (cation dependent) 0.541529
ESR1 estrogen receptor 1 0.537416
SIGLEC6 sialic acid binding Ig-like lectin 6 0.523476
WISP1 WNT1 inducible signaling pathway protein 1 0.519389
IL1B interleukin 1, beta 0.517756
LRRC70 leucine rich repeat containing 70 0.49418
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.492561
IL6 interleukin 6 0.485289
PRL prolactin 0.482064
MYOG myogenin (myogenic factor 4) 0.465598
IER5L immediate early response 5-like 0.427497
ALB albumin 0.423567
WISP2 WNT1 inducible signaling pathway protein 2 0.419252
ALPPL2 alkaline phosphatase, placental-like 2 0.411039
ALPL alkaline phosphatase, liver/bone/kidney 0.410649
ALPP alkaline phosphatase, placental 0.410259
IFI30 interferon, gamma-inducible protein 30 0.408699
RNASEH2A ribonuclease H2, subunit A 0.404415
ANGPTL5 angiopoietin-like 5 0.398199
TNF tumor necrosis factor 0.385051
POMC proopiomelanocortin 0.380814
FGF1 fibroblast growth factor 1 (acidic) 0.380814
IRS2 insulin receptor substrate 2 0.378122
ZNF84 zinc finger protein 84 0.367771
TGFB2 transforming growth factor, beta 2 0.358228
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.351382
CSH2 chorionic somatomammotropin hormone 2 0.333225
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.319328
CRP C-reactive protein, pentraxin-related 0.319328
FSHR follicle stimulating hormone receptor 0.310732
TF transferrin 0.307377
TTR transthyretin 0.30626
FN1 fibronectin 1 0.304399
CSN1S1 casein alpha s1 0.291417
OBSL1 obscurin-like 1 0.286245
FST follistatin 0.284769
TRIP12 thyroid hormone receptor interactor 12 0.2719
KLHL21 kelch-like family member 21 0.264581
CCDC8 coiled-coil domain containing 8 0.264581
ORM1 orosomucoid 1 0.263485
ANGPT4 angiopoietin 4 0.254017
PLG plasminogen 0.251476
TP53 tumor protein p53 0.250389
BHMT betaine--homocysteine S-methyltransferase 0.242076
PGF placental growth factor 0.239197
BMP7 bone morphogenetic protein 7 0.239197
PGR progesterone receptor 0.23776
TIMP1 TIMP metallopeptidase inhibitor 1 0.237401
NPY4R neuropeptide Y receptor Y4 0.235249
GDF11 growth differentiation factor 11 0.227397
STAT5B signal transducer and activator of transcription 5B 0.217861
PDGFB platelet-derived growth factor beta polypeptide 0.210894
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.203361
CHRD chordin 0.202346
WT1 Wilms tumor 1 0.198658
COL1A2 collagen, type I, alpha 2 0.196999
OSBPL5 oxysterol binding protein-like 5 0.195025
IL15RA interleukin 15 receptor, alpha 0.193719
CUL7 cullin 7 0.182422
FBXO32 F-box protein 32 0.180634
MIIP migration and invasion inhibitory protein 0.177724
TG thyroglobulin 0.173003
KLK1 kallikrein 1 0.170888
PTEN phosphatase and tensin homolog 0.167856
YIPF1 Yip1 domain family, member 1 0.167366
IL1A interleukin 1, alpha 0.162546
EGFR epidermal growth factor receptor 0.160658
GBP5 guanylate binding protein 5 0.159856
CORIN corin, serine peptidase 0.158502