insulin signaling pathway Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description Insulin, the peptide hormone, secreted by the pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes. (Pathway Ontology, PW_0000143)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04910.html
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131 proteins participating in the insulin signaling pathway pathway from the KEGG Pathways dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARAF A-Raf proto-oncogene, serine/threonine kinase
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML6 calmodulin-like 6
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
EXOC7 exocyst complex component 7
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FBP2 fructose-1,6-bisphosphatase 2
FLOT1 flotillin 1
FLOT2 flotillin 2
FOXO1 forkhead box O1
G6PC glucose-6-phosphatase, catalytic subunit
G6PC2 glucose-6-phosphatase, catalytic, 2
GCK glucokinase (hexokinase 4)
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
GYS2 glycogen synthase 2 (liver)
HRAS Harvey rat sarcoma viral oncogene homolog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KRAS Kirsten rat sarcoma viral oncogene homolog
LIPE lipase, hormone-sensitive
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDPK1 3-phosphoinositide dependent protein kinase 1
PFKL phosphofructokinase, liver
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHKB phosphorylase kinase, beta
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKLR pyruvate kinase, liver and RBC
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKX protein kinase, X-linked
PRKY protein kinase, Y-linked, pseudogene
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRF protein tyrosine phosphatase, receptor type, F
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
PYGM phosphorylase, glycogen, muscle
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RHEB Ras homolog enriched in brain
RHOQ ras homolog family member Q
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SORBS1 sorbin and SH3 domain containing 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
TRIP10 thyroid hormone receptor interactor 10
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2